JFIFPhotoshop 3.08BIM@Revolutionary Single-Cell Technique Unveils DNA-Protein Interact720260604PSCIENMAGUAuthoraRevolutionary Single-Cell Technique Unveils DNA-Protein Interactions with Unprecedented Precision Science@https://scienmag.com/revolutionary-single-cell-technique-unveils© 2026 Sciencehttps://scienmag.com/A pioneering advancement in cellular biology has emerged from Weill Cornell Medicine and the New York Genome Center, introducing a transformative technique named “D&D-seq” that redefines the way scientists map DNA-protein interactions in single cells. This breakthrough addresses longstanding limitations in the study of transcription factors and regulatory proteins that orchestrate gene expression, offering unprecedented […]ScienceTecTechnology and EngineeringTechnology and Engineering1advancements in cellular molecular investigations+antibody-tethered DNA-editing enzyme method*D&D-seq technique in molecular biology$DNA deaminase enzyme in cell biology/gene expression regulation at single-cell level$high-throughput single-cell genomics,multi-layered omics analysis in single cells)precision mapping of protein-DNA contacts,regulatory protein DNA interaction detection+single-cell DNA-protein interaction mapping#single-cell multi-omics integration%transcription factor binding analysisC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$";!1A"Qaq#2$3BRrTb9!1"AQaq24BR5CSr ?R'\K{ uY3VksT{L"J{Ի|5 IR)9I{IR )ǻ:GϢH\4]i}~1ASᑕ($g+Eiy{*<@ḕ 9fgzd*V[h(#nsC&Z2XWG>VK+p}]J}(3Tnyq|ל|BlmI.TxO6Y@N*SYR>e/#ʽS?ˉ9j} 1iY!uil>q2ɇhn:uyuҐ ) c¬H̅xi7(r=CMItn˔h1NN,CjVn-ɒW*^{ҽ>9p#E\v ݏ0'AyiI,L2v%{U*̲byVӍq?np)W|r ;k(W1npvG3kK='Nql S6mI'!r-!L`aE r=鯈LۡZV)pڔGcڭ}QbK&vfq?WUHɢ W*ٷq~(Hj TQzJ*^#U6v$ w =3ZiڹD-3Vtqdy2e)o9⸥擃NPR2jsPgbr{<f;fy pP@sɭ>ѿIҘr-FgSh M7H[egXKܐ2C3XhBe#E,E{}P[ Щ\zcT$4U(O;$Mk[Zav!I>lf%l|7f.vmZa%O5K1+) ⼺dɐ8V\޺I/;H*'eG iҺ.4W(mæxTGT H3Smv+>#[rF’z2L% Vӱְ֝eǒ#}Z0MN:d2p=\֑̈˄)ΥSh䂒O#Uv+pd.2n<ʔp'̟wV5[Ɏs; #Izw5 GdQHpD ʇTЁv=+8d)vPFr<$;eUi:Cl4ۋKY G2&tx!7ZT} Zldxyr"RqA3~괳5\(mY;l~*Tk:&#SdoQýQB!?CätWsB*EW.] 5jݙKk~*K.#sE6J jG==W)Vd^3C_&GvSa8JT+G}7&-%>3duu 8E*v Ȳbo#rRH885 ǻi!:@)*Xǹ}m=,oz\HrRL \cQZ ЦRBߵi!,dդs:i/uVI)ZZH[n#k\Q!iXyXAz t֥)Q0P?+!)^㔟pgcYRC;>_۟\70uyySȳKS*Jʑ<Z4myB8Is1O%VUeJZziXi˛P"ACѷfV@[=~'  liCkR>9?RCZeqSo6@S,`@p~יL"%R[rrI.')  ̙I ҰCܴ16o_z.jGC/JjZ qLi`zr)%JZ[9^=(R8ntAeGERib:U4ŗ]*hKڝyQK61("֋A&]5gcma2$$U;m%v# $(HW/Q3R`ES1a[V<\'zql1Ntd/:]tR31iےҔN8X,TIB$𖂼1RmZt, wMa“c\OE$N|k#4Ov8L;&WlN D[{T:cUm+LI r2K/dPj\|5!<#hU,Ǎz܌g:flvׯBe퓸{NB5VQ`m|F% %c +Vla2|{ -;A'zt)3qLLZ$4,'8 zu][;mM2H)Sg9?sbaK%:ɫ43$Y`kchq~\lպi܈15Amf[~JpR J_^d\$>Oq/r^_BT It R7)mr8BkM$@*n1P&/sJ%CjUU9C ֕%ĕd47@ʩxJ᪊hj8S*GK$0$:dB=i)b3m^;dvy"A8m~;S+JЅ9=kG&g쐄kt2ʎUO< y# ?\ 8laǁĽ;eJ<;ktmlѻ} 5bZJx>P|<(n\~kTJ$䓒jurrBBzx]+2:8\903OSj4QJ2YEq U1ExWCMZE%.ԉM2R!42TKY  #%sU˪-sQnOw.K[V*UhQVaòn(:k $qwzW:ca~?;y9=!Z˨V8PTc9Zl!#DKGWpE~3JZ̟NS+d6k^J II2Ǩrђ!QN!m@%@Za`zbl]$8ԂҀJyО)  26VrSYkmѶuK~jcxa-]"^tta5i6N1SD⠒MN{ rq\z$jrhjTp)4 W5 T*KE8tPH8x]QWOjȮklRTY(OAUTv2NܡQE Yn'rZ*-'Z2mF8+Eja?}o{פ[^Qm7+y|m%8ھd͝QEbS\J85EO%(QEˑEW.EQ\QEr