JFIF|Photoshop 3.08BIM`@PET Imaging Uncovers Synaptic Loss in Multiple Sclerosis: Insigh720260602PSCIENMAGUAuthorePET Imaging Uncovers Synaptic Loss in Multiple Sclerosis: Insights from Preclinical and Human Studies Science@https://scienmag.com/pet-imaging-uncovers-synaptic-loss-in-multi© 2026 Sciencehttps://scienmag.com/A groundbreaking advancement in the realm of neuroimaging has emerged, unveiling a sophisticated and quantitative method to evaluate synaptic density in the spinal cord of multiple sclerosis (MS) patients. This novel positron emission tomography (PET) imaging technique employs the synaptic vesicle glycoprotein 2A (SV2A) tracer, offering unprecedented insights into the intricate neural connections that are […]ScienceMedMedicineMedicine%advances in non-invasive neuroimaging"human PET imaging of synaptic loss/molecular imaging biomarkers for MS progression.neurodegenerative mechanisms in MS spinal cord1neuroinflammation and synaptic degeneration in MS-personalized monitoring of multiple sclerosis6PET imaging for synaptic density in multiple sclerosis-preclinical PET studies in multiple sclerosis(spinal cord synaptic loss quantification;synaptic pathology in autoimmune neurodegenerative diseases7synaptic vesicle glycoprotein 2A tracer in neuroimagingC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" K !1AQa"7Vqt25Bsu#R3$FSbᡣ2!1AQaq"23R ?jh(dk W}jU`T!LQu=lƹFūH/%!aJI8;Ѕ#EzbM=Gڐ$7!QEEQBEEQg04w;'weUXҰu3`pz(8wm98ӁGg8eEQBEPQY8M[x<\V)_ӌll8wpso:\3_B*w "ڔ]SC)QZxNrKkkq\<v=(_)X$ ӷm+K? "qRvwp[!]q HH }g7o/CFU X>}xV3I_SRNP~<<+OkgmK'zO쯟se/S h^>|yAt_@ÑpNS,{˃2GDJa YrѮ4/(MZ4(K(VV+'* QE|[Εosf'nOԷJմBU'G慰:)P-NX`gvIT^_dM%S,2JwAϖtt/)ó6g v\+FإV o!j#dh53H4qLL7$*z>>Fi PῶuITH OWo}pkh4,!#9#66rTzIyR_=[]BǯEm_`iWJ)(pA&:BU)r+~BT ,FVq0?>g=xתsǥ=t{<5c>=+5ueUTa;-0 Y Hf0a-- 1<JsL0ߘ= #{(f{IC~!ZS [<:!s{\\%9 nn]tM{|1R aqЅ,dx#t핻ḡ+a%grqVvgp]*( J|R2Gpe"'ڨ5i^U&H ޕAݾnxcH%>{F))*RN=c)XVR፩{^A|<`?TnyǪ}euT(Mº:a8M/1ߙ5OXo,v2c8r(kes+w)jk t+w)ܶ3]>Vث!sNaQONsp z>vz;EiCh*.uW.$2H|cI1[qf  NC= U86ԑ{h \yPK]$`\5 ^}yhyyv/4ODǤ)^IZ9)d:RJIAW L.{rb<ŸN=+CY|[oϥ,T կ1lK[_-{ų1S]'m,O ل7Wkk}lʸ]CF;N׳OUW<!Iy@ C7( u#bᗘJIwiAM/ F{Y=J,dFxT^f@ tڗ82EKtbE~:_ XtӞGg]Rǥ=t{<5c>ꆜ38ARNOc^U]L81vO-֧ژmPTH ud:1-LT) V;x# HXI9i[7ν\w=11K !IʖN7 5 :۽#')Q#:bun}czh)w} MRZ ЮǢ?ݕ5u㈬Z9%ޮƆA V􃃈%+mH=cCw>H%!Hm(m(GTwZkzt׿(3hA sm`Zuv=:46:0 1P'}sxR>]t-#Q:YZV-IPޟ?}A֢۠{mH?ڣčlM0f#^57͎P9qPW'KPa n+EIe si;&=RV%ަ==ObLoLPvp몄9.vYє&( _V4RO:"o@$o5%jL:d8(WzG IfL\} իdIB5-65 L"?OOq5z¶dqվn%̶3ՃMw b`;8mD q7s_SnWH]53C 9]f C`ῨV-%;+suo3QS%4NZFv?-O,[ĦaC#QG bflU5,{\קǥ=t{sٌ˪R,B6}mnxH^;sر ZC#xqBb%VH߳'~+& ބ45v@9 on XT\ aitjOR2Sm7-1|mAȪL0N|68?δUmmKRl)IHaS3pk>&˹uƝ8*tICA3mqnr[۩T0t9JTvJq dǺV5 :zXU^_#re`)+E9|Sȭ~h*-QW-]8HuP3L'ƻv+e#mMcc]'ZP g;B|L -ލI9 XZ0c!.0yt#b%*"7#mk|S`ːV|5m ڣT.I!=2K v[rvDJꔴd;UHUQD_@heEC;)U=~is}niu^]=?bomuȮߡFn*I\`R4Mx!kQʔɩA&*DBG!Y647K~l =Vsٌ˪_7,zSGj'_f3.+t..6܄Ed`@J%Z$E6tnwRW}$>[y'a@};覔uSHH1 猺wk)%4̴;ӪS- #Rw;]Zjq[ F%_}xꋫty"q!˛Ҡ{s+JN1bnd--B$o;3W\2AMMop'RL1#IyVmUh k-a Hط?7g|s :~{wiR; gwv;qZ+COʶ9[R{} Ff3*q19g*q_ӀTH ]@'R(*Z&dnnHࢦITOI_ujYew=S,{c1YcUW W ,,7EVU3O3BLNDd-堭#eaX z)xyo*Zn Eyo*ZO2 weoi %#獿h<ȯceoD_Meb(