JFIFPhotoshop 3.08BIM@Engineered macrophages reprogram tumor microenvironments, boosti720260807PSCIENMAGUAuthorpEngineered macrophages reprogram tumor microenvironments, boosting antitumor immunity with IL-10–TLR9 switches Science@https://scienmag.com/engineered-macrophages-reprogram-tumor-micr© 2026 Sciencehttps://scienmag.com/Cancer immunotherapy has transformed treatment for some patients, yet many solid tumors remain protected by a hostile biological environment that suppresses immune attack. A study by Wang, Ahmad, Shui and colleagues, published in Experimental & Molecular Medicine, describes an engineered macrophage platform designed to overcome one of the most persistent barriers in the tumor microenvironment. […]ScienceCanCancerCancer"boosting antitumor immune responsecancer immunotherapyengineered macrophagesIL-10–TLR9 switch receptorimmune activation in cancerimmunosuppressive signalingmacrophage reprogrammingsynthetic immune cell therapiesTumor Immune Evasiontumor microenvironment!tumor microenvironment modulationtumor-associated macrophagesC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1AQ"a2q#R$3BS6r8!"1QA23aBRq#$4r ?݅gڟ7(((|5XݨžTZJۅj-nœURa/ΣmzTïhp xv p[Y7qŖpgRGss#v&6d]v怋H3BadMsU%A^z1[։=;`}kO+[hrmjGY\̴˷b4-9 DRfvT׶荕qj>1'NwOV<xc:;̚ mv > =mw'.Tk(nwHÜ_8QOxRgi5 yY޽~Ńo rd!fwF*V+Ԯg)ڭ?Zd)|Q;IRTVmiMZ#-6]E)#t]'{/pvk:!2pA/kyލ NWt޵Aհ3D*RWȤ58%H[J;N8Qu۵Q/mKEִeÈcWd66S]F*FXܼH5˸*cظ@N_0i˂K)۟~ա.$|lx.5cOQE6QoTQIkYú8́'NnJ+Rb:b4*MTRqDŘK@EV],Iiٺt-$K W_x\1/g|'%7O+#DHbuj'kiVԦY+^9%K<)6?T &bWA@‘.-& {V t K>ÁGj%? ;|P# \Fێ{BӨUs?} |2LTwI#.T:z:!Mc[g@YW@ rwopt&Yt6woF]eu1qfFkwu{ 使v֓Kؒo<;i|?볪]*D[(#.I$Q`Rܽ$'D :$-摕cA8q}c(SgbI KC9we ,_2(og .wwmx4ᯣvbpuGG1 4R7J]6LUL=[1SgXgVa&5h6z;{KTs$'V.W^|CdޓNk.ݕ@1 Pl`[] yQ@Ef's@rajڌ0ώHObwٸ=aHȬÆ/3xޘcIХگ*\;um1H{y56VeptR;1=S*ECL s HRv|T;ׇWhTp3q3d|Wh#U5.'JˮcTs<)oA`2)b׽> J@ >}C , ck`9 "-*F5^+[^|CyuRmV Ǎ Ľպcw?0$5^i07q|d1[Xn)n_E~[Yso$&}ti;wKlnbE.D?S Ϥa = ~'\Zb_akG QyI߶>u;gm~R5gEkIa Cn}'4bX%qnbGo#)Kxxʸs .35c?p\^+V;+^z{ H`| 7c3.$:&hc82Og bcٹ@yp u9#wvKiE,e[v/=JZ>@w 9|Tg ;?éML\xpwͣx~5;h-|<ۦ1ļMn'Y7\ h9qӇx͉9&v1wQ_#c' K^f?kUW{,ԠJGA$B9n;ޖ *Xo,n`6Y l^bކۘ˲TTWcTA5d2`v 17mB!6[y{z*um\hbß^5jG/bD0%mSG_>˜uIЉJI?\8(Z?Gg_ggns6SE&x ?Zm JP+2ocx^{t)WOxFх!!79}WC)iۄ=%"#U]A'Qz KDօϔY o=属Wgİv^'!PuR̫b[[I 'BE# Dx$W9MƐT\OuEn b*OU}u=_ZH+E U)^E&du;VDyF5Ca~qJ~>h wQsH(an i^Y&7 ?zee!mz P,Qw_4p2@ܓSclQэ7>J~5UHU+}[ފ[a/oKڔr|?H\+jevp(k79Kɑ Eb ?T%$-.U0ִ~ > Ö3^&Уb?IsDW{ o$}+\,#͢iNbִ4,Ē崏[~K-Ń ]Ο>jR:H/W&Jk[Y ֛^Jn&h^wDGm$8? l& VHa4(_'2/׷R8ܐ?Pl/&7 uG,Lyǵգ>Zb6QTZĹKc*Z7!}^_iftlTLs#돼vRyynwߊj$0d[^GX$7)kCͶm@kTlU7\rL6uMf!ia=#teRḜ$z E+"+茊'Wu@T\Ue5Urv%F@PL "Ny;0 0M]# ǡn0'lʿeb*Sﲐ} fl\/g^.w~ Kt6d$7pVٜ!|Vd8R[l/8;<)lv~qQpNa.N?hֵYXE i2;X*ڗxp3 /5-KO2=g]\89'~',R1*OOx=tK,cKi';n^©i&+QػFa=Q`[ŻڱǑe;;K;#ƨݢa lIӱZ_bݽۂZcY$KHۙ';4wqz󲰄 l*c(8#L|oA0RR:-dcn!;WuNǜeytow ᑒ13'y&FWɔwk`q : hEQO5}Cuyo`(֜һ.R!0t:d'~k޴k =+nCz4P)36N 䕏aKDjMVp9"2Gc{]I7wD07|#v:"5R{ guzeBFo{ b0,tTm5?CtDeR&0/ÿZk$sқ3O␇0_36+|U_ [cVLɥ|d JwOXT[JP]\E}CJߪپW'RգF?쵛JM ! (la#GSҍ s(-:z-@RVR(R#hJNޕ*PAV@G3vjTF\