JFIF4Photoshop 3.08BIM@Pan-cancer pro-angiogenic atlas reveals tumor-educated pericyte-720260801PSCIENMAGUAuthoraPan-cancer pro-angiogenic atlas reveals tumor-educated pericyte-driven anti-angiogenic resistance Science@https://scienmag.com/pan-cancer-pro-angiogenic-atlas-reveals-tum© 2026 Sciencehttps://scienmag.com/Anti-angiogenic drugs were expected to starve tumors by cutting off their blood supply. Yet many cancers eventually adapt, finding alternative ways to grow new vessels even when vascular endothelial growth factor, or VEGF, is blocked. A new study published in Science Bulletin points to a previously underappreciated driver of this resistance: tumor-educated pericytes, the vessel-associated […]ScienceCanCancerCanceranti-VEGF therapy resistance'cellular networks in tumor angiogenesis)effects of anti-angiogenic drugs on tumor*mechanisms of tumor blood vessel formation#pan-cancer analysis of angiogenesis@resistance mechanisms like tumor-educated pericytes can promote &role of pericytes in tumor progressionsingle-cell genomics in cancertumor angiogenesis"tumor hypoxia and microenvironmenttumor microenvironmenttumor vasculature normalization tumor-altered vascular stabilityC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1Q"Aaq2#B3R$br0!1AQ"aq2#BR ?EPQE!QEET䉣 [}- TC#mՍr#ޤp'EolbwWt*ȬT̫PF-+^UJQE!QEEQBEPQE!lv3j*rIsRhe E#-LBT` Szcu1197&s3j6 G.4J;#RA❞SY #qn"0Lˌ g9hH#neN6[%_{\>$c2ϏqF'-VS(ѕUs ڣ\l%/qZdVһV֗2&IK>K̪ u&ŰܫvCk#iS?Sڌmز4̑YSj]= k 0,23ȮDm=ٱdJi tnv0Ԯ-$Cm@#PʹԄ;BZwڂo!\/>NW\Ne]Wj-_k`Vƕ%2IV 4egAo6̛=->]&]:u/[[H r>* e0ˏ߸[md+$GQ[jwi/9a#->ýdZKpiJeѨDQPdzXC_fyY1l fXٳN9bمX^lqZA m 4,s˨~cbyhVII Tk'$Φ,X&`Jx*pCO\SvA+VU{_ cr8d5x+1l` O.A_=eG Fiˋ祖l#jieb Y oNʦyN?:* qޞIJ졌]FN2G=/D-*G@XKc "~fh1F#AcZZF&$<֬?˚*>ߗJ|c%ܫ`bFئ표 ZfMO{("v%rH~I_JR9ܭR TA ۼu4/;uߧc$-bq_%c=hZr a Ot2R;X#v s1YX6f'5 J10rIZ:fM>!xmBhayb\5c(?<TG0܌b9 \368\%NEhdFS+68̓TowtŢ ⸰Uf룱TXk@?zcHƽ8%"R\ He=GE]z653\Gl7HG#/i,ϊ&z]sNUs3iyot/: ͼ_L2a-` ?*ma,l˂yѿRѼD&Ln ec;z.~1M#P#ȭAշ}mL.1{ܬie_N\Vڒc:ֶ}GT! ,hHXbot;OWw><տO clΠJn1>NY=< C4{kX/ޓ/ύ<1Q6{WSG57#LH@</͝q\F)Bx'{՚q3^3*{:UԿb:OA W吸^I7y;G+(I5ZY|U*3ikww{$i='i{5B zHS+jŔZl/>gOI,pwW+/NM7b1G"m؋԰jm~Ye$*Hߏu໛-[#ؕ]$.܁2?z[R*kq[]KtO$,$Yq)}N[i.$p:?+ [O4OT {{+9fydwĒHC (k>!>L|9 SL 3cN*^v233}M(קcIyROyV^@"@if NV-w7B+T\a}8} Ǝ[y26ʚHRS$?m6s+l%C] 8FǏں=[Ɨomtr p…&>#*\1,`e$f>jspO؀394:@{`5b(YZW^B]C6WY$xXxO&Dd#twuNK+APmxWtY~ٮdɍ!a<IJox?[-]G/Eo湛X`b؎(0ZtKu{+$6|GPsx) #$vl9 CAO@s蔴Eld*.#LGTmR>DcdRHKrU.ߏof2"Yl+) 9{7do*UtEv3 =[Qy?DU mZŌ.]_Ю9u;9Tnl%ĉHOVumor |nͦYCz F:'Q c'f>RkxǦ]ͫZݢ(|j 1Z( aH$Aȭ]:k7ǟnՓMo_0rkg9;xSsA*0.5u=Dɶ[zzS<؜sRH$raj9-b3NT3־hqD̡>_Ah%,{OZ8:8Y㩴WDGf5sNnHF)ڳ2kJ-rJ:Rl]Q\#8Ͼ:Vc$ ۘoe9RA<X(\데qlպnqܭͳjN)#ωo$/О-𭥾.dqNK'ppWkk$13?v?xZL>5ȁvDĬcHc&M!yl>uiCh$}ES QE!7ۆҡ95 s(6N˲ Pr_Qmj? M_}$ #F#n쑩QUY?gqhLۇ]u=.YKʉ-Ң7w+v=n_ {ݜW'!:&P埿+Eh#+PkʮmSRyw( I9TcJKW rzהQQ\EQBEPQE!3^)tS)O]^ڹEsY]律(H"((B(("((B(