JFIFPhotoshop 3.08BIM@Dual-oxygen pancreatic cancer organoids mirror basal-classical d720260822PSCIENMAGUAuthorjDual-oxygen pancreatic cancer organoids mirror basal-classical diversity, spatial transcriptomics confirms Science@https://scienmag.com/dual-oxygen-pancreatic-cancer-organoids-mir© 2026 Sciencehttps://scienmag.com/XPancreatic cancer has long challenged scientists not only because it is difficult to detect and treat, but also because a single tumour can behave like several different diseases at once. A new study published in the British Journal of Cancer describes an organoid system designed to reproduce one of the most important forms of this […]ScienceCanCancerCancer!advances in cancer tissue mapping$basal and classical molecular states(biological relevance of cancer organoidsdual-oxygen tumor modelinggene activity spatial profiling'molecular subtypes of pancreatic cancer0oxygen environment influence on tumor phenotypesPancreatic cancer organoids.pancreatic ductal adenocarcinoma heterogeneity*spatial transcriptomics in cancer research+tumor cell diversity and treatment responsetumor microenvironment mappingC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"9!1AQa"2q#BR$34Sr9!1"AQa2qR#3B$45Sr ?BNڥ/zzh%N3F5gl[P #tu8t_ }Up*úz}ohwO\ǫJ#>@BG\ylEGmBq]^,Gsmu?΂7OʙkC%##5EiMwq|$PC{C/ۅoe@Q#֍Вt ;ғwۯgRt'GGu.Sf#UV6dHXoHSY)B0'8'u){gY!W99uW\ÈAG;k+u|=1HKA%圐3F;q$?B}WRdm+X|TI㩯Wt\TޝԮk 198/WyOik 퀦<\Z~Uv>R)T $FXVJ=I44V݌|ңfe>dF(d$ I'm-9cLGRҷa~! ΡԫciiOgz)?mPrԞjikv>XpVG`E!J #j:a\ hqj䰧yg@ڇJ*RBJB5uSU7qqq$$49 4ڒ'w+l-AVfr2]w T) `(|dOd! Y3^YJl(`ZM{҃H];Ԭ<ꕩy[" xg+-8]CcE9fnc[fF_ogM49*u*' Z;6҆CkZޜ$pąYW1 F=r(@N#[0$LlI\ I`J]ⶔt`qY\ }J u!ZHeI3a{&ktRR,zUs'pz8 {]жEktkMx7a%v*p\'G1]Dp`Rlh ;@$In|ǐTd@.J/<# }?8*VHFnf+ \ Us4Vi.EeGWi. 1vlACjZNWp:ZYҰ0{ՖjE#?$&!3ץ%f]߸/vENm<5yvsn4 `$xvE{%Ds۫M lJO?7>SmK_07)ЭWj9wZ-vvQK N6JMG SsKg^rkc\Y2CP(ZpJb-~`su H SkJZzO8YP㰭cjIPGr+}8'U)cFv5s#q 08n6 Ivq j٣Xkp Dl\<18ڜeT9պC( 2ЀzVEJ%bIX++|sR\Z7wEJ<7<=yBZB)**Ql„G q*Fu}t\nNK`4vU3kJ粤O8+W*r lsЃ?//X3ڍ!\JsSJZqҗ =Oz9>rdr&JbCKBp)V3kiS֝GbvP$MS)#H2(:jz&J2`i [h*Hb^9q)W/Zsl AԽ Q?AYn`["+ߺ5854E-^ W3MΥ9=!$,%H'j' EJε5!- :j>w4Vc Yj'KEIBI®ӽ7oح$rɹ5\띝Q\?yئ\*R3G+{ Q[P1 Jj|'zxyr Zd\6nq(,1%(k/"kHKR!A'OҘX"2ݤ'Qҕ GB^>]>q2O\=%dk88;jW[EVܢp2yCzt[P?`}e2om.))r^I|W d7=Y}RNBLcN}O|fqmm𥤵R$ho|ś4Z")c l'T@6y\qAv(%.;򖰕,,7qGDZpT͹2HW)Ӻ\#)xXnfƢjB[|XV{ۦڲ˓ .dvۜҁu=XH.yzjA_p'ٲy$3ko\’^Xj8Wtћgɐ_tsveUGmkTpP#l7 '0aP(SE2UV(q[\`bt9ʕN=n$mG.PBdSJpI&1rjI%J.Us^١nQs"|FWR3 FqZ" ;->(%J*HF^%8zϊqFhI9˧ֲqn7YrRZdi1YjZHPp X!F| K- E}*lnp=hkG8J[iœ;4%6栴ցɪQuiЃ%`>-˨pG?OYÒMFKJLO. ?/Q3/un"[5 NOO_7(KCB2~*l'z9w]YqKixAINOZE46@j5R ULS֣ V  .,u6*B}1ڟ&C{S_4 ?k(wumz$ߧ&"%XA_a: ^ aj0/R2qXܘAt4lz)rx#i~ CbM‹nV skg@:n`]qnA9]q[vlw$Ht ֝n!n;yzTgҤ6ɧgikmqBrh\q 0RcCi=sH-`oRQj/\H o&9&SqkUYyp`w4>K;>3kP,Melp&-rJҴ[mR>GU>Yp&3s/EDNRaE1B0=!9"jKKSj'*SW2{m|A*Iq;`t&:((wUo)R+oA" rlh~LtJ~!0WZ2AG#Ut7U6e҄]=pܲZYM#[FDY;Q=)'0얬j0 `n;hʴapT3$eMLj6)lJ@}6Lp}OQ<)jep ć$-=H=3jkgOZ., ml ;;QIKB]w3i7!H* #zpmՉMuUL/t܏IvAEĨΌeȀi=3YE\!Z.˱ \W$J}d?)%tCJdݚtYLeUհ=)OpT/zp:/HNP+%mueJ#י-i>G$}#fZ$o7:R:~Z ) ]33`*xKLyHHʎ<(uKyoԥ5Uog'=VˮmǯY@rcA @c["ʈ5-@5O~͆('jWPݳ16+{b˺ \&Lu!`OJU٣l7 =jep!#}<жYKsģ=wT^fQ%W)$EwY\O֥Jd,/cUkR=O#I=ے Ӑq(l:~wRnYwD$w֥J#L& PI)gfqI$ jTmWW?aR!V)*ԍ]{ HỢ^m%G H;JO_V)%(2%!' ҕX*TKGYja\Nݍ4,J; T[: [y<2qJמ=Rv1\IԩR