JFIF4Photoshop 3.08BIM?Breakthroughs in Glutamine Metabolism Uncover New Strategies to720260526PSCIENMAGUAuthoraBreakthroughs in Glutamine Metabolism Uncover New Strategies to Target the Tumor Microenvironment Science@https://scienmag.com/breakthroughs-in-glutamine-metabolism-uncov© 2026 Sciencehttps://scienmag.com/A groundbreaking review article published in the prestigious journal Genes & Diseases shines a spotlight on the pivotal role of glutamine metabolism within the tumor microenvironment. This comprehensive analysis delves into how glutamine, a fundamental amino acid, orchestrates the complex metabolic dialogue between cancer cells and their surrounding stromal components, illuminating new dimensions in cancer […]ScienceCanCancerCancer%cancer metabolism and immune response!glutamine and TCA cycle in tumorsglutamine metabolism in cancer glutamine role in tumor survival%glutamine-dependent tumor progressionimmune modulation by glutamine%metabolic flexibility in cancer cells-metabolic symbiosis in tumor microenvironment!stromal cell metabolism in cancer&targeting metabolic pathways in tumors*therapeutic strategies targeting glutamine-tumor microenvironment metabolic interactionsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"=!1AQ"aq2#BR$b3Cr8!1A"Qaq2RB#34Sbd ?KL2p8p;VK /)C+kr+ $%'o̱SX8"Fʦ69- DGP<;GI{Ql *:W!itGs+yG,NJE; {>kәmB5*'eV$0JP9ӛL m"K ʕPM1cdt6ۑ)]Qⵇ {}I)th|Fw%`erJ>nWKQFgHja$U 8AohPKK}fJֵ\4XPtavR(Rtty8LI "sruD0ZVq%B*:o\Uڒw=[Us.&+*nS#*W HO`)47~x8![ 4ScC'۰s,HǗJ{G׹k niV-3xGNɋm;CQ%MLZ}X7I["3RKl(wu}yn(\U*P .d`iDDDtcAWiwKqG9t"6 ZfAb 9d}.VF1`(:>ԂMžoW˄Gc\Bn3-@0Q'&`{:?n;E/SueZu(Z>jYڞ }2Y˅T䤎֗@Txoy붌s3B(K7Ղr'=Gh$e3dp-*s<ϑ6 97/Onpƌtk4D嶢 ٵMsI>hj-R`4)vd-[79V鬠ӫZC|wS w#QT5eXZZIݴ=*{e=)[NHZH :mWNCH-Z~lA=P6>? qzmtI \w7`/a$iۥ\!rS}ǟR!q_C8REvmSi؄'=৞{h(V;lAt(%1ߩzoIb_yĖQ$攰Oqʒ<MxNI T{УFvvU0aJVdyM? Xn\uGN8&%.Üv6Y>kkI H$;8P-i;o0^i(.4)!kǎ-MCx&FjGw4ކ #C},45+!; @VǓ Z,۔4-=e0Sy?oj=v'[])M!D@慮Gcu`@V~PrAESR,rhٮ>Vw5lNbA=yM`do[5kv$:#=@4iqU9Y->:[βҴ,L'B~?޸e[ߖ>g%lGѩ6 >TG p?Fm+r^eĴO ps/VO˼j.#$ݒ,!EA@?ZcW4.NBYkvʝp!aGuEd!!օQR8#q<{2Y"OYqTO1g٭U)I3M:t ;cK$f{PU9JpAGڲ%(0r VԳk ,@m2`DuBU]r=5cG<uNˮ]R@OU(/4s9JoBt+|bWb*$H<`+DZW kV#EMkBp|(w~Lerq[ִqw+%>6Nc.__+xWJ@k?E2֬ЮY#Gĩ+hP>dkK,'wofC!"#)mH ҕ_^]]il0UT] yƹKϺWA<Ս1r7;~^nK,9vCSНWrJ]ql`K+'އ֍z">NV/[-]^V08)*Ē֕.QIF$h67l醅B\.NRgT]'*W.z?ZrV/>bqZlxW+\ + 9KZ6zwRM4dy*uڂop/Kyӳ?>N}UNeXn.V>mj$к:%@e  +ZKr (:ERٻޓ.L;d3P6VV\q1'_ZA|BܐU{Oݶl1$:eN[m-`Zs:02//WX#jX\-܇nvb{RTA1ϔ,:uP 8TS{n|9n9#Ddo5c79u%f$>x6+cS@+ݛN1Rvж~VUG51Lia* r懨/aJ 19F\ĭA-Jx>D(HBPVlpgvAXmRHY DVϪ-Qǟoq[BccTȋy 8K[Ħ}>I˯aٴ큏%6zqRpr# 8Oq9Tnueb[JRe%$gvϧWl2sL#yRx->øo" Knmrêm#^i*Ҝ0O* ̈́5zg(oPNAMb PdgU+谣QJO{ʄ=.hyg!5p6)WꌩFTgH0ل9M $,$< G4ƞB̦$7Av(=MDYK (v՟olݚt~ŷ[d,)P(Gb(Z*iN_Dq69Dqxݓw K!ZPv$X2kipnӖPڲGޗAK5؄iN?K}hJ\X-2'ڥ`gisk}&&a=[oӑuLJR:cH,TڷH0O![RVr2T?ᭋlFT xw7GWue1L1PLIO>JC&d=ޟ/w7hςaV!D-\H) O'gyFw1!ImjA%6'[PI Q );q q/8ߥ[RVRAGL(n9IǸW]+ pGDF 5oRu·^J?Ϗ+%OZ=Ts` P1QUlm ꐀG1aXMqgs-NL#/3/uJi)HKۊT>noj?"ꛂq9[KC-A`pF(5 RR a7bhZܑ="7`x&$E62KÅDߟzzfZ1lI˘Ƿj+S*Z{rM\ 2)x|Y, }R 8{,qIBUZwu[)I^NR"(/Kҥ(}sU5Ry Ka.r;l a^ű8\RWJ>*E %E$Zv2 r3fFVQ$.,njvԲ> p/4mH C^4,+=g| `rڅQ KS=XK1\яi/܌ݲ! Vc,>*GI ǹ:(6O&ˊv<8-f&|lF;i՟r D8x_E{C/qp&X*)x{[.8kτ,H=$c #UkipqܻKC.lSN) S'M6lb4(%#`W=Dݢ)Bvq=F")EՓ0gWSE# em%<;ڇY}9Jh69b[7WZzd:!iaKɯ GX[D'''UR}r يrקܖ7VݩWpeen.Jo'uJ3ReA$I5n8)#JN=oZ}JSI*Q8mr|Zy5*QnPXW+s̟JL\Qp*xY=>J^Kx2_?zToq)UaIr>m\(BRJjTJbO5WF+'Y%&oj*rk}y$m> qJ=mqⰝ$ԩEIr*TA