JFIFPhotoshop 3.08BIM@Cytokine-Enhanced CAR-T Cell Therapy Shows Promise Against Aggre720260520PSCIENMAGUAuthorjCytokine-Enhanced CAR-T Cell Therapy Shows Promise Against Aggressive Brain Tumors in Preclinical Research Science@https://scienmag.com/cytokine-enhanced-car-t-cell-therapy-shows-© 2026 Sciencehttps://scienmag.com/In a groundbreaking advancement at the nexus of immunotherapy and neuro-oncology, researchers from the UCLA Health Jonsson Comprehensive Cancer Center have engineered a novel CAR-T cell therapy designed to overcome the formidable challenges posed by glioblastoma, one of the most aggressive and lethal brain cancers known to medicine. This innovative approach harnesses the power of […]ScienceCanCancerCancer#CAR T-cell therapy for glioblastomacytokine-armored CAR-T cellsdecoy-resistant interleukin-18)enhancing immune response in brain tumors'glioblastoma immunotherapy advancements)immunotherapy for aggressive brain cancer interleukin-12 in cancer therapy%neuro-oncology CAR-T cell innovationsovercoming tumor immune evasion+preclinical glioblastoma treatment research-targeting tumor heterogeneity in glioblastoma!tumor microenvironment modulationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$":!1AQa"#2BqR3$5CS6!1A"Qaq23B#$Rb ?W(J.BBWP$6kPhBEԨB9xh N.42JS^y[a c_$h/|Ot\MR,~E!BB>:Ld.Faso54e⁤lr'bmK晑H=K^h ~H$ )HBq֛VFIOC5JcdZA$^+|8)Kr 6?V!p۝>tEL{ಛ27~ =F W,Zl1 yd2Jwv.}F#daps}=S0eqլHui ~V\3ο+\`{'~cy~a5ʤGvL+\&'V kn J,I.99(]t?=뮇CYg´_Av!O5W At iu5=|}N$噴P(Bx,Ǜܭ# LO]K;pX-A!BHVJ >ywD3 ުv_)dE"Tʴ2y{X5Pg7e׺K+$чvI:T602ApWgC^3Kr!DX CtsI`kR٭-nvr{F{@g*[̚Z`.6z?u/WXPA-to_=ӌdm>%h \ | YI mn:Xu:)ύJyFFcƎFI^˜ri‚|EGUŒ ơy> o|8Ś6"hI-wfpJIƇ!LoxG/DV)6 %D{/5b5|}l%KnFCb{6L(, bxіi+Î[!E`Qehk/އ8OïV{!r(ii)tgȑ Lvd;ַL.*wxVtoST6ji:S!zLbl>;/0߽7oXtl#ȓ`F`-f|+CeeZxSJH=7S.QGD>{2a#+\9BlDHiW>/~-p 8 _ž ǺAoh0dspOkdՅvDmMK$&PpJi O(cnA.sZ6+:Fw]~[{+/#.WJ{@v;Rm9N^J;7]aƾg:FQYBט89y/C5B9Zy^Gv G=kA&3SOE8gku1곬Gй5Wݭ"L5j%m:_鰫\ym;K ?؅xtsL@wbmk H;}mV,ʄ&к%kNH(iD֤q[-%_d~f`~Y__8Y˹Yɾń赌#v8yk۲ᅥWKv?+ xv$Yi?E n{mA=wFz1!#;Y}exɻlQ_~*fPdOd;LR{2xk #AO$}=o_V kI n|tdžf!Zǜhgׯaչ{+5\d?.&s9UG'; g=Z~3Qк$nP[>g8j'ZNZKO4A~c.hֈ)OӅǿ裱88q  D;hMo~e;'\9[\<)]/lPD v~q?miYs$pD O.hoFC,v@J9.lV/2 ycaBʾM:^rP$B u^)O FRqS3%a}˯oBh. NQ%u<|׳;Y>cfdYrui#EYm{f}[zRvTcZZ|ZW0n>n _*&Jc㜎Ԃʿ ع 1=5È7:ɇ)[^4 .c5' qahT:9lsM;.yUCd&76{V3M'8 ur+BWi\B1/^+:*o`njcp\kP<šQXtW@c<;g±+j_ zk XkY4$_FCLC wAb< wx*橞o =%&/9^k[q|4D29 [sx+|N7>Tt{n&,@Z>Gصyo<3Ô I1I/O4?ImY[4cqC>}<3gFs)w#޴O>=l|KJɧ>o)s@zի)ZkZ>!$m˂nOcbkT+OXz/V,׸=+]%t&dgidmN${궘7!$W$ɘEXCܿv2WEPHITbKUd{}JM*9|m6T. VV9KEzGfXIg0A(Z>:< 9B?OB_J`Gxnt^EO_c]U}b{8TT!KB! ]4tHM.V~L-љά;dzUB$jx?)^;nwR#| |8Vcq!׷b;RqlY\2xce'uwWΎ "{zaG^w[yműˈdOkZk9?_86MFƟ#z׎u7k ~H94GpUM$̫bF!F1.ѴE.Б%S<+·IwPe?ș<‹f%2㋸+![߱Uo#9%PI3rE?.! ZB!B'8܅UlWI:-p;kCjo5haubА݁GKdxJi80xq~1eV?5CP^٢Ůf{8vY$'/c7G_᳙";"P Jb'r-g<787̫67ҋBb+:7} ;P!%B!B!B!B!<Ò2:!H{=G7/&̾8`w(BO*n/3WB%B/