JFIFPhotoshop 3.08BIM@CXCR2 antibodies target tumors and neutrophils, enhancing immuno720260826PSCIENMAGUAuthormCXCR2 antibodies target tumors and neutrophils, enhancing immunotherapy in ARID1A-deficient pancreatic cancer Science@https://scienmag.com/cxcr2-antibodies-target-tumors-and-neutroph© 2026 Sciencehttps://scienmag.com/aPancreatic cancer has long been regarded as one of the most difficult cancers to treat, not only because malignant cells are often detected late, but also because the tumor builds a biological environment that actively shields it from immune attack. New research now points to a dual-action strategy that may weaken two critical components of […]ScienceCanCancerCancer"ARID1A-deficient pancreatic tumorschromatin remodeling in cancerCXCR2 antibody therapy'dual-action cancer treatment strategies enhancing immunotherapy efficacy#immune evasion in pancreatic cancer&molecular subsets of pancreatic cancerneutrophil modulation in cancerpancreatic cancer immunotherapy targeting tumor microenvironment#tumor immune suppression mechanismstumor-associated neutrophilsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"8!1AQa"2q#BRb3$Cr1!1AQ2a"q#BR ?Y=I BX<f]pt"6x-}Q7 "7B)LvyR$!Fiw9݈HSQM(cKOkI 檶g(ĤۍALjb{Xim wdgGշ_LH[" ~I?EM"ƜjN~i/-nbL N\nS=G5F # _PhVIBF69FOXm,Cz->[In1Op{]J&30XS(줊+'Umlnh{ `}wJs<0Դ#QOq muQ^kK6{Y!R 9Gz/fR1#1z&Bz(!TicߚcT$?%}  8Y{}-mDtVnǿ~F;GVX!bȇηs%0f*$I{RQMTS.T;VMtfn FzEfŦ0 8aj-B;K{38tB$ħTsۉiJ$ˏF*WU$k\|"R48" 4K5<4* J85qZJQ$cF m=3JPkNGMәjKcq03.5"MU1?|Ҿ3il7saIc<n7y"kr4ɧery$B {7FݥI(:{Twtj%n8a8œF֊g-MSpEG5A\.sqsk5єn-R1-LV7Zogo5c bqsmɧۅҖ6=a',֟pזN U 1^55Aq+c>"ŏF:# e1лp(=i7rEdAyJfX]dCzƵ7]:$:nogS^3Y{~V'J9rv`onZ^Yy*#9X8Bt=|n쌆]g,-9.^HqEc)flxr­{7C BIǴ(nKeazL4zSuJCkg=4s,g~wq7˵S`dF{զO$\.>W$Z5Ն1,,ll%UՋ8j_" 1<;"%1 6](ϠcJu)}BDvfqe 6=E1qu5ԛbH{V+ifj:2L)QK$-7doU84P8ibf n83(oވVihK%kZ:2bv*+ZZM~V4MmPeȒģUaN2m-uihgI*<5WO$0s='qӺ>]aݞA?:JwPvnhE׿VHd% Lh 1EIdg=}{F\lh7Lgr3Bpc^c3m^%#~z%`YUTߣaes4QR!4}(;5֗'46MN0731QZ'Kѯ f;<*Dy*;v RayB}3W=Wag{[{Ȱ]6iIՇ_K>/L}{5m&=jn$wO~ت}Ktx `ʃv+u@K=WEy-]^K#QN*{XDDp )9uUp l0p Ĵ(>C=`ߧo~JΌ}חʤ61Hg-hI4g O6g#| OP)SKWd%_-I=.KB u *  r<,@E?ԜcV;T+LSp8#ʩiW%#?S%\Z n7) P{ 1{_uq9ex#xQ(xFF ۾?*FJn@NU}x)S]/G!u3Q%դuc|E?s(cvGcT dP!NNsRy ImQ5jpqvA z4t3Y5mZIvև7*#x>jZh;H<ף%^ihߵfHt FxyrH\H3H[zJ%o *kǹ[:7$l A0oO h,{Y-nI@6xda>k#/3OFeWW'LCA.|1*{}v*VЎ 7R'(#TTsF2$y"7kQEBꝣXϨ_. ? E,Oj/zc]o5,SFƯ9xsXYe%hOpELB^O{cτcZvZ#5 y0FA8^2p*~Qg)upU72H~{$ x8m}H#.vQr֒$ dW.nÀs<=F+mkaEmm)-wPNT2x3Ǟ0}j>uJ\c`5kQ9JY̗H! oڵх{ :yi:@Ư+˦ܒUdpȊX/"X6-5+ ̸ʨ8l u{?u@D eU93;'3?u]t4_ʍ1 H JpկDT7+ rzGai%ȁ俾%Hc0nS$Ǟ3KX|2ѽo)i\jr+8'΢u zJP=XQY#Ϸ qUQl-m! 3HQGBL˒ {\֍'kvڥ[۹3IT%!S z.&Z'rH7#U~$jw"ap8<y[ZB|?M*9K\ڦ@ܠ f4O[гs}=Gګ߯neI$Ƙ_ 1(*q~^ 5]Jᤊ8p ȦQ j]ęyYޡ,Z!Kg=믝yNqqRNe7r(Jra(7R.c˗SM&!{pF%W<ҠQ6͌rp0;4 v_ #{v+M4Ӭho@\[*֍i߽ˉT1kRpp/}SK$gEaqy>X? <4&G3 .ͯG,2Z\Z=O>*R$7q_ıZB2D|8ɩھoo5.TF{5*;&l)Xy߮vrXmXՆz v8-qZKҥG6&P%9H=3@ܠ3AK7WԂ+ʊ)ZoxE/ {6Q[l(b U⚧-iT΢6dzm9%Wokl1*A%{dQqIkchۼ,K$eCA\y3~w}'z4O#I+wf9&Yklxu&CqzTI2[inbgˀwg##׵DlVKfHfܪU9k}+;LTtTҕdK(V+v`NzqL4|}еk5k{)f!%qsZ%:}]ؼ@qG'V6%,bH$qڰd`X2 7n:}XtRgb#MI/[-OQ֑Bkz Q u_QOy\ds+K<,rI'ܚBf $+b{V4N\ZMmqkk-(PJ{`oN#d$M#y⨩Cwa5i‡6s?Top Y2I;|Kx64Z!emM;X.֊F; #4fǀ).v>1Q ,rNMtkY9N|DڥzsjʊGI,E8 p<꾟ƵHd7#`⥐kwRUE[1D9q8[;}еt-:p!cQL2FxxmԮlgS# R9( ɿzE[KxEP*(QEEREF4QEE