JFIFPhotoshop 3.08BIMACalreticulin-targeted L-asparaginase–flagellin conjugate boosts720260809PSCIENMAGUAuthorhCalreticulin-targeted L-asparaginase–flagellin conjugate boosts Salmonella’s antitumor effectiveness Science@https://scienmag.com/calreticulin-targeted-l-asparaginase-flagel© 2026 Sciencehttps://scienmag.com/Cancer researchers have reported a new strategy that combines bacterial tumor targeting, nutrient deprivation and immune stimulation in a single therapeutic design. The approach uses an engineered conjugate built from L-asparaginase and flagellin, linked to a system that directs the treatment toward calreticulin-bearing cancer cells. In experiments involving Salmonella-mediated tumor therapy, the conjugate enhanced antitumor […]ScienceMedMedicineMedicinebacterial cancer targetingbacterial vectors in oncology&calreticulin-targeted cancer treatmentcancer immunotherapyengineered bacterial conjugates#enhancing antitumor immune responseimmune stimulation in cancer$L-asparaginase–flagellin conjugatenutrient deprivation therapy!Salmonella-mediated tumor therapysolid tumor microenvironmenttumor-specific drug deliveryC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1"AQa2q#$R5B1!1AQq"2a#43BS ?u۶Y) +~ftLTYX]'-5&82z֕c OcE`-Ǎ 2ÍNV\Q+dF".h{w c tK.H%{;N^2m𛿵e"D]_jllS"MğrnI^H85к]Ii ȸ{Q{r"bU:yeOvMJG2сZȢaڌz-tSW?vh&$1^I<0DÝKQtoKPXiX R22"&W^ـq{Ii, V~36(=L0WWl61Z)s9zoqaa#Mi[mFi+>keś Ttv8DRgPsdlL}i&~aԷoS/]G1\lS G#d0Ltآ?ޭ=%Eֲtu3Նwgh囤2Lz'-{MjKNE\Z.@4y*NW4Rс*C|7w67㚀-agG( FNL+{WZ 0na6BT"h)@rI!n>RFto,f;Si@|9SxhzcmPET,uhoPyZAZ4Swx >4XiZ~4R}WMx@ bAi= I Cm<ƶZM-O7SΛ6g/e7wIprFp) pfƟZ,'P x|;+OM32ZC N3;֭KEqfoO3#YG4;%CQxR7څOfHQbX( `r)_簹vbr<s[13?jn巹X<`5"gxLKZsqpO+;{C{6flm"Le+tGUEkm;<$`Yu8u_|39J>=&_b=?]N면HWf.c  V_ҶXtY EMޚ*_VĬ sP.+2F:A+hJJ;Trӷ5zU2jC&I$r[ߚK-+SgMHvQȮ$`c>%{|D-ퟨmg'a擓Bp1zZ~ \yXaZOcE:~'g^O6A,ZG pkf{{X2H = 5j};iYèVrd>H#j}9ZZ[TGoS#ԯcg!SPp?曎#Gݫr"{Y om),6}WN U1M8cO=-efmBځΠf1S!ƚ^aZ;},WPޠ>E5]*#QO~ÑIf#`?"\Ǒm+$PT5NL3Q ?ȀĩZjȌtߤ9<~ c C#ln|6te=iKtun%xR@]=#j"Hn$=:OL73_jƙ#{QMXgmj'f8:OYFNf,l-e;OݵvA7=@8ah(?|4fHfxnNF޺WDzR ̤ ,m5lrEÝ,:T4kXѿ:{# Hy-M^Y[qEzңևBjU*mW^1`\Iݥ~r|qrJ&O}+=YQ[^ eDLiMqexU0eXN5]*5DSjE&aΑ/o;iX2"k>3.C,QQpVG+ԍ !KJ*GSc4b{hdaʉ{>-Y޲; $9Yߡ\[Iqi40>ʷ([-xAPavw?RQM0y1 l{=闬ӬO-,[)(rL OcU!V Pj$absBd ;mʲ4pMkwlȰ2YK*5nѝ#!|H,zD-ݸǘ^RAn ;OuDw8,&}zGdtEd@<~ 䅂9Ay}¥Q `Dchvib:`Pۚ14D"3A 9{ qֳ̤T N@,N`%^Jp}kƥmiiwod]e-EQ<'$Ѥv@&sEy4pPˋn3MLM-jr4D*)z@&޶ ǚx&ki0|WѺCFIGG Ltڲ5,j-% 4