JFIFPhotoshop 3.08BIM@Engineered macrophages programmed to target bacteria combat infe720260817PSCIENMAGUAuthorcEngineered macrophages programmed to target bacteria combat infections in immunosuppressed patients Science@https://scienmag.com/engineered-macrophages-programmed-to-target© 2026 Sciencehttps://scienmag.com/Severe bacterial infections can overwhelm the immune system even when effective antibiotics are available. In advanced disease, macrophages—the immune cells responsible for detecting, engulfing and destroying invading microbes—may enter a hypofunctional state. Their ability to recognize pathogens, attach to them and coordinate with other immune cells becomes impaired, allowing bacteria to persist while inflammation continues […]ScienceTecTechnology and EngineeringTechnology and Engineeringbacterial infection targetingbacterial pathogen recognition/bacteriophage-derived receptor-binding proteinsengineered macrophageshypofunctional macrophagesimmune cell remodelingimmunosuppressed patientsimmunotherapy for infections"intracellular antibiotics deliverymembrane-fusogenic liposomesprogrammable immune cellstargeted bacterial clearanceC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"<!1A"Q2aqB#$3CRb4D0!1A"Qa23#qR ?>{v֖iN 4~Ue%*T#`ǽ]gBjmO}pq,)Tz[<})lSJ/=.!);3[^f_.Lf|CRS(>|y}&!_-KRS(ϑ<Ө_w[„t`x~FLLtPX="By%}S?,QvVH >qHVb4aM!÷UO# 5^dqU_)s`>kykKjˮrLP1NFjxzZzv:6!SJBĝۀ()IF=l%(xVWum$-?7Vus#MhFƩZmi[KJ*QpѨ-KBeCIOMkZ`!I%}4nv/$ɺ":K_JMwJlCM%I*3 ސ.GO\M7O5i,PP?+gg3>l;ZO)X\foS61߸lvtk=vOC.3([?f(պ{ێ!A+wk.Ć%̫C-DMPÈ@HNsf:Vk.^VCqRyJEx~R MwN6. n_yuބg8EqoYe'uka_qoTJ4UWf!"绨Y;$ ;U l1&ʳo^%Nj\?SqSbWrq*׫"m/;)IJvūGފlh1HZA%؅%kTZu,(*OnaXRb2Qf*Vt[y)9SZGYO!FcD!kcl~-i'pI Isef'ùGqcROU58SIJvG<XX_UCY=7?YZZf?%b0\'ўmż KFI>rI D5}ibRq D۰T<~8%5W|팉BpSgU">YpX8,8 Yj{rGXtUÒ*.ceDx3O`%vrRsLH B7f\3ݍv3u-%RA V I)Kթ ?uܗ)\pT=1-!*S%uIp? LC6*GTvۼ9'8F,PY }Ǿl<ON|7uSD=^n+#s+?j="t6(|OeN`(<~ԳmSV8Av=l5Rv W`sVt= Tjd䂕$`)Ţ[NxQ?˵ِGAC+QRT>ޝ|VPib0.F:(JH+:? i.ɸf˻p WK۪e!>NsD34ۉqӄI#RTHF0FսrV>rv=)ewҜV陵Ǹ7d[yiL/Nu3UWXZ҇ + 0Z[POc4=29?ᨐf_-棱Wuӳ݁qLg^(^`P'qޛ #PWFF@Oߥw)S' F12ay%g>}B["Y̫ztS.K~qAZ^OOۂ;Ӭ5nGXa*(YQ>JtlǢ*Q=eYm^NnVyxUWy*rc:|!XvrT<Eg_[-uRry `koP 35qGb.q҉LI2uh`OxHT-Da{OvL O z~:?aG\TZZw%$8K3o!mN9E_Hiuk3lLc=? j[JmmfmJմUzuDk 3Kأr[#ϵ&+WKfzS{R t2AK-*= W`+nd\a! 4VFY,z2܆$C%Fq)GT;(&'&*ܶ|U%ɋA@IR,ؘR#8!j})%$5AQ+qsW&RGO Ywdm:XuY}O9I=ֲnquw%#nI,E_Ri;<5eH-a8*KLe)N[S~pr 2ԀICcoǰ!.=5x~Q?rܯ3(rg};Gl{曯}旄UI}rIz%k>zx3AoPEn $ƘU[$i`ٛfԢ/aAH0^6t  jjFrTMV 7*f*J( !?Oa⟴b%ܓ+|Hݖ[RrYˉ^;&ZKka^3YZ?ǯw~9h2-GZDK%A;Gw=X4vK-η+VG=y U.,Ȝ\mBV[lg*$C5jYHZ?p} 󤔫<{sOܫ)jGĖ︂֗S~U(K[g!AC#O)I&2LO8p)X4U \:ڮ"}ME_= hvCWIkQbmm ȄcT)oK\``ZNJρCZlw]͓rXuRjّBj )\v>3[.y vc Kާ ʢw;rPf҇"9J&crcVmn&'>O:,Ό(3R1Q4L"--Ɛ ӏzDѦcc^%- gL:hI|OPj VLKʷ+=ܲ/ ΃_Z:dSXajRq>%lVmYRAѭE7L5iRrJNkBӱie[w#h,l͔"llɽ- D[_tXqQIBCҺY+‡o ӷgہ)ug_ h{)ĀpاnkWY):Xϲ*RQ}jc 6պ}G P=8H@mG"*qM_eQ!Ri0⚵ڗk)'XHm6ziO4pE )\m vsTLzprvmg8Ld?4unHz ~}͈4A~VeؐTLt+dI>gRimP.ld8୾iGFd2I-hY@m*pE++Þ-6/] <k[ 7팧EeEvJ'ӳթ2liR|֕Ln>B!Xp(a8%I$ +JT Mlz't)Ĭ9x85/v3UgY~zBRI5( HDVGH姜xM~/o3U=esC VUI75 K!5}wKNԦNMXp#>d㪧=1}2 GNuBԂxN8ۚ6u҅mTV]nBI,ReWYR |\7(=R]o=dv| Yp־IgowOhzxۤ09c"]\{ ]B Gn1@gҧ1ZYs(CQ')5q 6MO# vD3(GS򏱦#te1x^2sH b~aR/M8ӂB }4J#3OB+#,{d[r[f:JLʛM8ڧHy)j!rqT~'\C*J[pkր˙%Fd0 FIgwڪ!ƛ\JBOoj6ţ"jD߈0R$)}OG~c`+R>zJzV]$v*y.)RFOڭUƿШs-2߱C뽶UeqdRa[iNv`(`sWVB!d%x5wJ1ΚbɜwdIO+Z08R˫#gM ,r9O2Be8c&Ir~횫y<ʗmaa Wei:A'ڛN&; 4Yƒz~Xv#P(Vt“k^;GJ[O%+ OiS",~jB$;5E5u9xuc$iu=-Ѵ~(1I:qڹI3MZ6r `]rtpzl6OW eRQ(,4€R;bpR 8)>kضJF(M#J;Y=zb%eĒSc~ːsJOL0+TC%,>根o(Z0+R}eKQTqDf IJ,AlN %8Qt>\N+kj9$gxIRA8 :Al(<jHӒ"0d6RQ9^sjU*8 ᦡ~#W׽ D*$lMJ|3~űjԷ8q;R2Do?oRϗ3giG$jjT'I3i9ӄN*TuZfu2qJ|S>y}5^7j*◿%4=5*TY!oy7i؄cG*Uu DNPb_TLuO[FOoj*R