JFIFPhotoshop 3.08BIMCMonocyte-derived IL-1β/p65/KRT7/ILK pathway drives epithelial–me720260815PSCIENMAGUAuthorlMonocyte-derived IL-1β/p65/KRT7/ILK pathway drives epithelial–mesenchymal transition in colorectal cancer Science@https://scienmag.com/monocyte-derived-il-1%ce%b2-p65-krt7-ilk-pa© 2026 Sciencehttps://scienmag.com/Colorectal cancer is increasingly understood not only as a disease of malignant epithelial cells, but also as a disorder shaped by the immune and inflammatory environment surrounding a tumor. A study published in Genes & Diseases has identified a signaling circuit through which monocyte-derived interleukin-1β, or IL-1β, may help colorectal tumors grow, invade neighboring tissue, […]ScienceCanCancerCancercancer metastasis to liverColorectal cancer"cytokine-driven cancer progression'epithelial-mesenchymal transition (EMT)'immune cell influence on tumor invasion&immune-inflammatory tumor interactions+inflammatory cytokines in colorectal cancer3molecular pathways in colorectal cancer progression!monocyte-derived IL-1β signalingp65–KRT7–ILK pathway(tumor invasion and metastasis mechanismstumor microenvironmentC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1Q"Aa2q#BR3b6!1AQaq"2R#34Cb ?ytQ"' ϰG ZV8ef\>koI^BU"徣A kfH71#(Tb=ST-C$@*#DDO|bO{xreֆR;Ɩ\qŀF1Y/27H5a@?s= BNB>Լ˕=7ܡ;-+mL{3^@@7QEVaJ(H9ZRIPJㆉLTHtpqA"՞J(j#W?Z+I-ZMwǫoq+.WTa Sy7 #1}F}BG_9۩_H]afFrVR!¯%i;Sh9+,g ֆkdovS "8|WM䷹9l0sxFm*[Y2=̍F,T7w>*7J$23 /!9TnÃU†5'=DоFyJ(QE$RASeI sHRuj*y&9l{-SC+5Px.4Qj)+j1ҬkՈާ4T Х|kRf }+aUn [뤂IhO8L>@Ig]\*c|0r8]}nXq r3޳-kQl ?Jw:]w(|y`8Z>'J JCWP Zi`#I ~WԄD'P"&kCvcj$q&F 6>? (PlM#R,#bXsQ$(-PZH|HUz,08Uj2@(?nZ]+t)DPެBA⹌<.V`%Y*t;mGIpּ̭BP:t;WHoaX9Q]U,p(6=ʠRTf* 5R^{fn4/'Vm'ETyYjE+qdY±s(6 GbwIfがzLK$/l$3s;dlXj^U3d1Fct4Y_*QU?\?~U=M4oҞcO$bVi m]F,XhIOR7WSS{S;G9f6*~7A )tKpebBȼ{:k d `GP4ƞ@sǾ>i돬6Dli:%~cjWӢFoJkڕԗ3csQGj˩395й?ƃ@nI_#,:ℌN[A"'B4O04J~2Cڴ8n7o.ykl_^]i:|,$UkwL|b/"ec7QaakS`uX[kԯo/3?s\2GդWoRB>>ko(Wj×Sr3wE6=^Zs{Q3<ޗ>o4.6p{*0Ē}jeH9Y8 S##CGT|'` C{Z*>h}Ovʪ()ERIlRnU,3:'fbLjr皍uAcSY, .8 Q Qڝ=Fp4Lqa5ܹ _wzk Z )'!y=>_[{HRzc,<#>v> Q{$ >v {=+\x5QfohS[jx?y}g\EVHm[ m$,!nЎ}~B9-$[- Qi!ysn/]؋hAڝm eSzʐbkRSko0F>ځq(Ƈ5buLͦ6-FKPZu!$$Tos袊ȧ((I"p {H8a~s[X+ jO,A}GUj,AպZRHu?G!{t|/k{ߔOZW]$2ػ_k5ymeKbnoKup8C2z㰯@Y'^_bN˲L5i %C7G ̮h=ɵm7=ZOg[ߣ=s q+I,k>$d^ջiԂB0w'q+Ļ\_I+ϳ),O pҧ>yoc^†U׆;q;5uO(x+̒5NhO)'W$Q&%c}'JFfܪ.7(Ef\JES((N)t/%AN[&IbF*S:M^GX暜kwQ%K{ fcu#Qvo FSPZ!8]jlb̍{-'zJabcr=jөł:b,! Ak7()Ĵhve +⑚C7<4v3\̑zifb@y?†ψYU}O R,~MhZ[QÌ.6>u^ LQ+d\܍4?fuw)wTN=PjD`9䓪`\(⺖+0EQI$Tz("e>a$tc~Ɗ+wC5 ~e ]/=i4fWbaEQ)wVJa]OEbKM7|ērryrN/ThR?MF+EQP