JFIFPhotoshop 3.08BIMAp38β-Mediated BiP Phosphorylation Drives Stemness, Chemoresistan720260805PSCIENMAGUAuthorfp38β-Mediated BiP Phosphorylation Drives Stemness, Chemoresistance by Suppressing UPR in Liver Cancer Science@https://scienmag.com/p38%ce%b2-mediated-bip-phosphorylation-driv© 2026 Sciencehttps://scienmag.com/yHepatocellular carcinoma, the most common primary cancer of the liver, is notoriously difficult to treat once it becomes advanced. Even when chemotherapy or targeted treatment initially slows tumor growth, a resilient population of cancer cells can survive, adapt and eventually return in a more aggressive form. A study by Xu, Huang, Zhang and colleagues, published […]ScienceMedMedicineMedicine#BiP phosphorylation in cancer cells&cancer cell adaptation under ER stress*chemoresistance mechanisms in liver cancer&endoplasmic reticulum stress in cancerliver cancer stemness'molecular mechanisms of chemoresistance.molecular pathways of liver cancer progression(p38β kinase in hepatocellular carcinomarole of BiP in tumor resilience-signaling pathways regulating cancer stemness"targeting p38β for cancer therapyUPR suppression in liver tumorsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" Q  !1AQq"2Va7u#$3TUt56BERcrs%&FSd(!1AQa"#Bq ?,my54%;$؀rbZmE+}rR0J>)&+XW+wUڝJV,JRa& -RlƦߔ,8SiE nf Iq(/&̛gt6YKҊ'nkށۚʫ^IA^DɅELJMhT^ì@3ۚEq' +gMS˳rm GI j9^0Yv_k&}S^X)+;aHP WG&5\m3%G0]fYkIIZ"17~JJt$8JI oGkd*BT^9OEо&1_0JD#j&2S*u:z RKײHƾ`#tp`sgDb8 eAUn{nGW&9JR)ιEdoe~1$KaͣV8f\[)f ޹aaӢdqD]RYJLu;ܕahDO-Mc0nrg~rKArme /1 0BPm4 zlZJna啯xSe<ңCr] q̈&E1)H[Ø M+Vb2! N~>YLѤiӏT&˭%\uA ί a^ 9Q ܒ $Vᙇ\ 8إ}NT,\UE,JigTPyZctԋi.R{W@,EQ !J0KVuG!&'Q py:>K 96&ܨiuMd ^scOPX-"G֦_@NVRù)2y j:^,Y!f 'zAVn{bCC튦\q2K67:i:IXk bOH*l 1'~sH@UQ0MO 8fVTR7 bHo*ql9h} SR: uF܀v$Uc˘#O*ݱl#{J $1.@َ*L2ʛ.,!sK)P.&u{bvkkPvŶUŽئ,q,T/8{7-ycv$[qaDe˞wԺl-yR^jJbg~\*!jNҽlhKk=@I<ΕQuj'?^ZNy:”^PtWT, U(JIԋsT왦miY7穵 m>se/<}{^q|3JٹlXp>HsN ʱ`kbĶ4=BX̴Se)M$ypu%9Z-KR`DMkEG//t2ĔU`&&$mW\e]w;@ VDT{2u-o)(P)S6l5!U{sҺnwހT7Q.*nZbdO)(tf^INf̿dHLsW,Q6GWTU96p )zaC%CƋ6۝/a҇=GB6V GՕ\f:.3s9Df`-oUeJIoSsu6\9'kDͼP+(n8X~Іq-՗v,J\H uwnWe:2N}HNp 늀#uVS6o2E: t2Õ䙤Ϲ2L-s xMaq[*ny/4ң.~h0Lb[;prtblPWduJߕZDm0ZrVJYˉB֔Uaqqo=4_UeMinCB+ؖ_TeCr[iŸ K@ɱӝⲊf*I.}s%I&@HRrXsR掠R #c-ɝy ̠,whS}nJAhDn3j|JUj[v7908DT=)m&:|VTSgF)&ޱm:Cz Vni qyRs( Mʵ_va㕤I&Z%9_yƯLKJI?.Q2+) iԩ1>'wR|qT{W=moD/wVvX&_DXc *tɴIJ+Z^" ɉ" bTZN9XZO1rL NJ:X&[H3L.3Rr7x6UŤ\INVWS6~Sݳ aw?M| Vʧiſ)f-bJ~+i2s7VTy nmh;rbpua%Ra %6YA߀)PQ-oR (Bf=;) jr*8Xp4ae^r{q8YyojJZK MYo1.*qܐͯD,a6+Ԫ3(lNTBO~ X&LˍeJT͈R&5<]nNENܶp Z <;JBBǮjVjn]2Z*R{6 *QQlTtGbv`9l["'7&e+%6͍!:r 7'@,ohOs8r5"ZÎ-L \?O8Ӎuh $hz!*j[M2̰.u(QY7 TF)ZөNm [6II'E8f}rwP8`C*9MIsnQ5ߎ2tbΪX? զ7R&W`f%Zͅ/pGײYc T&XCͻMZB\ 6= ŋP;^/0GײztbwZjKNI$p-Ȉ&FjQDa2%]RVBQ^ċXsnz/@M{"m, VAe"f.d'0ȿGz/@M{ x>;^ȮA[<ӴݡawrEHiQfq_O$Ӷ[h,+0ľ4J CɶpACvjo ѦuEn:jRxH1da;.af,d2 7hQ7\ SDLYF堣)d/=hHBHg& 96z֤aJB~ 1"OS'(%-k6Q|!RB ˴ q`HÛRel6m2 ~c#6l0 rmX4 k\ϓ/`ĵÇ驜 %˺X ׼WF1ʲzm% |2|H-ATY,UU'ٕ*+ݸ3ʷIT(Ӕ4jiKE~e.%?. cj-y|bMB !RB֢eJT=h#b(\sks/gI*NB3 I]w腕).R:1}G.a*"&rjaOʧM 1X786䭴)YG-@ۊR&l_U 9mQWOZEf>첱oU(g!@j3p%MZK.%h&P\lZRnAD!i+3[6@E*vRaNKM_@'BbJy$tZ4$k{%O l(qoT[\d#1s$8m7 ^ݥ5",@*!Xk j n"8RU'-? U$EZ$,^YSICC6m%\nE r澼$$W.l:VR Rmd4% WEkZΐ;zikTidB@ ( ȅ~ѭ)(,6bIګ,.8¦,hLBmFy&[l{#Ks<9<7aLUeIKr oSsuaj!WYj^UeZS;ߐu&amhӔ%bRTӌ6P`E/xk*tٝN#K9YZQI$E&x+&d_NMU$묕dDBq-n/,inj!a*>aP!+HΫ߆[S;tU #/954N(a=F*οTAS19ĺ4pcPHOLoZVALȎkP @< :x) @EY$[t IA:R:d$t"H@Pu <,,5Vh AQ6z