JFIFPhotoshop 3.08BIM@HisToSpatialCNV Predicts Spatial Copy-Number Variations from Pat720260824PSCIENMAGUAuthoroHisToSpatialCNV Predicts Spatial Copy-Number Variations from Pathology Images Using Interpretable Deep Learning Science@https://scienmag.com/histospatialcnv-predicts-spatial-copy-numbe© 2026 Sciencehttps://scienmag.com/Cancer’s genetic chaos may soon be readable in the ordinary stained images pathologists already examine under a microscope. A new study published in Nature Biomedical Engineering introduces HisToSpatialCNV, an interpretable deep-learning method designed to predict spatial copy number variations directly from histopathology images. The approach addresses a long-standing challenge in cancer biology: understanding not only […]ScienceMedMedicineMedicine%automated detection of CNVs in cancer-cancer genetic analysis from pathology images4cancer tissue architecture and genetic abnormalities)deep learning models for spatial genomics5histopathology image analysis for genetic alterations0integrating imaging and genomic data in oncology.interpretable deep learning in cancer genomics;molecular characterization of tumors using pathology images5non-invasive genomic profiling through histopathology(spatial copy number variation prediction$tumor evolution and spatial genomics+tumor heterogeneity and tissue architectureC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" J !1AQa"2q#BRVr$3b7C'6FS/1!Aa"QqB2 ?uKӢ\I)oeHBӑNyib~8P>ouȏJt2- Vp#~~'%mݔ2PyUv]&u%+[R-!xsy+P:(D SR$StfԀFI3]xHfKB`8JHD䜓A%ޔڔj9Cdjk+x^{ۏョXBwϡQF͕NF 9W֍F#7 Jc&Kn$eZO>! HԯHm.6qɲb@tj\4.cdn @*kc ׏Rp|&bߤǬҊ{Snn:t†9`12F?N(M ~@v8;sfygpt֧ZtYA\r_-9pt7ݿУk~,mNp|״d(ewۯ葒.me}?YѢK4 =x6g"ԐF~oz js{7&.}2m!èe. 9'̀Ҝy%mR6k4Q%oz}9yhgCӱKi4%>> rsݭfGnE]ƻKI*@L4zTNAWR|B}tt  ya/Oβi틺QYOg c [UJ9oouIDClMCǰBTD( [mGji5Vs`I hpZI&JӘqMru]TfPbҟ K̔:~‘O=55oݻ~1yoY6;Nڒw+RI'gZR+#CߕUVF2)M#1עK,0.i`қZ 1IZÈ %œcbNxE:rN-w-/5"!h6~t0\C2S<|NNTg7 UmG!#J4 ftH(_p)t7T}XA^Gz✣dÉ.>/6aew_-nujZpRb,5Ǻ!I<P<1wb A)ņpG J=|<5\YզI2eIqCNN sENN pSҽүwjWnME&sfώ9|ӣQ]nU'وK\j\E@yO=5rTnU0wEԋMC KX0#Q%-gr*Ou5m]v5AeХ(|=5nu@qT݉I):aUaբ%I Bp? 4# 1^ܽ,Zk() ۏ.UU+/c(vkX8z4D <_'WkNшPo+{dm 8 8X5Wd}ƁqWH!/P NT2xy]NDŔ :AIA0N%-L8*0q*h'́\jI.[Jkh_z;zM\ N̎DP/.g/e`<)1w[Q!$݋SiǙp؇d^Ky0{scBRAWrLkVj%E60y{#:nee1$JR kG3Ѧ)/$TT%K9PO}u!1yڏyfLA A 9 :݌w )X_1h},La2VYvxp>Cc.lUKRIC (pώLRiy& R=t==Vt)4>HP^#0w:souj|'jwi-N 1dc9es\tތoTɯ08{5vcy38 VRH)j1 Ђq/JV^RiBIq Q<ϮN4/Rϼe{9ߴ}?1?L2nX_@>KI}qM%s$^2z :He6%EضⱝT(|x &L[e4DŽ.5+$̓> Wm ڍ1n.:Ҭ Hn9?N;f O C\ƬJR2 1V\PNG2x:b#>LgbK(|&r*NGK5D㵴(HΞu,

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