JFIFVPhotoshop 3.08BIM:@Innovative Theranostic Strategy Delivers Curative Outcomes in Co720260430PSCIENMAGUAuthorbInnovative Theranostic Strategy Delivers Curative Outcomes in Colorectal Cancer Radioimmunotherapy Science@https://scienmag.com/innovative-theranostic-strategy-delivers-cu© 2026 Sciencehttps://scienmag.com/A groundbreaking advancement in the realm of nuclear medicine and precision oncology has emerged from recent preclinical investigations targeting colorectal cancer, leveraging an innovative pretargeted radioimmunotherapy (PRIT) strategy. This novel approach harnesses the matched ^203Pb/^212Pb theranostic pair to deliver alpha-emitting radionuclide therapy with superior tumor specificity, thus minimizing off-target radiation exposure to healthy tissue. The […]ScienceCanCancerCancer^203Pb/^212Pb theranostic pair$advanced colorectal cancer treatment#alpha-emitting radionuclide therapy$colorectal cancer radioimmunotherapyGPA33 antigen targeting+high linear energy transfer alpha particles1minimizing nephrotoxicity in radionuclide therapynuclear medicine innovations(precision oncology for colorectal cancer%pretargeted radioimmunotherapy (PRIT) theranostic radionuclide therapy$tumor-specific radionuclide deliveryC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"F!1"AQaq23Bb#$4RrтSTt56Ddsu9!1AQ"aq#23Rb$4BCr ?w:ptbq~$Q,6g$*-~#xV~r8?W85a0-HӁer[dj"3D{ZԥξPڙ*+LN3(ITr)MƯEã%-I ү/ܙj;jT$cKVŸŊXja X'Sb.&_}U;WF$4r{ 5=2N2Ά/0W}YO*? 2E !oPzL4fi^db|T@W:78>GcLn*q6L<@U7.e~r{Mxpȯm/- 3+=J(eb8Q*b_JO5v/\ԱJ rajKRj:~I?Y;\4;o{ƴo/J5RJ+>!xҎaJ䜜dנ\/ O iƥUҫ8#m0ZfڴcEGWEl^SRB vETCp Sc*_Vޚ7Aq+QX4ÃΟٞ IO|oBoט/U” ?">t{E${\C:#%*!9WjN/9-FK5/==odw뗗Ky=YҞ޶9oʭۦs%KY6ARnOHpQHߴ?ǓÅS Hv=* &}-m3A iC!BumRZP o~CH1&o0hׇTRG[,6q'EWWa46rCΚ.UlI? *qu c:0OTԶ'bU={Mm;l2 bJ)\h=;Uj YwFLPY !17Nۈx:#q+9;(Jo%gVy0qDHEҐnr.+c!og x%)ع[l^8Wfk$܇JaB $n@4lxO!QpBTylId#mN%1N6쌰t%\A@\cYt`?}|lՍd[^<Ι%hd<3C5ن7;֫vq[IGkDˌ祠8S#pN6ޗF޲ r's[9y  63dc2Rd{_//jsoԪma[Y ڵ̈ENf@;/~i>!}/4j1Lx?Jv@6~L'D9&.1e,s[g`pQqvP7<7JD<Ɔ[c#ZD=yGzu@Ct,GMoHaj,siv7*)^fRT+I@#0L6]WmS=Gq{xfRzNkv{kl.v{qB^i|Vpw2K|ƜH(XjpFjp?># w9mz$_8Z$`s|pqYl3*4EFJ$0w#Bo̱"اqq 첡¢;>tVHwZZNQIH+yPNY'_k7ԇ :KpG˰ y7fn\TT8J=҃rqJuYR@++2X~:06V21ʾlen+ evZ<^p2]jB0U@GAB9I].6RGX}MBe%'C#_ƞ(cGС_v0妃B Z]xi%O.#̶/ i’ѽpÝT…J^ҤfC'!8՗ vqa 1Ro9yɯv?z{g=+dsD潑ݏg*߇ZmMtq?ZrwYV+Jr:ԹZJH_|4 {y!JHJRqP5U0 %۟Dq8웢QlO휧cL6G\aY R)geBYg:IV V"DeKFeqH#HfK;۩Cg lM{[Eu\{b3 e/LXqҢZA6S#!\08úQ-B՗JTI ܛEkY$yPDWHfctRؼg  QVG6<;kJmmj?TvQN\huհ8I9m6C?%L!]"`u`t[DwWI){ǽߧzۜrKN8_oJ Vm!?vbn)ґ{rvڱ]'=~ޏw%qǮZBpaa=>4\FX#î]|Zܚ|qHЛ];PVY+%Ne,3`ffqxRb\HƬ5Rqm+xS3dqmpBTH(Eb~e2Mg?P _ri HjPZogȤCD6qd:%YaAE;}jxa1wq99ڹ71%Hy po6΄RB[Σ (AI۰lDY:Ƙ 9cI'*yE' & [:ZuHm+`7Hȹ ܦ!\+TH |w). -^[p~ b+ָdIq9ԭkI2AUp*Q(N*A/T;m@CPBG$G40POacNȨkCd ڥRqLmQp:UQ)g bsM$chK`r,Ҋ B4y->5t]%nДF ͞Er9)$ f\2}f-v;G%+_cN9㉼wҵmIL6PQ}2ʹEY>9}+_?v{l@R%XZM) c]RS7`PLjCSb^6:Gx3?5R!PBs\/=3j7|34gL\'<2pUOR_5 T8L{nsmO@mW&eRJlCʪaC<] 8s5Wk+W=JJY)'R!mYevB՚qgڗ M=)HTNqRD 99A ſ Rx@2ɥAR_!6†ǀwЬIl-l&4X*/nkhqz{  !PRͫ/)` ק^ Ԫ} pʶ4 r䕲;ÊD5C:1OFXiO2$ikCQxsCxN9DCkfXAw(E u᥅lG{tc2|hÛΥPr69۲iGj[_(g5J[YrrdHxO%~t B~/@JbHPW-/|A*Kq UuA~뢗1&v!JZZGJ8:5 JtMΙ mzߥ(n ;I s.%;4._o<̒ju'wt8/='z/w OqT@ eB CdN(t9ɪ"+90hKZTF!^+5tFzW2GU;ܚՠ;$,?:e%<6)#4D+B =捧B2V>x?B4 vNRU#;\09׍5mmXR~L:ҊԩF1T.=1}*PR F9kgE RݫѺ3(vtZ?GTEKC;^'H_fJCr|gTUjR++>Ҽs*]BGQH?T*T+ U Y`DU Lv%TTR k+