JFIFPhotoshop 3.08BIM@Succinate Worsens Obesity-Linked Osteoarthritis Through SUCNR1 A720260822PSCIENMAGUAuthorwSuccinate Worsens Obesity-Linked Osteoarthritis Through SUCNR1 Activation, Succinylation, and Mitochondrial Dysfunction Science@https://scienmag.com/succinate-worsens-obesity-linked-osteoarthr© 2026 Sciencehttps://scienmag.com/|A metabolic by-product best known for its role in cellular energy production may be helping obesity turn osteoarthritis into a more aggressive and destructive disease, according to a new study published in Cell Death Discovery. Researchers Hong, Chen, Zhong and colleagues identify succinate as a key molecular link between excess body weight, mitochondrial failure and […]ScienceMedMedicineMedicine4biochemical mechanisms of osteoarthritis progression,cellular energy disruption in osteoarthritis5impact of excess adipose tissue on joint inflammation6metabolic link between obesity and joint deterioration"metabolic pathways in joint health&mitochondrial dysfunction in cartilage/mitochondrial failure and cartilage degradation.molecular targets for osteoarthritis treatmentobesity-related osteoarthritis1role of succinate in obesity-induced joint damage)succinate signaling in joint degeneration0succinylation and inflammation in osteoarthritisSUCNR1 receptor activationC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" O  !1AQa"q#26BUrst$4%3Sb57CRcuv.!1A"Q2a46q ?nw8vfIfa8Zԕ7ATCǦ.ZP]κrFzZSz_EXV֜N>@PAidɯx;.shXr'ȚGumtcdVV9ƀ- =m BTΨTGJXǷB ۑ ʛaZ!il%MGQSUƭ/E Yށ nn{i-2K*JAľ+KT)R+n{r.M>)$y٪6%WbH%iJqOƴo$YfKH!a@YfK҇-8%ʝpZ;1r'N7䄀yPitSwh]n[> s/́i'LR1$Zd;*}dv]USLǙ>b:6=˥{pjzFDJB@^:R|LUOp2ugjBX\ȤjvDu +EgE,=k5UȘI{{2SLrU Ý^ۺLBe)h[y1 ̻\VOuV.z՗%k8iGUFw(\'s嚐2fک}|;@ .\G>u<Ȑ`n\pn@uNlxҧ9"wQ<lkt>eH12T3T}M .s+VFQRFKKv%J( UBU#,i\sgwۏ*(KnG*5))\JH4[qtjf8P#yT/ZjW)~uFT 8c=[ꗒqW`$2#>*s~' 'Ӟ)v6H$ 54-9@&CV9SN$tz"5[!vgT 6߭5q,7ۏ*l?q[S!2 OFQfS ? Q:>@~1%5¹XoU:r29MibWcAnr/6= K/ FG/ZZ@Yw5 g*R[OLUV{5;`.;+,ܥu xkU /:ݸI҂:ȤP6;6RTvkNcۏ*\]H3p]k$)}cKE˶M RA}>3UCdT뇷WUg?$׾=+ze,HJ6UB O\d;³3H¸r| gyqSHVVxT]4(6=529s)![#@i֠mIX5 O$gE2ۯ{KOҲ*6J`ZdgS]w%D$ xL_Kw Hw9'+vlƢC ?4|({𢡲}iWƹ`+lI6r"Od? yPB_I%c Ɯ׷}9jҚRCQ&+=+V6PU p4G@kX^_֨sF󞑎xulsqݾ:W=Uĭ7RR}@@CY&C)u)ڟHT_xP 8pr4i64E8%9Qzٽ#5!1Z9.;>'ڠC,Z#n TZ7%HclU25\ʴL$mNyTsՏ7.v֚l5 Ep7;oVhfne` eeEc}c*8nTc>eܺ؟K`pM#S7$A4͌t[G_NYRAx#:>9=*3tJRЭ.5BۙRdpuBUiA-$b 7eIȴ[T); x:po[I'5j~ermwyG3I;xt_i RE`~Ծ|? qǟ?ws5O͏=d}~,C[GP<է ?>Vr:>)8_^sqeu+tQxuA7F;y(zu5d9##EIjڢLrƝ;LuKia<@?߭(J}i{g;mhY {Ӝe.HZY +Y=D(r1];miZ}ic)9(T~6zpԨ1J$*q; W;s+o˃ m%C@g|Ӛ֋ڙ[b f撼\QfKSҸ,%4I]$!c]Q\6~ڬV&<z:= |NMnkO%k-:W8zu+XТ( [mĭKR)Hc.yַư[0V|>VM0K8IV`դYzb+SIp7nӫnȶ[ZvԩIQ@[9*ptNC-xJdGXRBOQ'#mś[oj2>dᾓd90uf^JCqKUKr4G`6ӊ){Mk*KoK,eaJep)U9*H*]gde|lnr@+-ANj)֊QJz.<9b6" kLQPZ* tp\R1mT3x .ur+O~GCMr#Mj5O$]mx a)C>ʮC{vF8hj$v{[RR%@JU+zϫl 6v,ICQH98W{Q^a^&zN3kdFˊQRAr| W.L,3:9hq(N}\4d#omUÜ ( ( ( ( ( ( ( ( ( ( (?