JFIFPhotoshop 3.08BIMn@Plant Enzymes Enable Efficient Production of N-(Hydroxycinnamoyl720260826PSCIENMAGUAuthorePlant Enzymes Enable Efficient Production of N-(Hydroxycinnamoyl)tyramines with In Situ Precipitation Science@https://scienmag.com/plant-enzymes-enable-efficient-production-o© 2026 Sciencehttps://scienmag.com/Scientists have developed a new fermentation-based method for producing hydroxycinnamoyltyramines, a family of plant-derived phenolic compounds that has attracted growing interest because of its potential biological and pharmaceutical value. The process uses genetically engineered Escherichia coli as a manufacturing platform, but the key catalytic machinery comes from plants. In a bench-scale bioreactor, the system converted […]ScienceBioBiologyBiology/biotechnological production of feruloyltyramine/efficient extraction of plant-derived compounds,environmentally responsive plant metabolites)genetically engineered E. coli bioprocess$hydroxycinnamoyltyramines production-in situ product precipitation in fermentationµbial synthesis of phenolic amides.pharmaceutical applications of plant phenolics"phenolic compound recovery methodsplant enzyme-based fermentation%plant phenolic compounds biosynthesis8sustainable manufacturing of plant secondary metabolitesC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"7!1AQa"2qB#b3RC&!1"2AQRa ?Ero󡕺lOs+/ZŴ I91^]T&[u* m$tFɦU"!F#|̫o'M>n K bOneHy7m((=dn_Rb0Z(y;[.I~g>_Z!ohv!a+Iev}ilP˨'F? R~ah2dO6Gl0xv7q3Fx$Eq *3*aVqm{P'WuvKpg}r/se83iIYbBz|R$YN'k) E(ǡ R~HH`\i=Hz~!g-Iw(D>glz!FWXaWڴ[{ HpZ^3k 7L1U׺*w!@dץQTSW֬exS+Kwmʚ!wX hyAfO[PxͶ4*T:ZbSdoJ䢭jlj C<9#Tʋ ^PM*J7Rlm퇧:ừ;= Y`F@}Wɯ5NY6vJ&Ɣ4_lr6+|Q9$"^VSv+uLU7S !1G6W']jP@g  8]\GJxl?ں $2dF[@}7r~^re!r;UPkg8}ZZb#e #}w[M Qac£M̑PH`?l7OV%NAn'ɠMqo')kL8Sk,~ 3Nˣ\\L@_潼Û_w?3wkpPg"Wo3RA]/$q5h~"ߚZT`w[11LirJxԤ]rWH#DWo/j^H睥0ʁ~a7ֺAȑsn>G4VKW {^V꥘/:m?3.>ۭ9!T'LJ(e9+>vhBL IL**xgޕ[}TK3򽮉)yKl`HT%VarG$)Sԟ48~7<ijfr;o}FLfj,mvHBEwÎ)$[^PŘ7]n-J~YNAcyV3>LmŴyoӿO:aCZ%f5UiUu++ku_s4`N@"DV ONbuK.9;hǎ|(uN[Ȥ0#QA )ߛ@n%[8C{袈 p :'MJu6؛!T1@鿹i-2%ĎQ{%\3Hʖ|ghsFJN5Ŝ˜ֆ{ԼY_^VuM|Ty^L_ld-cyz'%/݆Tn" ^޲sJ:/i*ΉIPnF 'JB{Jv BN7)%V7ZZVsgs4Βߡ~-%p|yTU^bzVDR*o̎?z:S[ Ŵ8HMw3Bt3E<%H$G1(c_m?LŒG@η.7]h~Mú)=\!1vT`H>蓺$QjgM")P'APCĥTjT#9d`u6d Yi[1)$xoZGPإ Q@pIs#ۍvF 9P4d pvm}@TfĠVŤfX{Bό4bđZcH):tچ= po;ٿ0{`6>kgĝdA>zs[% *UҞjW/4+ /xdԷ$9dp@ T=)r6Z'i|SNJ ۢ>T4(*=4?*e"W~Ryd`^XF nYzVuo4xuUsHxgSg[)8yAܭKT4mC:8sXJHɗ)ʝ~aA)%LaK0HVo21@Dn͘iXtF#qŰE:]NN !%<{@NMBX=LAjڊ>m-C,UUNN"ҙ`G5i CuJJ2*UCC~ƻ ~*TK>vku$ڎ*j>He*H b\욀ROA¢ *TH|ޛg~VԩWBY;dRK νJbJY