JFIF.Photoshop 3.08BIMBWorld’s First Phase 3 Trial of In Vivo CRISPR Therapy Successful720260613PSCIENMAGUAuthor{World’s First Phase 3 Trial of In Vivo CRISPR Therapy Successfully Concludes, Bringing CRISPR Treatment Closer to Reality Science@https://scienmag.com/worlds-first-phase-3-trial-of-in-vivo-crisp© 2026 Sciencehttps://scienmag.com/In a groundbreaking advancement that sets a new paradigm in genetic medicine, researchers at Amsterdam University Medical Center (Amsterdam UMC), collaborating with several international hospitals, have unveiled the results of the very first Phase 3 clinical trial involving an in vivo CRISPR-based therapy. This monumental study marks a significant turning point in the application of […]ScienceTecTechnology and EngineeringTechnology and EngineeringAmsterdam UMC CRISPR researchCRISPR-Cas9 genome editingcurative gene therapy for HAEDNA-level mutation correctiongenetic medicine breakthrough'hereditary angioedema genetic treatment%in vivo CRISPR therapy clinical trialintravenous CRISPR treatment&lonvoguran-ziclumeran infusion therapy!novel genome editing therapeuticsPhase 3 gene editing study0randomized double-blind placebo-controlled trialC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"G !1"AQaq2Br#Rb$345Ss%CTUcd)!1AQ"2a#b ?0a P=Y^IiŜ DJ\;^BISԗ<8Ҙa ‡]0;ҪRЫqNg P>TEEvnޝJP$e[s4R>Ӊ{ G ի\u/AI+OВ)Ċ"MpIErq"aPr)mʐ5 JKH>I\S#AAmVMN?r1JEq*XVnmYfRwT0u't*}k6(}pjJ")Fw&[߄壑rA Yj^E8m5ؠCܝS0Z=}&ԅn1F6O٘eU(wN)l*er .T;D N85 VbˎZ^rxV Sp@SvNyAM8{3$LlxiU?Y #]{ LVK%'cWR)}fɸeà Fᗸ~nBY 8Mo3VΒ) (ͼo~?M2,[:i JХ GM_DᫍݻYm@rJgɾ:ISCvSVVo:'je&D'L7v_a ա$\9xC7>BfwK+JyELX[-A8#5EsF`ݓ)<ꯋ{?!T㔵/q \pZc”SǴMd+?(2mb"ܐ7r2e~x'iIl~<`%P~ ŋٛ@(,>JhAo}ywyT1}zIiq4CJtdԅCu+ l3^Guy|J1Φ4dq8H#!#HR NLRdz3iGt'Ű%[(4J1dxa@|j8iCaFƤ&@J{ҳl+/L* %-Caq ^BJI%|e: HsRhc!?Rϰ B{ip e^OO"rLWTpqpV rfޡ507S N-(sHN8v8Œ AlCN2vIZ}_ 6%=mpRؓ@Zy|i(ongg|r~$i} VumZfR2#X_}xJV7#oHнתp'QIT\ע"vUyyҮ5yҮBf ZSݽW' ZYBi Or㾘f*c3R[nWFFcEGٚI#„,T\OiFK d|j瓭l<ȍi(-8"̹*b{ZjkC+m\1Tq`9mS`3bǩrbiZd.D g΍VR5nzc厬'qfԔNGƻ2R:'.D%5Z'1F ؃RU"r򪶸]=v+@9C˚Wq &RNp+SHHm `Uo]h͜J?mUmt <7~Uι!Zթ*MK\#)N ,JwIIt)#Kp},hI`+ 2ლz Mhr"4ڜ;b;6i }JSΤD7@C7T`U^7z -eCIq:V#^2ˏCiR*2^[BZ@B+UoȄRUy%'o<$R q8.5ty>nUp?dnkJ˜6*:f>Ȍ-Gsl*J,OŽ3) CjsSE[nEV#lSfCG VQ)TͲ]Ҿšq׹:2tQ;$=$T6d<'Kk$l~U.g^g: Z;jF烱$-7"G:{F G V~e DS`oZ?w mgIo>hVtk9j}ia[$s}*wb H!zJdzUZN՚ҥ(wFtC̄{4i-@V]Z6+ddP؎6zIjΚ$ kw!V](|%!DPd*{,m6TH be\IQ9`QreGgQ󯟙"oޔ۟*s"^Ì_}k6Se& +bƹ=BOƱ؝ MY,&OQƯ!kY 3N'q_Cmxj#b *.Gi):xZ(+D5t}lR2sҩmڏw!t+]ݲPS8Е'oCE}w>}[ގ0+=eARX= sz$ lvLSR ^UtBZCj s9 NWdWEd7IH˘ Ib5NGv[yIoD0jy㹷XaDƆϼ|I(^̸ܯ]RRaFf J[ݕh;E-]#m¤n\dL%]5o\D^" |xDyKV'Uri4,ol JM\CBoհ#Y; 5 7(#hgPUN&MF(H8ά~uE l fͷ**TҤF"J0q΄[NV6ȥJD|dR.-O+Ql J UqiGejyŨ8<ɥJvn8Rg ,R eRyҥHƟCRIW/RHHB>*U@c}*T<4UOyR_{֕*U