JFIFPhotoshop 3.08BIM@Rosiglitazone protects against renal ischemia-reperfusion-induce720260819PSCIENMAGUAuthorkRosiglitazone protects against renal ischemia-reperfusion-induced lung injury via HMGB1/MYH9-PPARγ pathway Science@https://scienmag.com/rosiglitazone-protects-against-renal-ischem© 2026 Sciencehttps://scienmag.com/Acute kidney injury can damage far more than the kidneys. When renal blood flow is interrupted and then restored, the resulting ischemia–reperfusion injury can trigger a systemic inflammatory response that reaches the lungs, where it may produce edema, impaired oxygen exchange and acute lung injury. A study published in Pediatric Research identifies a molecular pathway […]ScienceTecTechnology and EngineeringTechnology and Engineering'acute kidney and lung injury connectionHMGB1 and MYH9 pathway*inflammatory mediators in organ cross-talk$molecular mechanisms of organ injury5potential treatment strategies for multi-organ damagePPARγ protective role,pulmonary edema and impaired oxygen exchange!renal ischemia-reperfusion injury#rosiglitazone therapeutic potential-systemic inflammation in ischemia-reperfusionsystemic inflammatory responseC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" S  !1AQ"aq2#6Bt4RUr5ESs$%378CFVbuv-!1aAQq"2B ?;:a5jqR]({7sQSS-(J %re9آ3~T-,qВT2)>}HcZJ@$x>lK:[QC};Mo15KSw1=H]luq35  43)P<ԓ9;(*@*ӰÇPܮKsv;֔sI%r\öBq6? Is4)1pJOB} !.7)0Z!s2U.])7l k[ M)3~#+йǹiNzJACa=|Ҹ1?SJIIpPT"}zp2hw^IQOyWLW9lSp덀ה: +ca(<hjޜ*BV[ӭQEEPY҅mzEJSr?ڒCߦhv6DpVTqy<8"C|Dq(Hh Q;z"@INcL (jsI]Tbx-:5%'\BIP5M[|U_ܿoj֐&ҙ)Q՟<RyP1ڡP'?YmiU[qx IlySԋoj,Rs6C8 _*NO#]fSkCy<>!:ĕH +g{oVɖ{Ӭ\ P')RT20|zwtSB C^E,TtZiRQq כ4FԞbKiu)k?4ͩY)$! 㷑6¤)N Y xMNYeJfw$q-4JD,ڵUišKe׎j'V eek yJ?i 6hҤ|AZwj(/|ws},Ř(8ܣN)f٭sՐYM3nGQUiSsi*Jk~.`Mj7$+Apq>NRݝ Jl/S_QHX\kUnfCa)eqiSMeQX23_dՌ-,KCa%XJ@PNqQӻӝ7@ תN3B[S jYj0rJJZo;607+<{f7;8!2K{O苠⤡m'3Wt*LU#^i:I)lNhn8gu5E:䆛֬)taA#T->2q6KPPqJ/ދ:P=x 65H3ys-ޮ 9g~5 8N䞊%J=8+2m8ܖܩ%@:S^Y`iS~J"vgiǠupH$ g=o $,=E%=ٺ$>C Sǜ'-;] TQ!$7oI>Ҡ:g4։o@Jtx{5 6a何yW*3%mn~vb֛[պ3Hx@Nq>gŴ!sw;@ 䞤gHʇb%r< v,2a)wkψ?h #8}xՍ}z>ܛbipGNz!έzƹ~) iԤmhzJTܟä妃aEW43]ZNDmC)Zd dy>}3{nɚR 3v+p3_hq!*WMBB=sPNf]r)!}%NUzLBC$ U}8κ)^u!M8ZF 3X1Ea^yuda^'Y25L;2x;cmÏuG{B@h%<%%8#cTs\Z+r ,"BRxOkY~XBJ\&ɜ xtϥ V>(#Tp\w [&ݦ SYVۊUvNLK4P%-GkxwM>>c}:}N۾O{~C$5j쏳9V2[JOpUYmMw_G?EO_ӲYy{Q\U9ؽ,@myNzPݼ'MN&:#^4d4!Pgwkzs1OlV΢zk# z^b)Zz&H!x>9-rFӚTPzka}~s_QlV΢6C][\gܺXOtTxVHʊ(Lax6:#;3 ȸܖژ*Wx%'}ʊ]v:Á0gƓZ!Jʛ!ڍ >i}} .ФiT&f+Mwy)ncv(#.4q[P8k 2RZRTp3]*!:MݲKl;T 85e,E2C,! =R>y+Jd[b%n(d3jEe-crԊ@ղd".FA6# 0x,B^ߑNzӓ#3ua#%ը% yj":yu6[KR,(`?|Mk%4Ed:$LάkjGxiWyJsNqc2/Q.%X^Gr݅t}iC+}/Ɓte*$VC y֎^nz:ޭ$kJڎg}w$- nIFO#^hjL)R osmX}L]JӪ$wVS3edWe5;,{rR896sLQ>e#iH)"sj|G $Cn1׆BY^w9LK]1Yn8buP #[c sGg=#O|1CiD|Մ}Ru`(((>]_vׂv֡}/j/AIFU S6@p *ݴ}-PfJxM)jiݯPc.R2Bmԝ_!DoIHrBPIpj8E(WQdg7(&`f9npI[Ia24FFO=sӜSrِqkxߎ5bBzE+rJޘ!I=A枢y>$C%H(/IQ '2<kRia"{+p*U+ƸhZ#avT7}Y=n '}(ݎR(Ζ]:M)''I QpYut֫J>F ]-J>)GḞtuBDeH*x+}?&e49yg;IM+vw||4]Im( qyU#԰#?Mm|Ycح(QRI8EnȞݚ]ù9xKJ#>;R9F2~uh(/͋hCYin!+XIQ\|4@ J]NAAI26**@IX=(QEV^tmŖY%M:ũ!dϖ*}ڝŷ"+nf{{<F 򬓓.2CK;'TwE(*ЕRζX\3\Ỳ@òq F'K\YvC1` GVK~k OH u;%]>iWOW rAO*Gugk岵Jۣ{c||"m葏 oOṰ|CǮS֤GgS>&7eC4ui)$x{`|Z56e^/kSkDgn3"V46PN<\rH2-%d,7ד5 秊U_T`un9\lN6ugg["="Lݤĥ*ϲ35:Oge=eVwI?]P:[Z;t['ƺ[iŠ(g =%;]ǰSG 0~CKA*[IG/e<ݽ5"[{w$[BϟN+aQZ8eRXo_skv}N$}h 3;@!Q[qp[>3*(LU+ZZ\Amh\RO_[ń&CT6JХdmQ+I#5e#q&3KRgM)I' nF=5Φ:xzПhd(eg#k*+ctމ?_gNLb:RN)9ӾaKFDk*)RwZZb3gbZУj+/6eIhMXO_[]-"* ^CeHՍ%dM?UNg\yi 秊vV_Sr4=:9}!Vp!C'~4úZdT 6@?\b::xxss^er竍Sh/?mjhˣ\wB笥h* 'VR7J;}WGDR=ZQ%EQE\