JFIFPhotoshop 3.08BIM?Scientists synthesize Z-allylamines using masked alkenyl anions720260828PFelix P.UAuthorlScientists synthesize Z-allylamines using masked alkenyl anions from alkynyl tetracoordinate boron compounds Science@https://scienmag.com/scientists-synthesize-z-allylamines-using-m© 2026 Sciencehttps://scienmag.com/Chemists have reported a new way to build stereodefined allylamines, a class of molecules that sits at the intersection of drug discovery, agrochemistry, organic synthesis and advanced materials. The method, described by An, Zhu, Ma and colleagues, constructs these valuable structures through a metal-free cascade reaction that controls both the position and geometry of a […]ScienceChe Chemistry Chemistry$advances in drug discovery chemistry!agrochemical molecule development'alkynyl tetracoordinate boron compoundsfunctional materials synthesismasked alkenyl anionsmetal-free cascade reactions%non-metal catalyzed synthetic methods organic synthesis of allylamines*selective double-bond formation techniques#stereodefined allylamine production$stereoselective allylamine synthesis Z-alkene stereochemistry controlC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"A!1Aa"2Qq#$BR34CbsE.!1Q"Aaq#CR ?h:\wg A$To-mH ;6#JAXi"9IJN$d(XtUȗsyirk@O5UlDR;up < ^>ݪBokN9ڼ.-m/s:ݲlj_' ppVvJ3&46c*jYH oP̆W)CfZ;2ZY.}A1ɒ\6X#]yRB$v\/(wi~uC1-[ΓU0ccE:IW^= P5y)FZPU5u0JSQ[3 bv,i6,6Qsiڥ'b)Y/ڊos.L֟oyNa Zk32a!f!%2_8 `y`giD-G`f[Q(r׹;NAwRon(䫾*\MVuA.Oa)R!$KdJ@ [pDi)ah$yA^H KdRȣv;׸-hꥢFkF_B`aN~R`fsVS}1\7GN q0ݜ*#[ޚ<}io|W7p\S_QǺʍYju/C݇8AouR >L_}eld{'GVt[JACR۞Gd'^nzHiDGnư< p Imī9n*{iyXiњK ) 2\Mtn6{h=;BGQ#F]4Ս*Q|Bp8{8AQzq mN%C'>yL5l4׽%hˣP؊Z)07$\QkS띧Q[RQn޵iofgMa^gwa'*lgo#'^nLrBTB6yƟSwk}H,F̆L-jA 'vsV/WóۑC+ ܁٥\m)S-WT]>†]#+#CN^lf5 v=)p#Eiqe@]AޥF8qy*$RX!'}DaR cGНSfB09#ִ9&KRn.Bxb3ޔJTT7[zu3XP🟑JI\Mc˓Rxkt^+Sοikvܖ`$Z-.ধa BCI)2(R}B9y}Oj<^ה213Uω]ctV4^ RNu"9)M;xq:xABIB3*$N 7:RP1^6Iem(SڌyW?Qbޟ;ɚ9Xn.SNQR;RS>4u!a Atg *D&?Q#'+Gd34l!VP96b`f_0)+ARq:M3(PO .Zcbuxt*R98Nn0F»Gb;ɔD%Sgzm7%( NiKIͮf[)JHVHc jEhBHQ'yjk jjQ R5{]څ^˜d3S.Z,V-Pیcv9RIjhm rk5-iXkWvPJy*4SDĭ ؎~~DnwXD#wTVC.9 8h?*˪;GCEU'رz%-{T{ }+k W5;mB6xqu l ť-%-8R>$na=m{MBC~s 2_o4PZn4GLnL\4U /e 9V|ܟhpe80AKⶨI,dovX-ZvЙ |."@Z Hщڎ4Pw"-%mwzgJcqfGRHP$?*1 AZțҿ-A 8!5-Mb8Yo1Җժ'2SnP!bIBˉci# CISrTp9v0vIJZCOȚoe,o-hIԐߓ*!fw*5N6Pco% S1-F+Mǎ@m KJwvhcmM>4WX>uq}NGrS<} K^ >U֟BUsR#>ۦURpeviRbb Rx3IIe[{L⻾PHN$x,,KqnOTkʄsQ$fz~*n.p{=?){sއHQP =!PFAO+FmHU=Q2cWM/ܢ#H+Bh)s]BAyoJU*' R]Rlਜ}kb$4(ulshBiq-u4a^ 𬐄-_I)„FaCO9.e/{~yVδyGTrÿ?҃ū[Ջ{$$cNx4,4XTI!*[V8'M$u)+^ژ}] IXhǒsMŦƎDiB^PH J2ӛ%\(ypVž0IlYtŦeVׁ[o OO C ^1!^^-f (!8mX5|M¥NGnW}J=!2c,%%![%NtJ>}Blz!ȳ^ƂHkgja0X:mOTdй$K< i3]`<%+Qh!]) f#ZOh%[uQam(Oļr~zCM~qa,D[JIsRΜoҶ ό4ddcwSJZ)@#Z`)~i#o䍜6s_eIρ)jdUiy1VJo?pS{_xhz[+=PiSp`hl _:ՎNR.\}k/9n/WRg7o$Fx rUmC9ZK$;\XPג/WfYCmdU;Ē$JOFqYuʎ[*Z{*f.>sOq*{j?:v2..!!^┑֊bTm[ќ*hh%C K\[R&QplV-o%͙ @7]*]ʹcn^PYXoj5d\D-TygpDyL[(Zdg#O֨ęE^! q\}1*sNW䅐GP $eY>F&4GbL.myvˋ/F},F@[P4H`0׽R2^r.F T϶ b-:r:wup`=ڔ.WԀ{u)O/8$ Kˆ3hr889NۑZi3ǁcpmR}ּx6oW@p;+)d'Q2Z$|,0>~+Ďy>-#ΫnW[:؉1ҟHUT$|BVII8wkm*:(dzfU߿~5ۣ-3ܺHk䤩>|}?ziOqW_ķ\{ { zBJA)OuWT9iKi%(# BUm}9g軡9{#qޗ:K yWƚ|Ďi{іY[g@an! 2`EXsUcQIfMg.3Jj7#9^CrqlRsV׉\P@K/$+iGΰmC~=yz4|~B48^ڍERV\O|֓a1dhm!n+y>V_%ɴȆ, c5[ 'KEšNKei+: =s,z̧ )EUlj>|Z8A?+u>Rʥ{W 7a$sڄ;̖2ۻhb.M9n@p.F%ȔېcIG-O&rp^W ڣ [y8?Jcޏvt~cx* u@+]`[M=яBOӏD|GʃyrO>^wץ'D-I>2Χ"] JN(]д:BԭG/l04ܐkz[vj*֗ 61K#Tgd/6% r~贅Rx4&Iqe@Eyu+Êֶ騺%dKc5ӌ!$vTmNsr\[O:ڒ V~fX)NF>t&K qS(GinQunVQMkexi[I~&[ cQKJ ]LԌgjQjNO+ןd> +0h\RQg^ J$9yRUgR2BڥJ]b35*Pv)MVs5*QDEJE"y5*T