JFIFPhotoshop 3.08BIMAMicrobiota-derived 10-hydroxystearic acid activates PPARα to res720260730PSCIENMAGUAuthorMicrobiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy Science@https://scienmag.com/microbiota-derived-10-hydroxystearic-acid-a© 2026 Sciencehttps://scienmag.com/Kramer, D., Santos Rocha, C., Gaulke, C.A. et al. Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy. Nat Microbiol 11, 2365–2383 (2026). https://doi.org/10.1038/s41564-026-02433-0 August 2026ScienceBioBiologyBiologyC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" M !1AQ"aq#2$B%RV4CTrt357du1!1AQaq"#23b ?MVOyN VhʁtQD&L;He+Jsץj]EIԏ R5AZ.ݕ(RVt$9;fq q}* HRHRH#k[:9\<Q?i@|M`d? I$Iz>ɢPJd֛z_f%i) Bg *UaYG 7)K*t<]ŭ ˻kb-?6kL 4jㅨ0&aE<y6M(ux(i 1L)GS/%]mV˛a(1=>xX#*{bC ns.e&d.Jr mb)?S%o{J4e\H}#%{:|6Jl7ۭH*ߏj<2'8g=t[mNq2|xBtO~\p_vBqӥ)vkqrڂU[OAUCЉߺƝB\BGT2 ;lY:wJm 5`ZaaPSBpF0N>YEt68!*ūK(ԭ!ު<?~s6{i#!G{j`29* @:1zI<}%aEQQEBQ\9Z&>! +PH8 !9.mKn+dOy]|zx}ճ5};AVkqz.BԬ##j26c?0~5Ms*b3-Dre!I#jRva*ڴxx"ݭnCDFgs<|V-VVۛOdk? 2M=(Iz3]R=cy>=x5R{MRR-G*UOjMjkf<ڙJaGUMeյ',+R[[¶-aΊLMMثw=Nk`=>􆁸ޝ%O٢[ Y\ =jX%Ii\Fy]yvtQf68m-_v"7ҏVFml'9IRp9>T3rT#3?Y&j~c{̃6ۖ8,ɭStR#$ÎOv$ `S١ %"aL!eܨ} s* CwXu#{JkH+HamQB  y{=C!6a)%jH`q2~yۮ-T0rnO ]Զmm;c QMuVyџiT)'V2hJR@ʊ!3(*1v,_  u*N'{sa!(ʌr@LiW6H)Yqu "کIܛd OY#uo=Ǐ RZKdPcq*a*8%Ja4I=HHk{52m#z1پ'2ӥ ?X7 g98[TG!c9 {#ǂO=*BYKF:+Ng۟j^=JsK[&j֥BW(Z#z) V * J1NysisS U%թKuV\R՜JyO󳚛Gd629w^Tz{<vQ!%gv9ǀ[u ܕ!ǻͥ6JgoOOg5#1Hl%(8<}O8f2-#HRvFTy *X%kZh| B|BpBh6۳ؤE1 ܞ3Њͯ#EOiݺ63ҦNۭr[!wyR厸P܉%]aqAY>G_LJGh"fƆ+Bp`3:Q3:8dKJOrd29;'q0U"Co:-%e'ߌ|N;? HjyG+%1HsS%L)UH*QNJ:f[!VTNC Há`Ś%?9:K# 㟍"Y mP`:+ *v-aˀPwm"Jh<WjFmIYQvie %PVolڗUB.ƹKf;a Z7Aʴ9-{9|;kj7Hޔg9x*ͽ@T$vߪ \"4k3NGw-/9O< ~DrLVz3XTP9ꍿ6 6@rtլ`+aH޴uRea92d&'iZ/p^L,llI:V,-~A5,n5}WUgxVIױNZn]W~} -BxEKtuM91i.3NPʪzGK/hM˒zcMU+\K8}V]@'bڕdͺšNOҷ;_CQ]ڳGu`{_iٞX%#bVpGW'=?w{Y{-d-ajڞ+le6ZLv7m ^$V]Š( (O=:6zQҶzB$uVSsOk*͹(4GO&p&-0 ҵ±9ΐvA&A]ZvVry+J,$9P#{6 _hZoh+:+sb\{G[}ۏ,y ?us4|k]:S;8$Ng4{):m.P2zJ͜ci( ֬z}3 iR7!V/[wLMݐPJ3}$cšJVG'Ai},d2CԨr9kQ`L]7hs 2c% Yȩ/Pv \=ĕTS=iղ81mGuH{IP@NA䎸UW2({JJ?MeojD%ʊ(Y9=:“ƅ+1r4{`dxy՜ֿ݄d-*b+Ai mT'Ă85*iMjf؇>V:Y+/wٌ!EV0QD!EQ%ռ K[R}nŞ2?*(٭ʲkOYZ\joBAJ(Bc3c$fVCMXs[GEH1b~Uvޅ7+[QEfhaR$dmB((! (B((