JFIFLPhotoshop 3.08BIM0@Aged granulosa cell-derived iPSCs show impaired germ-cell differ720260813PSCIENMAGUAuthormAged granulosa cell-derived iPSCs show impaired germ-cell differentiation; ERK/MAPK inhibition partly rescues Science@https://scienmag.com/aged-granulosa-cell-derived-ipscs-show-impa© 2026 Sciencehttps://scienmag.com/Granulosa cells, the ovarian support cells that nurture developing oocytes, may retain a molecular memory of reproductive ageing even after being chemically reprogrammed into induced pluripotent stem cells, according to a new study published in Science China Life Sciences. The research shows that cells taken from reproductively aged mice can be converted into chemically induced […]ScienceBioBiologyBiology*age-related decline in germ cell formationERK/MAPK pathway inhibition$germ-cell differentiation impairment5granulosa cell-derived induced pluripotent stem cells+granulosa cells in ovarian follicle support0improving germ cell generation from older donors"ovarian support cell reprogrammingpluripotency in aged stem cells1primordial germ cell-like differentiation failure$reproductive ageing molecular memory#reprogramming of aged somatic cells/signaling pathway role in germ cell developmentC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" W  !1AQ"aq2B#7su$346RVWrt%&CDGUbv2!1AQaq"243Bb ?ҷ/h036~ZꬁzßC{Q2)T@tAJ) TSݫ_DnHym%7>*ں,35˔Hpj˿P7:"\1-$$)$w}1XRW.g vqT]r,4$WkRQHsx^yt֦Giwkڤl}.XRe(x 84WFiimjh]0}Qp`(>Gʄڶׯ86 ȷ9:XIhsAJ1R|j-۔J}8I'$p+I+m㦛\q"؂HVFpr(LJ\xR8ixo "Ndu>ŊN<!'vsʀu|bz,꨷+6n3J9`ՑXSEvI%/) Vv`x߸vjRu$Y_~$6͐@GD0@vs>_7 v`T%XH5ĶYNB R4oMLmO? VBur<( "~*URI WURJrD:YǏuDvϊ4RrkG}ՙxpSQ !ѱ-%q>}yqU˖Iay 7-d%#tqFjr=fy|mSؓGG8‚ROiZ{!YPa펜&j@1R'<9{ktxq> ǑwvM-P+ H􀶊T54)h C$˷kSa_NTλ R[Jk_D: ּ.r츧>JlUSjTdyiIϸxZ?Է7KIW5i]2ͱO%r\q q'bSϠtbTF҂v'>5Lg D:(l^ޅǍV;Vq-nH /_=՞5i%6 2Oj1[QF-QVEN$yG'>~څ sᩛ>FKrAx7m{ &+?/K=6'Eoz&PUCe+[j[0FYG?Ah"TDRTHRJOB1T'i5 L:U::I_gլh1঵At+) x)'GlҚ ˎM |Aj'swGrA ϋnH \4Vq;_ x$r﮼Aw5OpHytn/ KA0}¤j;6巐**Hu)djALRGM@??+w55$=;aJqnKa!i8'_)-qfu.&R]2ɨ߶\/ ]ԝ%3̌ՙq>S*Qhv 4nWW:Ph $.RUGrE-b2"I8B=3FMvZ!E'#s~=r%7[4.ߒCMQ+ xEWpᝉ+ICi$!=XQGADžX^ۖ+SLQ[sH^OFtMK`nuum`sG*sj*_ *'++Ϫa`ʭ5g`MMފᔝP JT{)TPq}"Kg?+,ʐ^)\g5+dbݓAԅw`h>\$&i 5Ar&[ :JQ(Bs=zaiO*F-7+i~F{) yӮ9##?X??GU>^hO~#/`NR?Wj6e&%SАziN.\oI0t͹[zZG|Cônۥzb&#aŰ':IPKy =qYML3cNv(u&H|J?\;'J}\W?d?;j_ J^|֜~JS*~Nv.n#t EҢ|'CZҜi!mWՃSx^n".R` RT@MhNƖ ,9aR7 >R ϥJWY˻ʑ!p9=9Jj9Vh*\5}iORz8\ Mr+-zJj]܅A#T8݊ދJ'TqeAϴݭ"C2`+W^R’zS-JR9$mbGRڙz4gls #zU% InJ{{$,593nŻI CaM5;TߊA6@DtpE\dZAԾx) Yh~mN9YVԇ6@ u[@2ۋC#֨oK )HyGigN44a>"9y)B:]HRI$|IʟǩiVT=OM,ZZ{a>r 7$%Sy'{UR0 O9@>[q98Oя;>IQ+Lc賨\&aֻがlM;A%.pʹ˸"%b!T$6+ڊ|Jpvqx={<*$#|+pƽ^}ӳa*t ) $򫷱|gΪ f &9TC-8Cg8}m1*KA5^mTTթ)!I)ʯ5k61Bw3죙@lmDn;-KjD%^n{Ԯqf+?d|@'1M  ~zg?N`먖~|%#JR28| =7&de7ZJ~~ZSBF-i㝺d nۭ.L >ۇvFrJs(V 52\A eMpHUhJˮ4;+.>L$rzP^u_iY]o9?x.fniX!V݅$ӧEP5.-b;[鹶Dzּ%6#)9Fz&ܟ-*! Z9S?N mvRV<v2WVXE B^H#ױ!֒wH Ιkpх:I^^ڞ떘0U>lUYզTmׅu[QQ&n_eY_rvoFm.l}HX Js端%}|eSBonM-J*P5Khgn7[+_Iea*VzQS]ʇgp>rZ})cIa=]FTP$'U 5'B8cOi-uTmA22)2_SB⋪ P*%@$&x2A-@mlsT v*@}CgEr+>Nq>:[c%K^|d}ŴCP9̶ dZ-u&,~i= ǽy{tN ?&Sm7)̒~0cxfpkLOx-ig ^YT7 P\6BNpkz Zl-ޫhN}nc5lm2/ HVPAm3Whm pkN(uT뢮.[2Ҭ$vy0'ɊmN A/2\%:0S TGx`6gyqPf*#jv3cT>R-ry\# xZNnot*t1`[Y5ƴ~gNHD%e(ܤ$r@r<|++[I0*T/pG\V{ze̹*IX%X,I)H z~..)JOJ|<–R<]+PP'|Yy8̡ɛ)]n[J {(PPic(<|QRKoYN-yQܡ+6$gDQmit8o)mxJBw&BQJS.&T'O@ y}nAsu/WHX80ڜt nVvPƋkZyЗZ%: #9uL"cxMOm@7)Ë[ߟ9U+[T^yxS# c^LY8uƘƙ::+o){شR^);RscPݤtm79Ѣ<3㹗r=o0߫꩞?a#~=r bf4[^}U'9:#Rm#vpدje)Cu4dQbL4sXu\JawF^p9~ÚCSG:zFm2JR96yq;چZV493ԝл%1T1Һ'bԂX*  }"QK{l4,s:j4#~ pSr6Od?N0j</)#Nt9*iLX~ A5APP)$+`⺦CΟ4Q9qW~?'D^8C)OM*UDk?7MD Zm2w+d8WJ٧?{88 jW1?-S )RA