JFIFHPhotoshop 3.08BIM,DCD8⁺ TRM–chemokine axis drives liver fibrosis, reveals biomarker720260731PSCIENMAGUAuthoreCD8⁺ TRM–chemokine axis drives liver fibrosis, reveals biomarkers in chronic Clonorchis infection Science@https://scienmag.com/cd8%e2%81%ba-trm-chemokine-axis-drives-live© 2026 Sciencehttps://scienmag.com/A study published in Nature Communications has identified a pathogenic immune pathway that links chronic Clonorchis sinensis infection to liver fibrosis, while also pointing toward blood-based biomarkers that could help monitor disease progression. The research by Du, Li, Wang and colleagues focuses on the interaction between tissue-resident memory CD8⁺ T cells and chemokines—signaling proteins that […]ScienceMedMedicineMedicine!bile duct injury in clonorchiasis(blood-based biomarkers for liver disease%CD8⁺ tissue-resident memory T cells$chemokine signaling in liver diseasecholangiocarcinoma risk factors%Chronic Clonorchis sinensis infection8immune cell interactions in chronic parasitic infections'immune pathways in parasitic infectionsliver fibrosis biomarkers*liver inflammation and fibrosis mechanisms*long-term effects of liver fluke infection"parasite-induced immune modulationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"J !1AQa"2q#BR$34br%5CTs6DScu7 !A1"Qaq#423BR$ ?вWʸJZT(^ ɯ6 `Snq"f^\ڬוyɮRҔ9r裍V3\ V'D$ͬ. @ˏ:̜SkSvgd_k<~T7B>Z5== eQ_>E)(eqQʊ19B[u&gjmvZfUZ^^iV2yP-X$f5RHCٷ-6pzq8M*hrZ"3t~' -1e?BP9)*D`5vP& FZLӝ!ee*TBaLkkUzR6'9dնj-_þ1e)1`# n{  ^4w{w{똯eҦRPRV_YXB±Uʪ2G Ag<3M+_PFQV*QRI[iYp_3~X25(܃ɱx$Y#}(b8Iv;Oz<#4~GxyQw5t C$9=F:EWZmϥAIw0UJ67;9߽RHUJZQJx#3%JU֝Z.єpTT><Of\1+rG&45s?3a-ueGd Znv++pJT *DueV$}݈)Ix*%nYd_Ki n0ÏnsB:yҩڬ<}EQdm)lG:BZwȋm+MBe4NR}=DhS,I#ܻmRX0# UjR͉^dwPM_]>+@|B߭D!HV#hČ]|~1ԑEWxX$w+z8:mtr;*BH>C()#5\]zfXm3AI-DyDHi f)r2O^nbpwgAZ>; :}6Tq ~KSiK։"\ Ks/w4|RuN@q5ʻ4E?cPeI%:Ak\u\>AVG#KWY=!j*'&R5 .è(W~cxE\/8AAR J'ā\<&AxO*%Q[:!LB[y/8\p$t*jlE,$m.$u>W>պ%i^-`<f#o)m$?urMb_ʐ~JN,.ü۞C;#rsRk1 uʂN1Џ;j d:xWP6> ܦh,=ie(Hqʊ1`r݌]%e y~WhP.l㱬I<*,mž%Ŋ%-['=҇4AQBP rm)m[)F7`cVmkw[kP\}}.T3:T*B2ut9\w09̸ʿkn=GO 4xMiׂTÀ'.5[V) 4ӨPV/FE4Xc=jSp.4Np:1T)7=e* /ø엖N'jpGPh-ͲBRy n9jfߵmM O$#-{1jhut3B:{qd̅S0hza"`W%C5%UȌgʜ{;V}^h !жVJ*TEqi4́ DgCbb!0GuFYm{Y` `/n}'k깒wg1ۧph#<@EM05$ഩ#Q!) sYc֨g/4>`Bz~rpm}p{Sc {M/V9?=./}oIkILK NRw)Hvr1Q#6Nj5_Wޥ]*=7m%#֖k*S[8s>Y\y6߷{S`6E?E)&2TJ}JMI-&vX+a_>e?x ۠jhVЂpgDG]9͉8QPr9#hh4왇:Wam-`Ǵ{KXf%.!! I$VRBPy﫺WI A!=< t;$)-8>jj˚x^uxLz B j-p<IRMxÁw]gu3oI2C>UoX0`Gҟjǭ=].'4D2zMԤ}mFmR ~Lm ~<ϛ o_1^2Ŗg )PF1E6><)!N =O*ƹ5|2Ɔl!p'#O BXK]g9;ycΩN. d,H}ׁN֨vzQ#tr@.ص<+,kKtHq8R8` Νm_gClN%#)^H/b}J cKZgpe3񺙄f-EJ'$kE(-n?-~bͤn;*XEDʸ:JE. 癡G 6#7(>mh1j,mI BI~щy#vK SkXKJW줩eG>,FAc-gR$ Zh[LdҞtn{yKtpk ؟Z^E"5$rJX3U=ד7]v%E.lX-@#b=p:TvceD 95DH# 7-U$R[ _3lP4 ڮzzTeI}@susH Ibxʎ ~McƼEm8V i8W"HFCZžIq$FȪ4Ԧ7|7wֶXȝyQ4MJUߡ#=<"j4CP ay5+[mJ#Z@; j8 qG#4* v[Y.MU`Ÿ2qJ,9Vm5#ஊ$nilNVA[*Q2NjRbnT0\_I|4<c5nZ+υwVo gz{L vF\vMFMFJʺ9_S#"Gf_ pˍiw_57M@l(9mO}NO~ NE:8}R*od < c4#ʵ_;%N=DuC:R A8>4fta3)Bp qJ#Rָtܛ*䄥F =E-Z+Ȗej\X'9y}g͟aWIAiBǻpgj=3LGNiJ$70(qh2'~, ;DqBz(tJiS;A9)=/e gWק/舌yd7ܝ) K?‰ǗIVЅv\=Jy2=+s+ w䄶nB=v׈{f2(\=MN, <6Z EJ)W4F:Gι`q~: VEHIqǖP28jWJ'\yӖlZmW;:9%4wx*\Ĥ '" v r؆"I_;-d[W74tnR@H?ZZ!V٦0,F0Bx}([s:FAKb> D\Z|Ы}CTv]yӟj).,ԢI x䶥RNi련f-F<\r֓)2p㱦 DfvI<7SIA:ʙduR'<z P=k"qxh8qנ ],۬2=(ǁ+5[l+)Yr(`5p<<0Me1Zmi~Ee0' Y]5JV.!_Z68QSJCC  *hqƥ~RI(- VG l&J$,%Z5+.Wq57 Ci 蒍8?Zӊe8 IBTܚV#o ,GְPw|FIU0ay=>@'='0xiA6zxB>Gu!wn)4f*N#I x}jPʔͻ1R~.ˬulu[ҽҩc8&c1+KQ?)9 95LYIJیW@=Jl|Q.crb-ZdhﴎlLJʾ:U4tG;%4H > `<:6坦bAݏ#:敲ZO ZSj*QI9&T9+j7Ri(Z5\brb3ٝ%_9u pBV56[UYA`8ZRҵ _nN\"XS ԭ-W>/h9J?ly'![6+ِ.bGGZpuSٽ8ivX4|t6p!KF7Jqfߵ1 pq9$Έ6h[·JV I aԡSAT; -zRz+'},٧LCFՄ+i+/Zoterl9 N1I+7o8)HvZܰ8KnP*|pV{@"mIT8zҳDvO #`n.+g@ĝzm>RpeG)o}N k+/5.ڐII!J&aA>JZV_f[S%|T:"LB+V~3F5'Q=2R:ߔ=$%4rJ&lJ$0?zGjT?|S~S̛Mn^9x-'P҄ 8 7rJ?@[ nFЯ{Am B2#ٿ:{