JFIF8Photoshop 3.08BIMBTargeting 4EBP1/HSP90β/Nrf2 Sensitizes β-Catenin-Mutant Liver Ca720260807PSCIENMAGUAuthormTargeting 4EBP1/HSP90β/Nrf2 Sensitizes β-Catenin-Mutant Liver Cancer to mTOR Inhibitors Through Ferroptosis Science@https://scienmag.com/targeting-4ebp1-hsp90%ce%b2-nrf2-sensitizes© 2026 Sciencehttps://scienmag.com/Hepatocellular carcinoma, the most common primary cancer of the liver, may become more vulnerable to treatment through a molecular pathway that links mTOR signaling, stress-response proteins and ferroptosis, a form of cell death driven by iron-dependent lipid damage. In a study published in the Journal of Clinical and Translational Hepatology, researchers report that manipulating the […]ScienceCanCancerCancer"4EBP1 protein regulation in cancer(combination therapy with mTOR inhibitors)ferroptosis and iron-dependent cell death+hepatocellular carcinoma molecular pathways%HSP90β role in tumor stress responsemTOR signaling in liver cancer Nrf2 pathway in oxidative stress#role of ERK pathway in liver cancer sensitization of liver cancer to4stress-response proteins in hepatocellular carcinoma*targeting ferroptosis for cancer treatment$β-catenin mutations in liver cancerC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" J !1AQa"q#2&7BRrt34b$6FV1!1AQa"q#2R3 ?Z/jgz0{ }-IX# O+6|W`oՂI*8|\>|P+KSPʅ(B*vߢϷ;7)E̲[Zޔۭ2mP]ˑ-qan#H껍%ni) mQ \s*\Hy\N:ʔIzfl@mj@yY$8O,dK(#߲>u-5Vs\i4n|OKhZyB%З|1PHm<6VS% ԄV4IqGxׂb+4c_V =7Z[.-zSYmQ'p*RRv>uHBޏ1)~?v~5[XS8~a4QE'WJv}r=digyԶlzSiDjy\wo,n{n@XHܟ(>=VHpȼ;b y;T) }WnxMO,w/(ҩI=is'Y r'<9 hНW9e3Oiըu7i֓)|(jq= ;A7_IpҹLwU!Julx8].N3 ZV[RsxV6Y璼F=/LO5v׈k/!@ZAKa{q\)i!gSq<(>ӪgΙFne)Z_^z)G#5k Zɛ0]knYRǘ'’<8%O=i U$CqAmB.ZOŒ@df:[]CkHoNRӃ j3JO W‘w2:}gÆ(YˎحugM{O<êՌ#f$T0iL-#m[}X#9衑)昩y- C9 ̚h)Ԓ' S[ mL4QEB鯡;UR,?"-E q0*bq)gE )K*x}UnL8YL6PG"G<|8i^¶m$olr7yJ[8 EmQY. OFkMeߥ/,)M!KB՜IM\.Ў>fjiˢ爢aM xDRO{Ĭߝ,v*;*[LR$/ҚTIVLy )VHui:|0^AR+Jpu%'Mc[%O?bm-m8GM+ES!€r uυu K]:4ll`67?I˾cM,\[GE\1I7:>~I^|_/)Mb9ǕWKG^VC-Д!%)Hrϥ#ƅ{8AgaV0Ie>[6,T:MV >q}R[dXʜ[JS|*sN:sTiR /'@;d\5h3jS<ʕ8Hg$';58`)3 X{;|ZiJ (=FƠmwy! c0ߟHy;D$$~{kB=+ގ"w7#` oizJo=06'gnB;n)H&:ϝQD&Nzy8K ${B5 ۪XRC, IڟWR@}qd,Mhy.kܬhm}폳K,J&Q䃁 }G"]T}*e)y}Y ̏[j=*1P +yI*ybe&<+5d #Q>>>T뛌i  j'ωV74g ,iT'xv*sUl`L,[W"`id{]3qF@m0KhTQE!F=/LO5yz^0;_y@zqϖƬ9-%5) ]G `S ø”E- ئ;KMe+M|V&~TԘQxu*>d&ҙ~\<2(+Bm4~ӎMRI&_ jR6e6zi HxҀx³rU%hu'CI c*L Jܝ-1'?]L۷il5}*#9,5Α RH{F#$`9ˏ?FA;!B+PB_RA +P_ uT27C,wgY}l4ݠq(dSXߠM%RsE>ull2KLs*V*:tz\(7?RetK)\.*wmp]ɦ\庒nl̤!h$+ HW6|/XBac[ ~F U3U^%@$rH<&mKA}6;Td:!G>X8S H)>k :6) ' >E=$֞,MʱuQQmNMZ!R[ @D~"@YNնEʺ~y*ƳFkh kM^\vۗT5Pbb `) mH;n)kW Qq 1–o3ƀ7I9] Cb e\e{9>Uit.-vثΚ>j%&ST!VHxWʑ{l ܚ(nR.lYr2fz3_>@.jIq<~Il0On}&Y{* 09;oF~tNa<`}Y^yn:$n$>xS7z)%-+Kn|AW#&Nak%-K!Mp(W9( w*kwK4$^\J0B[Xq=Rd\\kNy,>6VM t7#mZC׉FH GJRӑN!KKXL(xspyX>s[iW6!<6cp9gΪ5z>F/_T2;V1GIj~ż[^K>GO#TJkLj1h.]DKqYlN3:^'U/ޗsFOpsY%}WVIrr7 ҥw \Ϛ,l6ZW3=knvZ$'7 wm7V@>QYj@ 8)>Up!Ï+QbXe `+mn 6>5ś[x,Eï|Omu軠g). Il(ryGs4E!QEEQBTcWǦ#Ƅ.%[ZV%YFS0whxm^YQ8IAY;cw{Pܝ WHBp3z}).C?ek"NȰ#}o|hćYM+ex84SXNQ\d(("(MNݵ2lɏPDT8 dh(кL(~lXk+кSlXkEj>O5<͋-~ u5hRh])6,ȵkѡtŏ T T+m3d k^G:j_)P65h