JFIFPhotoshop 3.08BIM@From Immunosuppression to Immune Harmony: Advancing Regulatory T720260508PSCIENMAGUAuthorfFrom Immunosuppression to Immune Harmony: Advancing Regulatory T Cell Therapy in Organ Transplantation Science@https://scienmag.com/from-immunosuppression-to-immune-harmony-ad© 2026 Sciencehttps://scienmag.com/Organ transplantation has long been the definitive treatment for patients suffering from end-stage organ failure, yet the journey post-transplant has been fraught with challenges. Traditional immunosuppressive therapies, while effective in curtailing acute rejection episodes, fall short in preventing chronic rejection and often impose a heavy toll in the form of opportunistic infections, malignancies, and debilitating […]ScienceTecTechnology and EngineeringTechnology and Engineering'CTLA-4 function in transplant tolerance#enhancing graft survival with Tregs%immune homeostasis in transplantation+immune tolerance induction after transplant2innovative therapies for transplant immune harmony-mechanisms of Treg-mediated immune regulation9modulation of antigen-presenting cells in graft tolerance"overcoming chronic organ rejection'reducing immunosuppression side effects2regulatory T cell therapy in organ transplantation*targeting effector T cells post-transplant#Tregs role in transplant immunologyC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$";!1AQa"q2#B3Rb$C0!1A"Qaq2#$ ?SJR%)J(BR JiN2µ]\IxmI/h;IPi"amҔ$)J(BR JR%)J(BV9/xkڑ~le/8J+~m=5 ')?ڌ ii'ޠ&ܶj.:Q-ÅzEjk,+,'Td v-qoah* uBJ+wQ?֡FCp s49i<>mbMeHRF;[#q=kh"ܮWyIsj 8}2A?z;t.)L)[0yǰTmfl |n֑Ht5֖²s5c+]=3&.Y3G5]C9m9F94FA{C QV21ttD3yBs[OJ)}2?(׍K,s cV_-0M;|ʲӴ0 쵵D^#-WG@ E?HTL-L̴lˆ Z>PArA^uti&?U)c ,g8ǚvۻjS9p%iQ@TP[?NmDE`wb)1CV'u\rx#bVt ֤86-`;x")EBB ~GI (`6'kq*aҩ TZ &$4:N+ftgvn%e)_8ɦ9Qio`\p`ݤcr}r9܃`.Ci#)W8n9 awoZctSYʀ'e*h:|C+ӣMTdzJr:ȩ߮mi nj[-́dղ?WXѸ_4cho^JԺi\\>>k%)JZR ^t2Wd$1WX!.5B'=zm;h?'%+CjNsfD8!$`W!qY9Ԅsg<3ۏJu ]dpY {/Ko̚z$)sϨ>zI oj;㲢RFq#W(]aKq7: 銺tḅڪݎ~C؂p}ZM:i=,u~pN q`j j I>z_0lk4Y,ʉqNխI ljARV mP{]aXKYHYp2TkHm$(9f9+AOem,,uYJDu% S |%'kBl`m Dr63ZѼ^bYPӒ֬y|kIW;,C=<-}nG'We/jy|ǫT<76{JVpxe)P$ ]VM mTz&He)nuC{C(>}Zz~\JHma璬v>wËB8ǵv[l '1Yy짵'!k|7(MĐ1@V>^)JRs#%RPO*ҳT IFݢOGʖRIiK Mau65zBLYR (W?UDme-$c_D>F8_lą$Ăkj˫ź)xKRrR33]|FlU@x"-]W, A I1}RUx_m%=V>U`˃ 3_].m 5Wnc–h䴬7fǏ;T$vFj#R^~yk#?zu`ҏOqJָ[*B7aC==YAvǞ|ռT'9GsƢyi|F'LzԗrFel>}qQ gY5Gt-F; Te꛳,UDa^GI@X f*Kccn%h^R#GX%)$%!+#۷zD,%MEr' DS Rʷm? h[q][iJO^m8+YIhWQRF܎جi(+] \-@ml~xNKJx*I5tt6A'R+y`E\ mq6]qKe6-'8*Ǯ-t\Y:\:H1^_eF^V `|i(]9SR'' R n?;w16$<ʕ+=W65x!P8SRTLaRcs˜,;,֖JRM%)^\q H>*jdHyRL2ۥ'%$S4h QQH˪W '?޺K)Nngr`r~)[PqNRA#wG#\=GDsk`|-qkrKqbj?jX HJ Gb;{v")ĭgiNp'wSr7ʠ?֦?9w'MQs&{cq9'$ R";[NGnm)xcuK-![3j.-Npw=|rKsM񴏿K,-~ i{5C .+/6Ug˵֗K,x<Ү$y?e(a/-O,Hw5d\EF0qڵO I<_ѵ`,^fȦMH9IO>~# 4KCUT0ċTUOR{ rx9NX\\t!+%$#>cw)lt[dakݦ8  PI޺>aHu !99ܷ\!$Fx+ژjԙNBC'v柮fr;3!eCo )X)'گyaÃRlک㛝Ŗ@{ya\>*ev;I)HojOl`dsʿZܛ\iZVc&fB@?n بmppMR.yqڛPT?JJ4ޒ-QKpq}-a{] g[D.+m!scg5Ъ!zgc .v8=Ts!~ `ǧ'"6 R.,~8omh!L#+Od!+F?T;- K,$1kt8JkdN'kmNmJh 26⪎Z $B\En_tűl$O#gޕRKc'wo{+!R5SIlaӴnS!>TËyԤlz֖M\eOg%?sڭoerJėz.6>c5tږ3WVPxm_%=Cse ')5nJ- )${ 1{{vzi9V7U$:AIm\kN1ΘQPJܶ\LV0r { oGnn[ҹ#Qw Fx7qSLCՀ)x[>jC0s-{ŭhƲnTc=nRI7*Z6)\JJR!+CXĐƷIs MqoTuTMvK،%)$dq[a=[`DgBv# iv2rd-cSOmBV C}}>Bf!MIhnRʽB,Я.s=dD?k4F1lnRy$ZkLS^+[OHo. SAwX `''G× ,4'cYI {5 cyH= .«5CKVn!ĨHt[.l$vʎ3V2'EM5tE"}k%5!KIN%C,q/TOAY(>ǁO޺\ʟՑV HVq߹5)tz2H\8Q%UN6v9RTjs9Բ kGYr`Z# 8gի##NJ+b @';}Mk: GY)Z&xѹao#{gJd0H)@%)JRJR JR%)JLHӐOk-(\ ) HHUGAR* 8H~U. eeԜSR mĸ=h/F—@[c9*kb&ź@|ȌT5QjJWLow -i+_h-QoݺC+sR>c3?ں .3`(dc^R댶R zO]a#[{rn 3֘m8rYJn8p(]JR!)JP)BJR!)JP)BJR!)JP)B_