JFIFPhotoshop 3.08BIM@PARP1 Drives Neuropathic Pain Through GPX4-Dependent Ferroptosis720260815PSCIENMAGUAuthordPARP1 Drives Neuropathic Pain Through GPX4-Dependent Ferroptosis in Injured Mice’s Sensory Neurons Science@https://scienmag.com/parp1-drives-neuropathic-pain-through-gpx4-© 2026 Sciencehttps://scienmag.com/^A molecular switch best known for helping cells respond to DNA damage may also be driving the burning, electric and persistent pain that follows nerve injury, according to a new study in nerve-injured mice. Researchers led by Y. Guo, L. Huang and Y. Chen report that poly(ADP-ribose) polymerase 1, or PARP1, contributes to neuropathic pain […]ScienceMedMedicineMedicine!chronic pain molecular mechanisms"DNA damage signaling in neuropathyferroptosis and pain signalingferroptosis in sensory neuronsGPX4-dependent cell death iron-dependent neurodegeneration"molecular pathways of chronic pain&molecular targets for neuropathic painnerve damage-induced cell death(nerve injury and biochemical environmentneuropathic pain mechanismsPARP1 role in nerve injuryC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$":!1AQ"aq2R#B$SbrCT3!1AQaq"23B#4 ?mCu[\ڐKzh6YsO37<(8eԊ& cNnPM ªqS/.42tEW$FqPh0L9vdڶk[4l19;4!Lg5Rzi6Z|ד& xkCi{IR"#cW{jpDŽn6}b~kZw9;7ϯ,X5o񰘑) pòk%$ e2Mq@%Fƥ315`ęN *5kuE&g֊>MΣqr8Y9"Z_o>xF}} e"URpO&l^HP#"k"NBH)=qK{iXN}Re\aCI0ɞ+e6^y%# ;qc>:1 P8<ړfG 3MfPxհA4Y65-;^o1WYu8%%ֵ/2/Ìu~X4͕b ?]knfLsxx]iDj" 7nԮI SԲ)cR؜T՘ܡ gKyV4f8) ˰OV{U>K}VbU2'k\Krslw s;;UH ʾ3Cҧq\٦% c!F$XeE ǾJ3p HrNG"{}*5"*7.0vE 2/*qEGt-Uǝ"kU@JZp0²;l$cngNtkhH3o;l9=,Ė95e "RH @?-[DUSg)<3{؏)I4hՆR=)x"ԗb#}0Ѵ;ᝰ[H+j&TH^|5|;i#1WJwBA$L-]I{p"Ku8k~,p"YfNµ[B|y~c} 49cAi/~nrV,YEQ ZMrH6ls=P1B#rVCfjѧ^mdDX+Sڝ5RĹU8Tr6ZCSCyp1#*W ;hi=3YL ؒw,G3U*8&R[y#ڡ%N V7_"3tIFNY#&u6PUm;H}[xjLǠJ˻sb}Y #P,jSq:-0m($39 T 0) e)'4*Wq75Y6ue=sr=/,-~ݡ„`NzA[J\v\jA\5#I*kQD9oY.9D,@H/)W沯dR>`2+:lm΅Yyw.L%^. 8je0,wqEp)=*jAMeEiE8u;qaP3z]3E{kvoUM\m, ?ݻU("رg[pܓ->,key_9jkɚ$PxE)x n ;Is[`D08c)DYسؚ\`e!A{+bێM.w&;*!q@9 E8rwqpv7~D Oh[y! :<#Z;o¸Y?b<:efQ<9ܲ䏭g$XEXbV>_4Eopsht<^`2gjq79=M|Gã`r;~K& (#+79df M+}E^ƋnoD$MĈ^nH4,ܼSE'&%ʌ߯{1iMseq-p#qppv^z(Z YVGʡgqsNq6]5꼽ʹ̲78KŬ9gd״Kh%4W9!]_J̌y,õ=4[3X#uOOּo?(ˠ*qxO$GzW:,K8U0N9K[[;s/zk.,4J+k:T֓$FcXi>izZm+F #8?8CÃXXc5dpgtoڗGkY0ҷ8Y-uR<'EQR[#9GD<[o"`(SVQ8kٕ2pyt6KCy{ 3nvomm a `3jWS@?p C("M.w|moji)*L)mK4j( V4lbdV#E}5..-fIc%F8a!eуEoea]y>,FvX^ݪ,Z˄8ۑ: m'mI/Q㫫9#hOH8T .jƞ/e# `:ҽcSOSd1\p:h t@mFI')해g PCVKmm%nUf"GZݚzx8w}]({M 1\;rDfX a&jk92꾢=̑8 8 YCƻ$[,ImЄTbӅ N~q<]iW S_YmU|72!(-ۃLKXfQX  ' SQ ~hs3Eekn!2t2{n'^N ݨrmuF;Ű8]j䚊 :BwSa<,G]Es(WF:znsb1OOJo3`[5~G4-v+\ېaB{$fHGO$NNS;opT (PQ\u@Vv@8mIlBsGְWJU\P;l.<޵Z#E5Djnv赞k..iNKlGLv/-I$ Ú[g1E|0pU%QETE4/Q[nXxd(A3x{SmKI\Cr[poϕc "y94Ưa%x%sI[w+"AV8X0Td)xQU74QI:.h4QEˑSE˔(HZc 3X袪͕((Ȣ+&Z?i0 .3sʊ)>-?N^^(*