JFIFPhotoshop 3.08BIMpCEarly Parkinson’s disease: α-Synuclein disrupts co-translational720260806PSCIENMAGUAuthortEarly Parkinson’s disease: α-Synuclein disrupts co-translational protein transport into the endoplasmic reticulum Science@https://scienmag.com/early-parkinsons-disease-%ce%b1-synuclein-d© 2026 Sciencehttps://scienmag.com/Parkinson’s disease may begin damaging cells long before tremors, stiffness, and slowed movement become visible. A new study published in Nature Communications identifies an early molecular failure that could help explain how the disease gains momentum: the Parkinson’s-linked protein α-synuclein interferes with the cell’s ability to deliver newly made proteins into the endoplasmic reticulum, or […]ScienceMedMedicineMedicine;co-translational protein translocation in neurodegeneration)early biomarkers of Parkinson’s disease/early cellular changes in Parkinson’s disease+impact of α-synuclein on protein transport/molecular pathways of Parkinson’s progression2neuronal vulnerability due to ER transport failure0Parkinson’s disease early molecular mechanisms:protein synthesis disruption in neurodegenerative diseasesrole of ER in neuron health-Sec61 translocon dysfunction in Parkinson’s1α-synuclein and endoplasmic reticulum disruptionC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1A"Qa2q#BR$3bS9!1AQq"a2#34R5rS ?6T yRV6=5mD A+)J°2*"#> O-Ư˸"\}@ dUaʥ QW׶][R()$v"mKoĻ GC_aˈRu߆zzL];* 0%N!EC8ځR$1c=y䦹tv )AGVU % [j/]Q la zm#N?ZjqɄĤBr3$~4a1(gN{V!`}(6ރ[AA1*$tP־~Pxi1vCBZ U'{WJMJx[- mE+IJ`W+QEPUE@{ڴZDp*ZSOXHm$6@#9w9?5Miv_ePKGZY )9XG \vX؃p]RD{u27'=P{NrIR֗n-i&TDoEZaku=Ml1mslANjFE,6Ve=b09'z^ZSqi F#$u';4O/x'Oo^:`t\[~/B]3 * g&CQd`c>W6:Q0}K=+.F؎댨 #f}9n'U<2BqDIN{xϥ0k/\x3FTx6^+p {<q $.;ͿR {698XHncDu,xִY-ΥŬ"ҟNWXg 4@I<6z޷k+mP5/?ПC'ix;ݎӞH*#(&d$}Zѹ÷j%4P>'0{w$Ev\k@Z7=.YDxZB_'ZnW9wiJ1'Dms{1n %VG&W -QmkC\`6Vqf\+R) W|%NTzeR]d(xi @iL{(CB4LXWEQB Y~<֋-Hm8s>t%v'xx:i"G$."دl53LɾiJ i@ӀrOwYS<"7'*8 c'Qsd, )>Dp9=U4}Ji⻄s(PpN3>zge6!S%h畷sԕ̱ap9x'T/ٻ&JY!IQ#n:R/:P(qNKX Bn"CҞSϸ]YʖkUU,CŖg}qZ袄"(YǝħִSU)S2<nWqڬ+cgQl:F2BpOnΖw-J$Pl8JA;iipqMV-} 261bXAq!Ҥ#qH(BYr[ZdZzo{F}BhZ@[,PcQ0w2RΩm deʷh! |`W recW}.}긍(R8 8g4]=$n&ſcdY'LVէ\Cnb%E%IzI]bhUL( =_\v@Gc;mS!%|sw5ۂb=1jZYD1S=NkV>w#L0ҠuK4jU|MP *RTW)[]@*-:G{Z=V`ۤMyirb:|mNe7[_TuI;NjٳN7?JX]Isf[a۵^ݪ$^9ץ&I*D6Qhut2V&#ECM#XH@uoJd_Pme \}8ԵRv+K,eQ1͎C&KAExyY$3kf08!_ kl9yԧq'A8ϫdz)Ye*@Ǘʜ}tKcNg6ZwxqYrzg>_h\~K+q A$#{w բj$}Ln趠4n7=T}Mq͹q %nud88O K>ԆhR[|s XR~<*|s T[l[*92iZlvJe䩵ACⴥHF<LSܵ7ԓ}.IJV ~.uS#ThXQY;S }QْvCK&ROULc=S[FSHuUͣ JsO]_*Z[R%k1uz5ތqE iF#!dB?gxcWFuL2;!*mn RԐI@'*1 .1!3sZ޴7g8X. &a  Fyҏi{'qn!Z˿$Knie9ONR5gݮW&DvtAw+m%ntrl¤RFT ?ϭ!jqjZ*Q'өؚƍ6dd9ێ@8?!.qn,RMkMt "(Be'5DMeDt_ڲ愸ImxN T9 ,ԘWpKsQziD#7?a_s,Tin egbՋ]Sn<%-4-}$ܓLVXM`&KxpAH[Zg!R6`w8MSpHݿ':RmruLR%VlEƞ-qqqGM\@s"3s)J${j; Œ+ttZ{tU5ke,{kVZGz]1at!y`-'zZE$*X_|\{8nqkCԯƌ͂7:ҔϵIvN#,ͱ&@9nqr_q;VD֪idccě,Uyꘛֳ;.,Ɲ_Sn6yG", lsE1ͨ Hڮy }j~a$D^3=3.39;q [qXϸN/#~BIF@9UutK}u?휘xz|@2FvaӦ\qw l4)e'^Vь9:}&8C جy;Fqv6x8un N@I\FpN4+I~F!in_pd+ VHq*Rݾho\u-eJF̏CZΨt # ,M\ҽ>p.tXv<0@s:ZZOKDw,PH8+CSN6.Y>;&3ϳ"l͸zqv5F;lin'cKN18c/kYtCtu]t\l҄[Gcy P5]7K:miSz:sR44\-&/(9CRQ>O:B}^C%EjtO6Kw(;Z !=(\?UQKhw|t8?0| ⨵Op*$>QJI?RQErqQEEQBEPQE!QEEQB