JFIFPhotoshop 3.08BIM@Molecular Self-Assembly Enables High-Throughput DNA Fragment Syn720260819PSCIENMAGUAuthorhMolecular Self-Assembly Enables High-Throughput DNA Fragment Synthesis from Overlapping Oligonucleotides Science@https://scienmag.com/molecular-self-assembly-enables-high-throug© 2026 Sciencehttps://scienmag.com/DNA synthesis has become one of synthetic biology’s most powerful enabling technologies—and one of its most persistent bottlenecks. Although researchers can now design entire pathways, genomes and enzyme libraries on computers, converting those digital instructions into accurate physical DNA remains costly, technically demanding and difficult to scale. A study published in Nature Biotechnology introduces a […]ScienceMedMedicineMedicinechimeric product preventionDNA assembly accuracyDNA fragment synthesis DNA synthesisgene construction techniqueshigh-throughput DNA synthesis MASIC methodmolecular self-assemblyoligonucleotide pool assembly overlapping DNA oligonucleotidesscalable DNA manufacturingsynthetic biologyC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"9!1A"Qa2q#R34B$bt3!1A"Qa23qR4B ? $ M$+jiVF OJcͅ$^TǞJRy.EIfVڲ+=Y4FPnpKEUj3] iBdXHTiI]Z{MleV~[/WZuۓ O޵#Y:izdf93GkGEGuZՇKInuHT"+Y4 ,̏6{$\x3bJE$y1c5F3tNG`9jS,\fBNP}ܹpԋ d}bnPN'oni1LQGRJX&BF{Ѐظ;e8'VD/>PmJu:MnߺeKDN Ʃ_7\ۭ-r-rc4P3g4tIk'jN +`{cn7X-}XKG=VJ>f)ܾr&M"iӚ8:5Z)Z/E5dKvmS%k#Щ.SQiG 6Q !ۜmCkl[YRTV:0r:>-wOzT#5e,y>$u&O]KiX7߃}ji ]B\`8zRڤ'jIis4jbs 6P_2E*"ث|x:{htӆ7e^w+pԘ<}\C%V{SA@tX|Nmn !psE:zSyY&*ip`5~Jx^aczM 88)VXۥj>aҤ#?Ǜh7t@@Nʫ#չUFP dҀ"巀kef" ?tf==ǵW[ BJz2Ml Jˑ9i8yl!2Q%Dx>Urud q$ڴj8.d Di2QUӖI4z7hϒ[B7$㨠W"-o6OZeG}Yw A~js=#w|Uo VTC&vU'C9f@`9|;v %=<Z\{It)rq RNJJ˴U˾ יv''gQMXv$KCeD+MHH..c[qRM:]QehpYi.V {Q@ַ-Gw?ҟcM4I/(Zp]ɶJR;'=zPjiT(o)rjvTqg$N= ;&5t+w";(2^}!9YZbVn2aZZt},(#Q֛[ASB\W?Σ|3j'^ܱ 0JOwDSG E/O0f{+BʀYqwJp{}=\ScvrZw‰֢[8>;V_!ԷϹOܱiSL랟%0T7DuM3{}Aœ-4ҙcuoucLN(d` H_fm  `{$yjS1yq;ХP/߷!# G(hfl8 fs{ܯ <PPnՑS؟֎fbJw*ASuZxUim1X] s+ #w{{b 8FBRISrUML:R@eA[1{*H"a mTm3.-)t 0y uQGkbhnv8:ԨH)Nހn:T6;QCNŷv7UU if> RN@WoepO;Wnz8Nmv ߂h.D3ڂ|m.6/9s_u $jVYz[< ?o2S MN Oz@T\ķUXjaJA596`n cR9\ծ5ErWnqaR@*4_<5Hd :̎K%nYQ ۃ*vԮ eE܁5{4rD&2U Oc3Zi[[mEGjR=AjHiv\>0Rf =LF]!|ĕ)J[fΟyTG?5KwYwmZՕ֎UUqΒg\7&~[dI]3CFtKpHֳ}YkչMIy 4W|TZܧTjhhoi6}RBEX9JNGjbt]IUKƏ@ YX38(%hQ V|NM;EUC M^ӚiN&m68UiJQW8Ԫõ|klҶi6**.0!*>6G_x]&&$H\rM_"fh5MmHA>jn߁{v*m _RxAѠџ1*}TYjujM<-RZF2ʒl.j1D5iBRBI#W0n3Py!Ns\Sm/# Hd0clK,~*۞ceqdd9j\Tܓ,(ty' 8BPOGXuųN)JG?z^^o`{=ct{й Cd p~(GH \&Oނ)uf<1՜ 7+k -t%= ESTi;\5y+R+Wty(Jw=^Xe^[~3 wapooqO*=h$EƝy oPn)!AAC괛.v wҩ_l[5 sQ22OѶVq\XlhHPc,մ@AK*RZsÏ^Nw`CkAI9$9H4YLj0(4^+PRqNLYΤS5y@+5]il.Hj;R80a=Q*_)Ь'1T8y݁q*TIq7ry?Ah\ҥ@.QooI 1JP*Q4`z OtJ;`WLЕTz}]MAҥAZAJH.m04VxZ?