JFIFPhotoshop 3.08BIM@Scientists Harness Large DNA Fragment Assembly to Engineer Micro720260506PSCIENMAGUAuthorkScientists Harness Large DNA Fragment Assembly to Engineer Microbes for Producing Diverse Complex Compounds Science@https://scienmag.com/scientists-harness-large-dna-fragment-assem© 2026 Sciencehttps://scienmag.com/Recent breakthroughs in synthetic biology have revolutionized the capacity to engineer microorganisms, transforming them into highly efficient biofactories. A comprehensive review published in Quantitative Biology showcases how scientists have achieved unprecedented mastery in assembling exceptionally large DNA fragments, an advance that is dramatically reshaping the landscape of microbial engineering. This technological leap permits not only […]ScienceBioBiologyBiology(advances in microbial genome engineering/biofactory engineering using yeast and bacteria*combinatorial genetic element optimization0efficient bioproduct synthesis in microorganisms/genome redesign with high-fidelity DNA assembly5metabolic pathway reconstruction in synthetic biology5microbial engineering for complex compound production6modular synthetic constructs for metabolic engineering5scalable DNA assembly techniques in synthetic biology>synthetic biology applications in pharmaceuticals and biofuels-synthetic biology large DNA fragment assembly*synthetic chromosome synthesis in microbesC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"6!1A"Qa2q#BR3$Cb3!1AQ"q#23a4R$B ?.My[mFxrQn\G5j,[GsyPn ZvJZkMjnky$\?5#$fb^![eKjxr) POE^! {"c FB2)*AjrX (m2I$"-)ck# {usT >JXѻn) R2{v `%va ~yYB0k+` Pč)qiD⣰HÂ[-+bOC[$idEu+.= eajJPW6. ,ÓZBKmjj }dGrœJ}?XlnRP 5ʄߣ 9h[PZIOo ƙiH"]<(_@$sލtfaH v*#w8X(aol`(`GT:؎qU&\c)Rػf!J@J$6);cZ=5*[AyJS]HU%MVcō)V uR}t[iS8ptcT{|3=*[퉝bվee%KW @GzjC7%4~RA)Q씓JF 'mi%"pa™9V#+SGq@z=k++jI9%TUEkgܚX%j!C<#~:ҹ !$`OnnCۀ;˶m0; -{T6/z&BKT4:Pr YùzTr>iKC ގG4& \Zj#*v2O M $(hlnv<+tT.)ϵYzA`7yK^pBZ 6ڼ9_kҚP"ec#ם/{չYbMFs9dY̭TBX$I*+E]ُJy!d%ǐiK.<\@?Z LS3ֲ:hZ@ 簫\VAV7CFSzt'M%X›^NG 758Ca<P SKmai\gΒ#" 27)bSYGV *[qҕQҵ/j{S4ösK]bgqՕչ]k(16gԪ;zJJ3gOC4P7[5;9~z=]u )Y?@6EkЦ=3{pjX"j<> 0prF8sO-NiJJՑdgnw楱p.g{)}E*Pڂ/9(%: QSh_J1W5wbU-UWJ/hT}MnJ[PPE5t-]N$p 27o wznm!6nCm O@=Umߐ}ūco|ٱ뀭B;r~jf% +/ >pe,?U9E^1otIׁ~kAD'Mϼ75$p=Ncw ?P(09&R|pQ=?^98!;,A@*n춯yD7pp:(v[$G~-ݚp 'oԩ;sRi q5_|vM[Ұc˚8?untM7ode) vnh_d9^20R~qW\K yUNs(U)9/$c9?O-GtmƸ?{4̚쥩KQÃ*%avKpIR w[{?Kjc m$'"~sFjkcvMl8hdV3:)X]e: =i89^JZZd{ABPz[LmEdJ 4%U3%[z{dWGD)~A190M8V#M\єF6ƓQmߔOK apۯsWK =zT *A` j3i pJmvǸSޕG`AkIO$[^""dN}B \O83EBYCBݎuTU)# >59#CIqk44\5PNA $f<9 D\=%~ 998$d=A W=T`.#P,ÇjiGwr,C B?'M֢M< GIJa+ăz"/))皖ׁ8Ec8 %,v{R@ `|ׅ99)"d]թ F$ #p Mgw `YZ5n8K]H[|5UcҮas)W!p5~} u' -KWbmTA^c)uHX4p6/5 zkS%h'_CaEcc#_ґURXDK:iڪhf0Hg4viIra押.= Z[Cᦤ:xh=MEcl@!m:/POz޶aUO(5j^aI=nԎ",ͤ=^ -PKM7,jΓ{-gCIآ14'+Rt3lnR>+#`X P]J1R@tM\j(-*3*:lJR8+ՂRڕ҇aw GgC 1/X];{U<,"/qQʒ:TuQm'y8YWepW_Zy֖PRT:)ᕫ ҩnuj4"3 C Rq;~2,JiH-pyI~mTF5dkmH4M9)ͨ6o5|W"tv3uT9f ?k'DOj雖E\nsg(JQNM2i)m*Tthw)Za'(6K)H[.%@+`ZTg es2Y|o-kЗiVp=Vj5NKAk,s;-T/2M\ĘT~Z!&y#h27LX&y!)u$َ )5c2[%| Fr*A .]rT71F!^`*%BTw$P ߇= 4vB}I>2…Wh,(nj[D~_j ٯnI( 8W]mS:Jd)Cjɬ:k*iEH%$w\8QjYsY8Z]mѮ:vl;WU4M4Y v0plfC,$m:V@MK4+ٗ4Q#k5|Vyc^$}`}ԩRGRSh,r=j%HRڑGd͠a)ԩP6 靊csJQֿ !tt4SҲT*T aTq6Jt*UZ