JFIFJPhotoshop 3.08BIM.@26 Years of Advancing EGFR-TKIs in Non-Small Cell Lung Cancer: B720260428PSCIENMAGUAuthorv26 Years of Advancing EGFR-TKIs in Non-Small Cell Lung Cancer: Breakthroughs in Clinical Use and Resistance Mechanisms Science@https://scienmag.com/26-years-of-advancing-egfr-tkis-in-non-smal© 2026 Sciencehttps://scienmag.com/Over the past three decades, the landscape of non-small cell lung cancer (NSCLC) treatment has been profoundly transformed by the advent and continued evolution of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). These targeted therapies have revolutionized clinical outcomes for patients harboring EGFR-sensitive mutations, ushering in an era of precision medicine that has markedly […]ScienceBioBiologyBiology*advancements in tyrosine kinase inhibitors$clinical trials FLAURA2 and MARIPOSA'EGFR-TKIs in non-small cell lung cancer!FDA and NMPA regulatory approvals*first-line treatment for EGFR-mutant NSCLC$osimertinib combination chemotherapy)overcoming drug resistance in lung cancerpersonalized oncology therapies!precision medicine in lung cancer"progression-free survival in NSCLC(resistance mechanisms to EGFR inhibitors#targeted therapy for EGFR mutationsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"@ !1AQ"2aqB3#R4STbr7!1AQ"2aq#3R%4Bbr ?Trhƛ`GZM͢*s u'PKd PE &qLjm|eH"hor9\tsc )06.#* ~A_$0Xp)J^f|F6 ah'_ 9Oz %dW@@=PɪtNޤBT<})A6>!7-kgڋ. 9ꮇ4 .&=83?|ot qb%j:g5$ Y#i˝e0D|5@M!b 4H}dVYfo  h)ڛ4Qv+ ׵dф7q5fiaYԬsR"sPV,jrf,[oH{;-T'? 9\TmiN(%.E/s\OS6K_ӠgS+ M iw]dfEcX9bұ>Dϕ両u̫u==-P<25$b@ucR֬O qn8юCAnI yMmĶW=znЖ",- jdͿ l>P&-O3u~d]"ZL sTAִSsXHdStii8J6pA[` pE2.Xg!%؞UCsplкF=ǝʭ0 5?AZNU ecN= m˕4"ȫ:]ݣ)5 {<%ƛ$qBRޮ-F۶v^k$☴krq[A[\XhyQohGGn|g6>J)yoͧCZ57gP6 ⺕߆rAtK.j_c6T }K حzd6=&o 7EdPlʙs'$T(NJbBۋbH4|L2̤5Ď0<5oD^8Z=%wzU6נehRjcɫ^? Vken|49ye>QtױEgK[H=ѳ'׽;}:Uu9PNm"k4ӸcTp>)|Nt+yI2X=m`zVHuit7vh=E[s5T(85q-`RF G"H0|?T ֖>3$Mň:[o"4H<{͏!c@mF*H"ϻ [Q[HuAҦq&hӼB+<zy%qoG3Q2AIvYUU!SE4ݠ<|%=֌Z'1FjI qe&L%d18i qt#Oi QD ʁk^`ec؁([t,hٞ$w L O<ȇCV/--KlMJ0D:ƾ${\d^ 7æ˧ȒHl #gaac6ہZd=*,9gs+6FkpyhȂMo\imK+ַpby&8/lZ.?j?}q#TLdVZW!մٴ-JImcW*G=ץC$̭qMEZӱ!uFiVxWǜR@/J ockH+OrV(ʖ ]F@YW+[羳f.{#꣟HRXYe9*S~t1,5 i^yR5_ AVK!sW2|H~H+hX}+Z ~ e 3V!WxcH8ke A¤㯙\cE66aE. Z͟ܧxq 'jYˈAhі*dԢ~+5+4Jn 7q!>ti3 P;2GWÞB NTChN)kiF?42Kծn7C2$ڭj[=#)\u#eN:W:1Io199,L)Fd} jI|rb2M!?/΃`reEӧJ$2L[[0fUaTP1W!qe>'?sV>tn۩fu|=b_Wc>ԞBw$l- e~ R(!NB>_Jf>@#:Kp܃:QZ0ɥc#^vZJZhZXtm0NG0Azp`jq~]!`c*߷jnTw='4>[Ժ9LK~u:o"S۟A 8{LGVvt܎}Ԩ^X-C7%ce \' UxFr@Vuxe*I4,3y0 3 L`*$$ 7͏rkmډ0x5Pb[n}+V(mb#d׊SkckbRτdZ< [xt'UzrF_qꭲŒZ9},gH+n(Ȥ2Iνto&2']yu-w!=΅}r{J "x{J`Xޥ&Ԧ_<2 .PNYjpTXn,;)RJ#L% h}$ +82k|RZ?s[T\y3TT`'ӽZNhE)5UiR`L<Ιحe-튻k#[%[P4Qð3zi9\Z&.qYt/"HH;*p]eFh=\vjde{P$`݈%J{TgX ڽTG Lݍ 5*UZ3V{ԩSh=TRO ansUp=*T"j'EGUƥJSjW^tJ֡G ThQ3?*(T~5jJ