JFIF&Photoshop 3.08BIM @PIN1 boosts YAP1 SUMOylation and blocks ferroptosis through auto720260727PSCIENMAGUAuthorqPIN1 boosts YAP1 SUMOylation and blocks ferroptosis through autophagy-driven ACSL4 degradation in cervical cancer Science@https://scienmag.com/pin1-boosts-yap1-sumoylation-and-blocks-fer© 2026 Sciencehttps://scienmag.com/In a new study published in Cell Death Discovery, researchers report that the prolyl isomerase PIN1 can tip the balance between survival and death in cervical cancer cells. The work connects three molecular themes—YAP1 regulation, ferroptosis suppression, and lipid metabolic control—into a single mechanistic storyline. At the center is YAP1, a transcriptional co-activator widely implicated […]ScienceMedMedicineMedicineACSL4 role in ferroptosis%autophagy and lipid enzyme regulation&autophagy-mediated protein degradationcervical cancer&ferroptosis inhibition in cancer cellslipid metabolism in cancer0molecular mechanisms of cervical cancer survivalPIN1 protein function in cancer4post-translational modifications in cancer signaling$protein SUMOylation and tumor growth'targeting ferroptosis in cancer therapy$YAP1 regulation in tumor progressionC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" V !1A"Qat#267Vqu$5Bc&'34RSTrsCDEFb+!1AQ2aq"# ?6v6kVRBJx&uJMɎg^TȱSmb.0Olx19eY2.̳ i4)'U޹PK9S̥SbJn:U̓4fp饭m5?e6]~Yjwi֜m#B%8f0^!DoiՔ%ag*b!7<q;}0{RiS)V0B[±,r%, Z%&sXz+b1<Idj;m"1yѦJPv\PuV'( yy'vVZXl۫~%Lږ*m&r_v(,iSf6`96J=K޴،b#(m`xWrXv׃Wu3:<PM*[A4n^ҿY n?>^^BӇ#.apBzd66_ Bl辪EѪlFMWj5VCeP'9wplo~'0e1 U7~]R5Ĭy\$+fꓒPx(*Q@*/%\xӅvӎg6{_ԱuM.ԤLr6b"Y-"ZJ3]kp@kq#%emNk`)) IԀK+GnWw m.8ʒI/de#IjV~~F΋XZ5jCƨmIݼmF]@|rMx'9f<(Kb%Oz9MdF}u<64H)HG[|^~~m1UAI%t`nvωuyJ:_Dip&fgw*XBSߴY *F`:$YPQ-muc6vBP5ް}•o_P !7)=;T$$=)"15IeaiJ-؎]X!.8~Udv9LߡLJJVw,#HI7/($X Jucx wT@8ڔ9>k?!: zjj2.I"MХrWlW {2)r RZ"ΨٽuQ"W +K=ݕ[}NK]Jg-m G9Mm MlYz=C <٧KnTGo:߅ގ; -4s)Ñ-N= IF\B):wa.^Ms XDJQPRΣi%eҔ*q3 )ѓB<^ }K}!Y6kJ[ZR*,MRmNTXzY緫e-B μ  IPM8<(ȧ)W%>(8T%bF܊\lXpmU{i^ h =2p<*xKfY𦢣O-?.ïnKo9fql@X*K8x *r l c?HbZRܖZ C]̷:XP]aNL@sr#5`mr{Ɗl`0M q@xR 2Î4!)Wі=q~ T,@)ϸg\.$'* Qrk|o-3EcøqTTmո uHXoZ)0 PKj)$xrq="Qɩ-@ a|pttqng -(˪䛓ꊀbTCO3RۦI-RN:RnZHG~RQG.ؖ<-5`_b8~V(@P THG^OUR$p tܳVW!nȋ}!a9R@9JGej{&(N41-my$pqg)*m=<5"gJR-fIQ\ tvɚ,Kld&Z.NDԩrHq<ϕI]l6J?I<=/92t] ; ]=*cYBgMZ7H:5$x>8wJQ:nR/y6ƈSws }1+.w&x.H KV´g]OXRJl\~0G`T-߮b:$q 4\ qRGio@ޖ٦,XvH |f$BfNnVjZoFʉװ`ivX[< G#9g$c{!9,b{ BSg>ay='Fsm٢]o\nӜ&JAƹ9t[zR2 '8i E6pH.=j{/vOzݦRu^]Ե(n򃪉bub^@UcE|ΚCZG G;c.F|cw$D溏T*Ü^8(mxeJ7%⟽|L(0g?~1,2߅GTiJ<7,̪`@p$!N-(Hl~*VLZF0Tf^?>xD>x%z8K;)˾6f{4d̜O>"4R)0PqM)JI{ g7nMt'߉'CK>e$7+cxs9GS@-id$SQziKxߙD3zdQZns'wN$陴tk]&e6хypp.oD^LtKGmUe%#kEsmQ} df`%:/ޏP[=iմF3(gQdv"CAM:/T0 (QO