JFIF$Photoshop 3.08BIM@Nanopore sequencing identifies parent-of-origin specific age-ass720260729PSCIENMAGUAuthorNanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome Science@https://scienmag.com/nanopore-sequencing-identifies-parent-of-or© 2026 Sciencehttps://scienmag.com/Sigurpalsdottir, B., Holley, G., Sverrisson, S.Þ. et al. Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome. Nat Commun (2026).ScienceMedMedicineMedicine'age-associated epigenetic modificationsage-related epigenetic changesallele-specific methylationDNA methylation analysisepigenetic aging biomarkersgenome imprinting%high-resolution methylation detection!human genome methylation patternsimprinted loci in human genome#long-read sequencing in epigeneticsnanopore sequencingparent-of-origin methylationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"6!1"AQaq#2B$3RTb2!1A"Qaq2#Rb ?Rf[JR)JJRjڮM3Y})X)@)JP RT)@)JP RxiGSkFaeqRw"㨍@e~f_,avn/jս['Mp)еUy*`TJRR$/4K%F3+ 6GMz51CjyYf5Y7L"@pԵk=}dz Jթyg[6q&a.7g5s:]W1"FDj[$FqjujMFb!*G{«r QcQHжvf89#XJ74&(h@Kd0=8+jn|}.ӷw|gޛfU Wz U'cZ*dt6-mϥD,K3 +0#Bq&!6xP 85AY-5lYnt}El>ߊoi:NKݣFt޽G7so ![$D`b4^돤Z,@>4(3ɺϾ+y|p}*Kx(&=}2ogLMPyR/"_#>*@m&hðku6%o,_/4HoSϦ Phv\Zm|Kh xhlsi|t}M"cqۑ֥缿y^<ᱚvh&x^WK Mpd̮bb\°פKceQm ˷⹫ mYC6j'9.4K9R #:ZWx|_?3)7L\,I$֥L<$3Dm[Ҧ)u+(,ܳFI[W:i\\#@ )kttm/ŋk>ϫ,V@|CoGBQJSGhҜ#*2ޗVɹwJFcFli33j:gXDbmJtSp )jbÉ[h Q|fgIntY 72?ȩs_J{rFjVbVIԝŽ5=:\Cjqr&Hb-Cβ ͟/r\NT$kxHpUeXi,Ҷz񾗋$DE_ْ߭?p9>GRw}?IX<1,aHM$ٗ&ټbm6 ԦԷ톜=mʙ*PHIˁ5;eUo4$' ؜9l%>@ePQST{~ƶlQ hvNOwshX],[N} rtFa,[1 8<kz.KC6gՒ[w۫tlS ~&8oR8=&.PKam 23۔$c6-޴IVg?Ym}ބ$QTfs6.o0)$rF228`>~!uE0ig\w9=V=KȊ0[׎"zqu+M][QԴ[)7|.bMbl,e }v'ŽfHf4vp;V-m8Mk#7Æ)ʵeyl}-5 RU%xtyc^gf~Ux֕ZhNncqBs-;>Ǘ9洔/ӓǞkrghR?r+Ϻoݭ}&tMmyoF;?ޤ!2_2~jۂ#[ml\_;⡯{!8򝄞A8}jK;8ܤ౟ޮjitRU6;Go-afA3+CQիGUČ1S;/TjwS^YZ$w;IjttBEծb> ϶O5^KlĶDq ~GR/:WQ5zʮ<W7U*^TWp[_~d=rHʲR[5HH7)#W2dr 1QU'tA9Vgw)|Իqq%tP 3^X|Pr}<~k~NcFV{n0 `8גøJX!'a]RzJܭʹnb[r0>վWնcyG×Ө"L6w 8b 'ڷ#:`]c6dg;4Dvn7{5Jt%T_"c@B