JFIFPhotoshop 3.08BIM@Serum Proteomics Identifies Shared Signatures in Hypermobile Ehl720260825PSCIENMAGUAuthoraSerum Proteomics Identifies Shared Signatures in Hypermobile Ehlers-Danlos and Spectrum Disorders Science@https://scienmag.com/serum-proteomics-identifies-shared-signatur© 2026 Sciencehttps://scienmag.com/A new serum-profiling study is bringing molecular evidence to one of the most difficult diagnostic questions in connective-tissue medicine: how closely are hypermobile Ehlers–Danlos syndrome and hypermobility spectrum disorders biologically related? Using a technology known as proximity extension assay, researchers identified shared patterns of circulating proteins in people diagnosed with hypermobile Ehlers–Danlos syndrome, or hEDS, […]ScienceMedMedicineMedicine6Blood-based diagnostics for connective tissue diseases%Circulating protein biomarkers in EDS9Diagnostic challenges in hypermobility spectrum disorders7Hypermobile Ehlers-Danlos syndrome molecular signatures3Hypermobility spectrum disorders biological overlap(Molecular differentiation of EDS and HSD=Proteomic profiling in inherited connective tissue conditions.Proximity extension assay in disease diagnosis/Serum proteomics in connective tissue disorders5Shared biological pathways in hypermobility disorders+Systemic symptoms associated with EDS and HC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$">!1A"Qa#2q3BR$CSbrT5!1A2Qaq"3R$B#4S ?6J*mlP\s N1ZDf1|)R M]uM P{m 4=WZ`e!2)f2\pҗRg8ydQ9m~{QጱF2Ǖtn*fj{Ӿߔ Ҥ[%Q_P2n?4 @{V:Լ.yMYquZPCeuSwڄ2Ɠ)7GLi+N@O9LI!%aj [UuKtڝFy}JwyʌVOJ-ri{fBGVJHH>EJV; P-Te eҀ8r7Ғߐ(N,䨞k{]Uii.xL!;|j%ɪކyE!Y䕻%Gb7n^})#}ߥO& djV9Ne{ Hc%J,?y8X*[O+`4tuQ/!RBJ0Q=w'<Դj F[rkԍQpBV PIH g\ҷc[H'>=fd];9.N(:pJ 4hȱ6N,'  z<ٛoJr㳒0H~ʻ1Rv穧1(~TJZ.u:@WG$]\NWns^\GZ+:TOO$䨤qE3S&rB DnOq\=Rb#[ꗒV4c9emgUw: ^%4Vsм5ÓhMu(AY)2kSIOn4UxBjJ=:qpǟڃ@F37N-)8>/N BQ[@)ڐ$d|.ީS7;u\J׃JA7ۗǦ%% mKm$H?&pUb!:n4DdBVcqL. TZ~c(2zӹ-- g *N:Xļ3a~뮓G5MB/UıfIO`Uɇ1ʔ0RǨ`n?J:M*jڙo(yh=$|F# sY6|IRoٳ?JCMSԾTbtV'pQPgF,3 %JrwNZ9 >=IpnReQ4eiTJq!!'#NeD6Ҹ)#eDKl:,Gʆ⑒ORB>+p"澘[gh%,lNu$+zS\1_p}=4haCr7pF;GJlJyvQ⺁L8VFHjޠ^έG"mL\dG⾡y@ ~,E!2]#/+|j3d6ێ,QEuHNA[U H=<[t䟨<=I'lp}BN/^y3|ccڎlP亅ArB+ŭPChR31rl)9W8Pp_z7q:tz }$%$`d`wI|3^Fs9>[oU $נ1EvĻG &K#, ֵVSY@PRJ~Fs@4Uk;^m2\Z-#JlunP~1Xdr*fLpuTo:jJbg$88Z^j+Ja 5`'+-7zҷnSKh Oi<wqC^`Oy~i+i(fDݷbAA'*tDYǂPp)ǾO~#&li|Յ )(O\ \q%uQhmvgh'Q?6땛ΛJR3,V&8lI+$.D($ڻ=_{ :#-i9Z\sC`c[^Ж䖡Z2w- p, g)tyzrmD}qm);HdwW.yJh'} hë Ҭcv;qu--@SHc8|Ȯ7lMBmUBIv? B̽[q  ش4r$G_ne]]$hԹ _=pq^nZڻ]F;n;_QnݔeME261␎p5D6c__:/۞7TDyK ᘒS5>BJt:r9) zfr<}zO-L q9݅'17: JeRЛ-D~Chm[AVG~ ^T=II# G?tlKң:7zbp_G)BB*JA9RNA)9< ˊtɅeLXQ) lo}4(\'ۅV2@ )B%S͌{JYy0ثHs:V6%'ɷ6) 0oQR΢p{~߇*_c1C HG>=A4[:$dga$i]'4̌%hXڔk5\R[)Mrђ=Kn}5+/JJmJ*QT'ҕ܉e(9P6g Pq-E\2% lJ fY[-_ԌNX- #@- 5. zPܥ$pAk"D5A:ϥzsSJzrϣWpz^Jqt؏jӮQmrC@d;-8f8O-FHVeNfS.HHW? ut2, ʓz~h0e‘*A@Z\q<J [ul/$-d #ՉOd(.l_\Q)D*RkY4#J]vVֽ)teFK]2U}A5hKnwO8YK+2_!̅C!mJvXxZ KX9ܑc)[o+oX P`jo+dRw =n#ǟ!]d^)[GK$ZqsPv ߩ-昝;ܕp+׭׿Zy[zckka!W$ӵO]8 +!k+r6s5H(i=[dozH[v=SiyĺR_gVScJUp@WLU.r#:Lk[fJ`HZ\#+8&FsRmCuv6xԏ"-۞s>kZs_ҕYܴ-뎦 lQ*qC",]@+/PT!EA895kM˱ggCGuT- %qS4 Z\ )Gl2*V2({Rqإ2=eYWjKخjLeJmAJW P1&D$\҂em8/ԢflևPz$PW0T*Ғ5f+,7>O"^RW90$VÅE|LzcowmC ?_,D8:b7TTR{.o޲I?Ur*QO:#W}-;z7s*U_|j(Kx 8WXJF/ڹ jKΥJڿ8{T[jVJSWn88Jg|E)GQIYw