JFIFPhotoshop 3.08BIM@Dana-Farber team develops degrader platform, discovers first met720260806PSCIENMAGUAuthorcDana-Farber team develops degrader platform, discovers first metabolically activated molecular glue Science@https://scienmag.com/dana-farber-team-develops-degrader-platform© 2026 Sciencehttps://scienmag.com/Dana-Farber Cancer Institute researchers have developed a systematic platform for discovering molecular glue degraders, a class of drug-like compounds that can redirect the cell’s own protein-disposal machinery toward disease-associated proteins. The approach could substantially broaden the number of proteins that can be eliminated therapeutically, potentially opening new strategies for treating cancer and other diseases. The […]ScienceCanCancerCancerCancer Treatment StrategiesDana-Farber cancer research&disease-associated protein eliminationdrug discovery platformsE3 ligase recruitment&metabolically activated molecular gluemolecular glue degradersnovel therapeutic approachesprotein degradation therapiesprotein recycling mechanismstargeted protein degradationubiquitin-proteasome systemC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"4!1AQ"2aq#$3BRb1!1AaQq"#2 ?R:]-c]tAk^VԞ킴/W5'Z<8v AL!PwKƉkoAka"X{ңc!82M)K x&3q}tMl٣csG)JZ;QvZ_^+6 3#C_+qsKM8/mppQf.>9d.zPtf-V[Cn muYaRǦH[)-uok A_*gV\ߢ1S)g,ճ@Yhdkϸ2g#̜^BE0xh$vp' ve'V=0؉^\tp{$7N xŮV(XK2\3@ؔu$o^>$p &4SZdN5L󴠭DId-}׶>.+>fkosӛ鹏<*1t&!NW?O~jkHiCʃXh=-:=VoC799Ah}'gD|4Q{<٬674p :yrLv^ϩ3FVM\wo8 ]!Xw%zEj;`1/~Ār{Uq ȇ>n{k(ki.>* #iD~ױ|򈊵LDDDDDDDDD^MnxG$!Y:UX| ).%I wWhܳx[Rc'3wSygౚ}QwlZs֒>$,[tPp +~'.;慿0D".ǩ'DF/#Tuj3i￱VX5`*o$Vƍ$qRckd+As[A8+فBl l `vh*l63Eٺ:K ed:\ϑ?enʝvo( O=NeA-E> i߬űg, h׵~qfZ+0KL~z>˻hcd3[߯¨tM7[9'JӸjz柾4Yyq0Ӫ]aey C n.aAJΕKӧt7Dպ}໩=27Q4#SSZ~*1 F&lsG`(YWÜ52&|;E[W^C?Q+ḹl yA֖? Kb8rBW<ScqCQ/.%ߩڬS|fЂrPnXE&>FI= gAe9g bI(CqO°bi%zjw*6niӀ#j~ `[jJv\tz>doE/ Ha1r#>\|47By_-˒FIy\=66uط{y{\|Ẇ8i,ȟ`x\~5 `(`➎\ݼ\4GqD#?e p]vUDUB""""""rؙ:s>I7Q#) MJ.% _OF@mS?f\#H]^VSk1\FIzK)Z>H:WJ_7bDZ,.1$Lvѡ; j)nMUOii98'fj}NS![7D4x zTW+}"YsGnu1 URG͍ZrZWfc