JFIF Photoshop 3.08BIM@SNORD18B/SNORD18C-RPL23A Promotes Homologous Recombination Throu720260807PSCIENMAGUAuthoriSNORD18B/SNORD18C-RPL23A Promotes Homologous Recombination Through BRCA1 Translation in Colorectal Cancer Science@https://scienmag.com/snord18b-snord18c-rpl23a-promotes-homologou© 2026 Sciencehttps://scienmag.com/pColorectal cancer cells appear to have evolved an unexpected molecular partnership that helps them repair one of the most dangerous forms of DNA damage. A study published in Cell Death Discovery reports that two small nucleolar RNAs, SNORD18B and SNORD18C, work together with the ribosomal protein gene RPL23A to promote production of the DNA-repair protein […]ScienceMedMedicineMedicineBRCA1 translation regulation/colorectal cancer therapy resistance mechanisms-homologous recombination in colorectal cancer'molecular mechanisms of BRCA1 in cancer non-traditional roles of snoRNAs/regulation of homologous recombination pathways&ribosomal proteins in genome stability RNA-mediated DNA damage response&RNA-protein interactions in DNA repairRPL23A ribosomal protein role"small nucleolar RNAs in DNA repairSNORD18B and SNORD18C functionsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" S  !1AQ"a#2q$457tuBTb6CRSWcrs%3G-!1AQ"a#2B ?ݔi=_izQ\E ^*$9F%>ﭗJcZ2U`URA!o6'*:BB wU([m{\U $xmJO~@H9@I)87![+RsWHؼ[ށ" ^!$)UE>lWL'-I㊔V=6?&N]7ۯEaN]㺷+[Md-IG'=ha% q8˟_ \>2R\ t֐pHŵfu<8͊ÁdJ9q\7 XX >>Ap-"j3[;B%Cv'D3m׭:IXIZUp&GI<9@E Zs":vuHCm NҢJՃ'<Miԑ(H qҝ h6ܑxv+'䧀PvvtƲ^*\B Q#?$z>@OR@GۯF;Ob[Ki-m5M\: J2TUcݎ9jK,e}E9H"lfd8q) HXS qmjø=3{j3 wIϵLbN6;S ; j۹)Oy2FHelHa&YyP/P[ng=H32(36yjJ~P>rF3pE5z2ʋrZ<7w_-iJ#qJ$eyۨiԤ:O#թ ψ938w4vBU!pBJ9$xt>Q8 Z6rOjX~Ӓvo$$:fԨ!mǕRۙl7nݑ'Mi5?*hI]Xm,zHtƱgO-@#)~ӊlA!bAJAWvqw)=1<ksk1dˉ F?'dd?+J F?m{Ÿn!rf/d$(|xruĒ,NpA  >\Y|qI{]yLjV0O|&]! - mMp \jT (jC HPpFyfkƺǷǺ6( pݬ+8Pǟ#>U0<'AɣB QfbkMjBH>KO1{g)ސqV`<)+UYH^T ``H9"uP A856)@נ((Iֿn+W7PʔۜWSԄ%*H GZk;ܫ>;t_eםqȊp1@scVc%,t8IJ5tb d_ؼa)&Hm9RdRBI9IV|>jO.e9*2w(yߞ@@(]`+>OP=*;P)\aM`~sJQ1 I7 06yNib7%HNA:=5^vsz86RJ }`|PϤjv.:'Һ?jb鿹 /Y@Ŵw ' 3c9T38OQ5)ܒ66YuJjץWj 5u`43+'ܣ\$''α*$uD0ِ htnJIz}B$9. CsqM;̕]M}cRf38 g7oz@v&`G̸.2BHjMnҟI߃.ay qKu\,Ȏ8QAH<0\YZي(`5R4Ϥ_i$8.wȑ}ɠW(f}j.Ӭ meW#i+F*(fk"T_ZVq ?{$g?=nEoir ZkRD0Ya-*+v~Hra4}\j*USU{7~R.G:ү_rz*9%[CKujB>JIU /V%-9oMz⊎*M&&}RnIּۅh:;Fъ,*Z bv_/zZvRI^7C_;F!.7BSNN( WbZI+VԛO I]wNJiHlwXmJ;$I6hhT/K4~iJ yVM7Vn.m  5*Z -ԝ!źtrAEN8N2beq]V@ъ>BSë苤27w#&Z_ܔ9릭VXm9"[qԕ$VuS)*.7>+7Ѯ?StbҥJH4h zRew$+ryC 8t_sÅR fPR9'|]3 BJUq]X^)RW^)8d ҿU'lK/JVRܜci| ~W:zTJtjv:_ FwaJ LfUtfeuUW_3XJGS><{B< ]ZRIg񦵄EA4sn*?դ$չ?kVz +2Jy;٦m%hTE >jo~~TZm'SW-))Rl{(ӭqb0I;[3x ER~T)[R~ȋMDR~T eY0vSTR#v1ǢGu~ܶ?'֫6wOJv?-.72<)-$RRn3&{OSSi_'JI۰~`}!Ƌ+QzvY|h +J"*U