JFIFPhotoshop 3.08BIM@Nanoparticles Combat Drug-Resistant Cancer Through Sequential Dr720260508PSCIENMAGUAuthordNanoparticles Combat Drug-Resistant Cancer Through Sequential Drug Delivery and Photothermal Therapy Science@https://scienmag.com/nanoparticles-combat-drug-resistant-cancer-© 2026 Sciencehttps://scienmag.com/In the relentless battle against cancer, one of the most daunting challenges has been the phenomenon of multidrug resistance (MDR), where cancer cells develop the ability to actively expel chemotherapeutic agents before these drugs can inflict their intended damage. This defense mechanism, primarily driven by the overexpression of P-glycoprotein (P-gp) pumps on the cancer cell […]ScienceCanCancerCancer%advanced cancer drug delivery methods&amino acid-based drug delivery systems'combination therapy using nanoparticles'multifunctional nanomedicine for cancer'nanoparticles for drug-resistant cancernanotechnology in oncology)overcoming multidrug resistance in cancer)P-glycoprotein inhibitors in chemotherapyphotothermal therapy for cancerreducing chemotherapy toxicity&sequential drug delivery nanoparticles$targeted cancer treatment strategiesC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"6!1A"Qaq2B#34Rr1!1A"2Qq3a4 ?λU"qQWU=Lߑ-0sdF3KinI>jmz! *\X$֥VG95D{T QzhӠ2rhfCs LXyi^l vJsa ȡN-JȢx:k 8cKy@2)=v9hU󲏷Tl^>B\rhyh3-htysDX0Γ+vd7?EC%18{\_.c[[1"a $w5z&F԰yIshpx|:Hۼ kCD6-I5U-u}IkW$4&DQIfɜzQHz6S :u͹kڗ?ZN @^q5d61L&mAsE-6,->V%r\GQD v lwq aG F(I2m^iǎ쬹\TMgrLڦ+[ z\(dPy1HoM1Vɽ"Ӓȣ=Y*[ SȥM:7I*6| + ijJXbJߜgmJ <6JR;Ԧ{WG7'f]mSIFj>IHCw.DRRH]e I敬ҋ -(HZGÂL!=-E-ۊ\vZԯ$P+MY"ҌZ'T}Q٭oy'`j+T.B<&y=tt)/ eĵst(_e+V)2I·UV{M1oPj +Ny wպRrK\l6H&C+g8I{ 6nCK$LH#Ph{[jAдC2M@RWCc''xz;% La;JOiSj}iH#84`NFiTT<o|Q/wB#TȥyAa:^vG€4J_1dCajZ؆2Aզ(!ga$³m{Ҋ}8̏вS 82hj㬡J@_.Ir㠮I;v2=ViTp#[^)Wl+@ >86 Ȅ3nMF+@#%0R,%q[M[&\/oN,Y¶V)^Uhae4KupjY䎜PNj Vlu?%ӄxIl_I,~P1.:Br *Ѥt\~ٯ Ϲ[CҞWEDL̇OG4Lk$O~daFoMP3ؓKoOq6$?5S~$H??(tm))aŭ o1YKul}L9KZ;= ƔP字>ِVO*#Q 6qA5ym[R\PCho+XPk]pG+st !A~"j{e,uBRT1π+]- I"S#;B7` W&xtH53;aq=ԧjZnڙ%)*^(;MJ"<+0#Hgvnh$g9JumadcI:AS4'|rmN!?4䜎 ynQ- gO,{B+7ԫ-#Tɐw*3}MRŸ흊Rs\p(pBc8QW'ĻĆtO;>iRvS{1^D.̙:M-g*H>vTD43#!h M:ДR)P :M-[bXrʖV}DlP W }+C Q=:c䄔02N3B(m%dғƹ򨌾HFp J8ۊpϒ۷S=}T6wFڒQA; rK ']pL ::}C(q,r0p;Ƒq[jK*W IyC}Ie.e]@x83r\8UԎAe[s2qB?p951nkۊUd0n͂ItiO[Q%/ 9IǞjA5W2d%,6;2Ea!%㙭q)O5x %stfLTDkɻLnFˏ8pcm9m qMPƐQOhp,wcZؖ.SVT2|ƺvh0% ɬZ67ߛ,% pAP\[QD6ɡ4[^XҵI÷\ K8;a.FEbdɎD'qʰ+kN^ߨZTԅ0ZRlQJ3 HxN鵰.km)#*X95UkZȓsSIqKQ;r1ڛ+q Cjs҂R{e&}lY[鶴Gc-m qDq;,Bysu鎩+r|#m!C@7`ָ]_)fZA:5jprkQ5p+r2lp5$mAJ5/+,nIcGJ&OzE u@B!RY J@k.f2ۍ((O>jcK/,i uUu[e%GR!KiI%a c"V89;qmpOƍ04FÓ)=U%.9?JZNĨǐ9V\qe`ژugiDT7 y>yPx"e1礏Q)!qZ|,Prtѹħq@kQovvh4V+J {иɐ$9 [nXB\77+l.CmK$rQP?(ޓ/vR\%2"65-rYqKl}9)BZo)H'b@]|نbau ?d%kU@Zn.U|Uo]MVAd>՗(IcNizņs.n)Rk;sP H-[uaX ӥe"8a0BW]f3I$&=P,AKW?aG^(E`bi dbGSW:9r='Zyڋ>S'ޥϚ / ZZ*T