JFIFPhotoshop 3.08BIMv@Shikonin compound triggers prostate cancer cell death through he720260903PNathaniel BowmanUAuthorcShikonin compound triggers prostate cancer cell death through heme oxygenase-1 and ERK/p38 pathways Science@https://scienmag.com/shikonin-compound-triggers-prostate-cancer-© 2026 Sciencehttps://scienmag.com/Prostate cancer remains one of the most frequently diagnosed malignancies in men worldwide, and while localised disease can often be managed successfully with surgery or radiotherapy, advanced and metastatic prostate cancer continues to pose a formidable clinical challenge. Standard options for advanced disease—chemotherapy, salvage radiotherapy, and androgen deprivation therapy—can extend survival, but resistance eventually develops […]ScienceBioBiologyBiology,apoptosis induction in prostate cancer cells$ERK/p38 signaling in prostate cancer"heme oxygenase-1 pathway in cancer2molecular mechanisms of prostate cancer cell death?natural compounds with potential for metastatic prostate cancer*natural plant compounds for cancer therapy plant-derived anti-cancer agentsprostate cancer treatment&resistance in advanced prostate cancer*role of heme oxygenase-1 in cancer therapy(shikonin derivatives anticancer activity.signaling pathways targeted in prostate cancerC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"<!1"Aa2Qq#B$3C%4Rbcr5!1AQ"aq#2345rBCb ?Ȯzщ+}^Y; fisaZP.Rc =ծrZ9rTsWK9ǥ E´-U+dO83 @S&%e-ʑUN/K|*uyl!Dl+ҞEӊQIJd:rWak^+U@APN"> 7hs>9Hs^S )+*aL*꒼tJśxYl4HmP#4vM$QȧX+09sq9*y*iDNh2)jj|7mԷK+ۙV:ih:Ɛ۟ AYxYu\b:n<JԚ@{f5ʑgǢpH#ƥYɵ1Gc^#9)8f o&ELvw$QbM  rF޸y;"2ph=ȩ7`BƎ;jSEmJn)R8.HH*AH)WJw_U_VE4zux>"*iڔ aWfb7M'+E!Fh2Ij"p}*+:w֠={T;KWGyw9ȋڢ FT&Óze O4Dґm6Tt[o_SA5׳)j/mZXי`ګ6)vL3. zx4ԏ *8{`-f66`D1-K4̼FV=#:#L^y%sNa{;eI;eAlxp's_zb^EIax/P!rhA,9 cKn{y8akKrZ,v!(O=+ m!c62 UN ;~Vev=&uɎET+{[*!#.ctlR`Z Z3Y^˜+!9Y\ZẆ*óou)?+=C`:C3*xGڋy!Ohdu<جi&~ ֤:TH|FJm=ʹ$AU:QD;nSbjWqBԃ.toURsAӬI{o9->ZzWҕ*qǭA/yF11em[&ܐ3cPEttL3{/ Z]{SKh,o~HVgThрAA,f@3X] `uQe 7ܞ+V "v8iο{/!3#.28,Ym-P6Po|? 龮no2ܴW1HsLd18GMz9Eef,ȰJ.\%MʠpCG M>9myYc,'sYj=St(LjO۷ڏ{-ѣuE`yo=akSӑbI 2b?B>^4 FVhwTh^K<EhZ7B*(jhVsJC*k+ƫWQ=jv@,/O֮9W=S@Q[JC`e:KWLڀ^<39ڻ y63`&`0$bٙ,崒+_^)a֬bUuר5`s юx!a$sZU58ysN~P\\ I`y#BzW,`k)Yۈ`xlFA}6: iӴ.n{]s.䘏U=;˾0tP6aowW=;t{G ǘGUo,dJYH`qrp==JvdTfTvB{n[ thb3?$џ+ |;cձGEHmű8)n\} YD4r@g H#W'tSAJdpNhf,w3NDX`ڬU?Li\1os\Y;A ~,q6 /}OE&ch~2W>=Z=>jҞx!BX UJɾaPB lnr+ ds%Hӓui{{8(>ƃOKֳ0 p ZXr (24MJ;F@0s3_? "vwFډIj#q@jnovCN~)xP^)%,ķ}u;kX4I!1ʳ;ȸ G`ymo5Z{G>uL39<nCi4ώq1 ?Z?x퐏4hⅹ@hm}SKU?˛Cm6S&,ejo89?UG:x, ;.uG?άK2]Gy ۼe]w㬗 )We9NpfĿ[{©#R5jp>Ѯź+>مZ͊ƌ#n8m{F]ևklH_]Ofi|YZNRP.9Y:-88 "^atrpM)Ԝ3mDE/$~Tag]!*[;n?* 9zTó?'Ip]HԳADSET(n$Д@"Hd}ޓ˿8 3YR̓V\vTt]V-+Cj^5gwj4gMV#wVE1I URojHdmUy(V4ByY:r A?jY!&}QCtwmP/:bLlh$ho(`sm[Qa'q9z~c#wcO$=H`ȍ$z>z1jgST6_LTұA\b/'R2jTWFA5 {9W^ 5tD"uMͫm-Ay3^ʻXaQ5&l*TJtl}j\|o `tZM^EX}C:.AXcL7jkK'Ȕ6z!IT[!le1c9%} o ?J]N W}󷍶\*-ӍFY,҂[9ZXJS4赝]1c,7Wr0NM=a;>;s,rAZcXٝd2{c2iyBFŤ?(d =IM.qLZ컅L';((٥+-cAi{Kv9:f":& _S\[ ˀPoVcp*٫k.N9Rl9Ξ`-@;v7)r:` ܠ?9iٟsLM4OX4^R)TիAqGjzbʊT}#衂}Vzu>c֬|YqJOG@u0>ګC"ԩS _W?NZN<y|ҥHܳ ]RL[?lz-<ԯ(,XEC*; 3}VۤZOEuҔ;Po!}Rܹ?z xǭSJj)-~=*Tٻ'M\ҥJ