JFIFjPhotoshop 3.08BIMNBSNU Professor Sangwoo Seo’s Team Develops Next-Generation CRISPR720260508PSCIENMAGUAuthorSNU Professor Sangwoo Seo’s Team Develops Next-Generation CRISPR Biocontainment Technology to Control Microbial Survival Without DNA Cleavage Science@https://scienmag.com/snu-professor-sangwoo-seos-team-develops-ne© 2026 Sciencehttps://scienmag.com/In a groundbreaking advancement at the intersection of genome engineering and biocontainment, researchers at Seoul National University have developed a pioneering technology enabling irreversible and precise control over engineered bacterial survival. Published in the prestigious journal Nucleic Acids Research, this study unveils a multiplexed CRISPR base editing system that activates in pulses and permanently disables […]ScienceBioBiologyBiology#biocontainment without DNA cleavage#biopharmaceutical microbial control&CRISPR base editing for biocontainmentdCas9 base editing technologyengineered microbial biosafety)environmental safety in synthetic biology/genetically modified microorganisms containment#genome engineering in biotechnology"industrial biotechnology biosafety'irreversible bacterial survival control#microbial biocontainment innovation#multiplexed CRISPR pulse activationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"D !1"AQ2aq#BR3TDbS$456Crs)!1"23AQaq ?bL'ǚWk-L)MXIR->ɯ]$G^P<5qii꺥\ٶ~t=+z{$9Oԁ4sC;%A_PerO4Nٮ͆P/:4hʖvZ)peU <)a?TkiD-*IMWl(r M?gfjgUUn>cFfJz6V#6 ؄{%8|7#MV8~V+#g(fZJTp'Z-eT7ҥ6xR~"!Ez*]qI~50٘> ^B}iQhEX M94ݷQi%MVaxCn 򽀤`O|mwj.$kڪ5E?LamNRO\w;F&;EWv?@3ZFܖ[#hɧS:O$ĒBǵC0j[e@85djˬvx"c$BV^DU>$%~]SЦ[SX˂qxjB2yG7xMbBh=U~dSzJֶYs %&>%G*4U lAkVqskY]|g9Y/qxzRl"zMf+cmRS$cݏOJٟyָҕo$ 'T(.HFT0"< @ QK )mL3Y46ٖrӽ]sEjz_R P ljyIX^Z\a^SdV__a:ӥ/y3U]jD0tv yS#+N$^'XP_9⊹PkzR;iPFZrF :щ-' Qp5!Ѕji V*QIjM&+0kө`5J ґcJSkpڤAo&?ßxi8.9QbqwoⰴtKe(FPcOkDWkVd-y2|бWrz13̩J08'hrCB2r|ήݦ:\JO-ʑ5/쯐PHQQ@bٽN'?m@x0:#/LGq{Kp1f^Zsaj%WO|ON\0"3jI'V?)y Qgˤ3~z*3SY%<<T,䭃0\-n%=?Q#9DBQ'TMGg1//cIfZ>l1 c78^šqM?sIgT^G?TœSTHkQ=i*z8fy\8a] 52ךt?o& ,$yFiv2|o}خ H*(+F91^Imwx'Q/,v:[ fꥈ'cOeM})<`:doliIaJ8RTC#ySfpp&q\\SepU\҂jNl bf¦~GӨ$)%侠q_}CGft͕"SҖ;/XdIqn5%Y*uDx&e]05meQ.VD/UC*v4BfIU Mmaќ02 ]P ~Qym)vmӏ(Un&:jfr,+U4`W.#JU0Sך7RR81)9ħjT2x"+IK VEvˋpUe˪n6-s'0#hD t}3 %n+X[d l҉Ge)Gt;vi::Q{K|mi;Y ;4-ZGʹ*`c4>f8z QAYA VXv^HAIK5+ .Z;<74+ԛsI~}rRۙST4x8nc@'*CQ?+Yʙ\gr}M̗R'4i<YCŬQ4Sd!Rx.7uX[Bs qb":0ްrAa1#,qY[V[IC}ϴyJVI-r/C!-N'~m k!n=<GWMKmfJCKP =j~+.OSCv0kt#sx6Tj;O<սfc'Uh赏Id=Sqѿb2W=I߭*>Jo 4=ŲpҒqj}N9"c48UQQot7?@ JǸ6"n: CLCZЂp Uh8Wz*d`'#U$Q쁩[3tK@Tm͆l-XRkK OEKS ZvG96]YEl_Z]OSXBp k\ 9l/>ޯ(lO=\l;UμŊ3!Cg݁Ǿnۣո=|5 )>MBCkhD?ҝ6eFd(xQ@X4vhycZXzfXf(Ll|}I4uzϞ֢ķGqft Dy⮡NMʕ`o= 9q~BVV~fxƝVT68W=ڭkZV+pjRhP*`9*c2nاpВjEs.$ћ4KCa.+=QG-W@bT[lf5X ݚwPHm.>$f'RDUGfZzβv6Or Dep Z8" ugBXuWf{)!\7ff*Y ZQ xMvۭix>BKqRDp|ۇ)3Ubde 6Q 5oP80I8չ QaO~To؄(psך2\Ʌ 7prgHyfO,X>,% ~cD!ۆx&BT g( ̷ocV=ȏ9JH P'=h%X>ʺFK@dK@Wæj[PAȣ.Y[ ҫ}ݔTQΕ/!ʗsASrTjuDDfQm4viR2cڒz цu~5W6J)j6>4f+)%>t =<% JP>=vjvBu<e/ ApC O=)ZeW1.f;>6PU<]G[1`)-9#֭aI=+Uk䌗$)!eG*Y~fʎ+hTp/+mA˵,D*P[O_qUnf%3%DӃ26jNqN%Op3ZhYڒbp3iNݠVKE^q$jtou|Y@$WVV ok۽q2"#S!5B j:*yk0=5a 1ڋݭ.H [}k]ECXN o(Cl#2[%㧭BV+mq:]u^-wƀPYWܼmT[b8۫(Y?U8(gCb!.Ӏ*6\iOne{MG)Iȣ;9=ț#x'X9BJI|^ܲg 2Y$TEo ~Q/zl℮Z-RH>}3m eg֙Ko$7pV^UH#9ޭN9  H#V3YiAd$' bCR˩ʇ'O87+:4j4rӨ}4Ml̹BK`\'\Sv;iSMɓsx3Sfu{{'/e!g\uT0\*DYʔin!윩j*!-iv}~'e:zClLv Jǭ6uc]n*jJ1?MsKԍ>5