JFIFFPhotoshop 3.08BIM*@Untangling chromosomal and hormonal effects to make sex-specific720260830PNathaniel BowmanUAuthorgUntangling chromosomal and hormonal effects to make sex-specific endothelial OCT4 clinically actionable Science@https://scienmag.com/untangling-chromosomal-and-hormonal-effects© 2026 Sciencehttps://scienmag.com/]The vascular biology community has just been handed both a discovery and a warning in a single package. In a Letter published on 12 February 2026 in the journal Angiogenesis, M. Vijayasimha of Chandigarh University, M. Srikanth of the Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences in Rohtak, and Rajeev Kumar Jha […]ScienceCanCancerCancer6chromosomal versus hormonal influences on angiogenesis7clinical implications of OCT4 in blood vessel formation$endothelial response to sex hormones)methodology flaws in angiogenesis studiesOCT4 in vascular biology,reproductive biology and blood vessel growth.sex chromosome effects on angiogenic responses-sex differences in ischemic disease treatment&sex-specific endothelial cell function+standardization of angiogenesis measurement-translational challenges in vascular research.vascular regeneration and sex-specific factorsC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"<!1AQa"q2B#3R$4b%CS0!1A2"3Qaq#4b ?~,f}S XR@ZGL<T6G)ܞ6*~&ֶ sƁRS>i!25K>`Kf1 SrqO7R<(?W/vg lUOZen q-JWq▓V Aq&3쭽i u%ufwp'ʀ Hqi #M(@^͓u&x'v[Q`u;#/CȺpWn&r%**/}S! supO[%RPqz [9f7GꐪebmlP|I;NIOIpNu|5$R@=߅b߮o~\R?Vxy,['*?WC)(㎭C[a) s┳2к\?#:mŠRRԥNMJ "e(/o : ٝKPʘ' ABmtUsPSO.r?x؆)a +N 9۝k>('wZmw6sjWU¼Pס=0GO֘Wޯ*}J@4IM+=(4r[{`A)pE$pa*MKLRJ7+ah7GieyG\_Un"4%aS[t+el-UpO{Unopmˠ!G[+mP}!m9}t7.)G`N6<Wyo״74 VR}T|kS N*L!wgCx%]V|AMHڏ &\P1B[9  +h8+ZBVIPX4Jɒ5c"seAQ):JEkI[uѭ=JJzmo_{ՊQ8j6:'`q#cn-aVahr7Ѹ$Ƶ9 ȌV{t'֑x9-*Ԅ'aG,ox%ޔbjҶ]Sb0WsBߥw O//uJaU*C}޷EFH)wGbXJZ^}Y#dAA˜A.Ljӄ7oP$5]m\~`TpsOX]F2hF6:$O󡶨,͞haԆ Gle-/9iLl(5$UòW÷mHNKXjY!qzcVBޅ[kj p3˸My2bO1CPvTt.1,ķ,>˫B Ztg,e4@][`lX8Tܢ*CE!K '13隵}rJǦ:0qz?:/SSo9SfDpK^.q:q^ ;w"H2vl8bg:AW,?Pւ'.Luȕ '%XJA!==Եr3=6DФ}P 5o<=݂6+_{ai o?ZXx2QӦ 2d.D7==}}Sf4e<ġc p|Qc"3ӏU5T(e#\KW]Al<qn,K%D5>dG4fw&&VeJ?yIؑ;FED0Y&aZW!00F8`zlkKIoEn(/ JaWKM4mzWR$:ֺ;ElƱwO_R}"V֋\Q3_!<ue~pHYrLƣ\VH_0vF(4JIQd$Z50cM8m!KY蔌Qdh2Ω'VmvUdyh8>׋#)>M%vy-.1pQ+:Hwxz2.#$h' In +H*QzsKxH^l Pr*[J=NJvrMJi XH|N &Ht k?C􌝘r+G8:ʻUJ W%ڭœ*b*fRq,&[lҙ9Zh$wkEm@"iR 8}6ޝlwn9?%D|2Fp?*-׫30RJRZf%\YQs5}"eݥ_}} m}9KUsqr-3L$a޸XeR\%ee`/:=Z%2Uq 8wǥ]8r~[ bMtY23YZnu1pOܸ}A$CV[e\VRÁ +tZ %AI$)'*'sIs_壪)7EiۦEśdLAuŐ02NMb5#{>l;w$[SȖMr pOAMjmZfp,ҐdLAkr6.NBӹ#Un9cK0i«ûPҰ3=B)cI˗55W9MFgvIZjWA3,#L~GvoN )&ߝ['k -%l9I'fRGmߴg%.) ;-C+tn~uN^ۿX!%$5Nà@f]0;*9> R:~zGOD[$;GDzUT A!zQcR$cT94 F >Ԑq5HUu!(|L(B]V ;Iuv-eFؓZ48[o͗