JFIFhPhotoshop 3.08BIML@Blocking glucosylceramide production kills cancer cells via lyso720260823PSCIENMAGUAuthorgBlocking glucosylceramide production kills cancer cells via lysosomal dysfunction, not ceramide buildup Science@https://scienmag.com/blocking-glucosylceramide-production-kills-© 2026 Sciencehttps://scienmag.com/Cancer cells may have a previously underappreciated vulnerability: their dependence on the controlled production of a membrane lipid that helps organize the cell’s internal architecture. A study by A.J. Straus, S.K. Kempelingaiah, S. Nguyen and colleagues, published in Cell Death Discovery, reports that blocking the generation of glucosylceramide can drive cancer cells toward death by […]ScienceMedMedicineMedicinecancer cell vulnerability(glucosylceramide biosynthesis inhibition*impact of glucosylceramide blockade on lys*lipid metabolism and cancer cell viability$lipid signaling pathways in oncologylysosomal dysfunction in cancer,lysosomal stability and cancer cell survival2mechanisms of lysosomal disruption in cancer cells3role of ceramide and glucosylceramide in cell death*sphingolipid metabolism and cancer therapy.targeting membrane lipids for cancer treatment7therapeutic strategies disrupting sphingolipid pathwaysC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"5!1"AQaq#2$BR32!1AQ"2aqB#3R ?$ bXԱZwz SP"Oө)msI0*H6sި[ctKeh`\0qR@뻓\y*j%*ţs]hZu+#;sk75kj?OwbOoh!^WFݸ+SJTgAd5 rzW:v.%fAޭJk:ņZOYCp V\T8&=V 1cV׉gBjds]$n&*Nɯ*kKfEFdw }d )Auٚ+ f흪ܱU֭{hn#6оH{=5 !ᵵ-pVbEOtr$R0A]ŀx:n:u¤o#@K+]˨Kk+x'fB>np|Y"rI3GE'1s0d1^ݶ^QEZD4i;rFE-2ysC׺oSF˘&+W #\֖%ց`i1KM 53ch=3 Gz6Wqڡ=` t׊XVf]sIFIZ5.$#|Z #%rASC1$sMBXy*2j]kTI-66B=&5ń%CѾ> 1^طGQyC}~7<Όvc iymvJ &n4.Y'GpI5onIy\gr] 1ݏ>R?Mi87[ctd\`!EZ,g8+Uy׊FEE,q򄜃&*{m{'S5#A$x +#5w^oі݇u[PCS7KS|¥tV\>*ڮ!->%B.k֐5.jr*ѱ6 Ke*O 1TV}tW;HA'k4E) zn?c\ZhOOo "Aeiጊy^›H,V7v0RF?P*;5IVC7B{s%p\NW̭P۹=4Q:o&Nm`kE[p4VGfidujx5ϥI#M dd v[F m=[Iʼ`>G(WU2'L;%Kj:zksZm5±}FG擌ZLш!W?˷{(h-ONg4Wַm?Wퟻa.{i{=-i$da_OoX'3!R>j$!:7 ,FŜ>]KqX̉,/'*ߏڳT֟5ՕX EPm*;ojae$Y c"9봊0dT8 |Tskz\[XJ1r?zcY&Jb!o#JC9_vEY>t䀰ÍȢUxWEt&y+DOѿV,?~_c?T_?DR05bn21muCЮ3P&VLh Ͳa%evc+F=:0`p88eɭig}n#!Dpyڬt ?.=tj,Ou|Uyeg#v*Xw禮<cҪA:ポ٤%'g*_ei r Nj'+w[L*&3縎XGe*s{c{S?ev@rC ji{>KLNԝ%.?ҹ_M-]crI(EGsF rK d}>+lI0Y+wg8ִ%H,c*Guph?~Yȗ86]tm7Y _p  <}VRKNܳ}@J+#վQK]jڰuKP4G&{oеYdQLW0(!KfbJC9Jy s. k#r)yl0ǭgk Sd8"3i.g rڔrU\%Kwjq}V3ikpj);NZ- H_C"2 ysߞ}8mfa|у́'- #&4MN@|GZD-C$q!*-GiҨаϭaE6]Iw=.0`lQ? asۥ$McFw?+xjϨ$vd'{B1\n(/nle$2c⠢ $d+8Eӣ FJvYٕBxQ\^VtwQEYQQEEĸ"V \Mrq{Č .%V/[YOw,lc*^YMc{ $nbpd]p{*p3vZwcд"DL$)큀2G<縪+By_G-{T:.w=9v0*8ե\(Clv3QU-( Pu^PA^89vQ:ʿXǨecw)#7.##W$ԗdmWasǓ3y}c;ilX.E <|qJdℿVDwm>| s%׸66UX_ 6ę$VzKze\>捊Q nf?V[Z+ỵjd#; 3DmR^ḭր,t8'#zK֏6' o$RR1{!"Iv;~(QLQV1 r(H5qx<1eHn9b>iS9L#l3ڲ:ruEDsRH;gc\șcn(WOkVthNFA/[B@ITQEut_0mLGxU} Vm,ٮ^+N8ei.%6Yni9{ M7j#`Uޒ̭ 2\◿W>_JJGd^9ٓB,)ah:4̌=*BR7nމt]IףyE+ X"Y֤m.dhw0n=j NyYw+ (z(*((kE|qLY~j(?bhLwZM,*ohrWB(ҤQEEQQDQEEQQDQE_