JFIFBPhotoshop 3.08BIM&@Brain-penetrating nanotherapy blocks haem oxygenase-1 ferroptosi720260821PSCIENMAGUAuthorhBrain-penetrating nanotherapy blocks haem oxygenase-1 ferroptosis, protecting brains after resuscitation Science@https://scienmag.com/brain-penetrating-nanotherapy-blocks-haem-o© 2026 Sciencehttps://scienmag.com/hA new study published in Nature Communications reports a nanotherapy designed to protect the brain after cardiac arrest and successful resuscitation, a period in which the return of blood flow can trigger a second wave of neurological damage. The work, led by Zhang, Zhang, Wei and colleagues, focuses on a drug-delivery strategy capable of crossing […]ScienceMedMedicineMedicine*blood-brain barrier crossing drug deliverybrain-penetrating nanotherapy&ferroptosis inhibition in brain injury(haem oxygenase-1 role in neuroprotection*iron-dependent oxidative injury prevention-ischemia-reperfusion injury in cardiac arrest)mitochondrial dysfunction in brain injury1nanomedicine for post-cardiac arrest brain damage(nanotechnology in critical care medicineneuroprotective strategies9oxidative stress and ferroptosis in neurological recovery8targeted therapy for neuroprotection after resuscitationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"A !1"AQaq#2B3R$s46CSbr0!1Aa"QqB#23b ?Uafu]+(%t{S_jd)0"2SB*˥o"Rr)Hr./WD#wMQ)YgǞȮ|g h WIquNUj(.1.4CiQZ캬3K)!NZ]tT+V^S6/q=R ǽ24ʆ(DN*,"y? 3c*,3܌Z43zDuISUӊ^ fuEMʬ_J4OZ+CS1YJNըFnc('JA(WS/]R(y4(]jUv\h)5˸hBkV(Jif$ P֥N>˘D\gSgj])V42e+, xCi;†o7c)Jd*:kFmlA\a:ݷbU4T;E% * :UՂ,VeJpzGTn&JQ٨uADdi[}"rfy>^kދE›>03 q_y;kCݚ~yJNܠ>$-XWZ6(2y*πbfYB<2-A9.6>^uk._|}Fr_%|;dT*RS4ޚW A "/83^:C`iȉ%D{g:5pӪp{)QpN}*cMv:'SM+t%lϛ`7}G'QwO[avJKy0q^7&%F0»9I"5ӟ.͵0i7HiXSy#K\oN} KfԚGN9/.SSJ4E{*K PBw`8\Xfjn2*f;. 8CR(®M )USJ۫oRRVTsM3N#8ĄnZaޒ>h.P;8hJK#%k=2(gNiO *yUZNb"kzDx~TuzqZvl2w؏p/kbmIzk pw#VSt%Kpe=r|8˂;t!mJJ z76j7@iB#q9ǗJr+SC2J$_`eIy斉m6e^UɼNT}&%pd|QR]0:3$l k;1[rW;-%5 A3=FdS)-s _<ӇI_fZC|WNT>=&0\f$=? 'É ;y3Y2Kĩdnz*.#=0u$~?CD/̼vC2el-(LVt>a!M ($-JBJ5Jo5n3l&Sj P ͩf}H_h³ҮBrbA)ʈ¿5x߰oJ&DOm"-zms]7;Z ~]6JX'5jruW+Dy|G@c'EedctQR ZZ;C [O7%)9檈obve%EE'K㆗ip!&xoTMnҰ\??1iǵ-UlZQP.1c9%ɱYTbh2N N%ԍŰh :OU{jaX]l)ӓP"v.LFyc&:տ>iuekICl( _Wf*J 8ȧѽ_:bV nZ[`}:f4_,O}8j kҏi`W(B@Ϯ)&B̆0rv4yVV|2S~btthkWpDN3ψ4޲fiJ5T[8,y4Vd]OAk Bw8ϐimϪ#Ke=*ֹĻX߂{*X :dzךݴY-Ǵ(6 =k7-D,_ =?,]ƌqRя1^MjmYI#I9p4#? )"-iEV"u6f[{ OWZőĽ#m)PE1:X sU"xRLtmycj|WC;Ysr30RRx8"][YR:O-7d2z|!**2Izpp6FF3H҇ޥ9.t$eq"jtn\Xi~JN(ਁU"jw`pDRc_DTbk{;_uPuR\œuy*5?`+pqrL~VZWHOP&HRB޹⹞;˕;[)h~+?қ~045 ( :V -V Ǔ | K5MM