JFIFPhotoshop 3.08BIM?Gut microbial metabolite imidazole propionate drives sclerosing720260910P Morgan MorrowUAuthoraGut microbial metabolite imidazole propionate drives sclerosing cholangitis through p38 signaling Science@https://scienmag.com/gut-microbial-metabolite-imidazole-propiona© 2026 Sciencehttps://scienmag.com/In a discovery that reshapes how scientists understand one of medicine’s most stubborn liver diseases, researchers have identified a molecule produced by gut bacteria as a central driver of primary sclerosing cholangitis, a chronic inflammatory condition of the bile ducts that can progress to cirrhosis and liver failure. The findings, published in Nature Metabolism, reveal […]ScienceMedMedicineMedicinebile duct inflammation-Gut microbial metabolite imidazole propionategut-liver axis$inflammation-driven bile duct damage'intestinal microbiota and liver disease+microbial metabolite-driven liver pathologyµbial metabolites in liver disease)novel therapeutic targets for cholangitisp38 signaling pathwayprimary sclerosing cholangitisPSC pathogenesis&role of gut bacteria in liver fibrosisC    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$" B  !1AQ"aq2#B3Rr$%47Cbt/!1AQa2q"3B ?vG)BYF>k.=xVS>YYr$.~«m6OAp$ .;NO(.f3`q߷Ui:U[Ēlrb*'qӹ݁g֓Z4Xij` @CGn|]HWn93S@ 0E,s3ɠ#:TMOvndaf݆PF3%T~}:;<~n|1~/իCov3ym0 )tm#MR:vF z23@]N`u7UW  88#z7ƎME(I#xǟ3ny${iF`]YU:YHf.IÅ@ EpsޟO З;eaM]_ŢM aK2c+IcΥ+q&dE&dg Zm"E"F>t~oxŌ3/[~SUE (*?S{."I9s}$QipϞ/TUtI\.?(l!ܛ&4W]gb+Xa9ݞ9*B F+f/ \旪 (o}(U[t>tf$ 6w \Z ?!P2;stͦ["[DHVQDIk]}hIful-Hs3SVe_kZ Oio2 9,pvӹ|.Эt\j%~b/*rI8횶XPɧي[tIedFF#) ?WPH~KMRYAY!ἌŃl}Hi :noԑA &i1+1ˎ~gM-5kos+o_5BJ%Eer`.OSѵ{gRJ 0 n'Κ3&}A9FqlNJ8*i3lqT]ZB(U0-+Z֢yl.dC/=ڭ;M:aETP`ԧIgBHUNH98Fh m*8m.IƓ]\78}="מ8J!/(՜2psV( ~c7w|Ԭ޺H 0A#H@Vu}3Tem.9T{݁ʪ=Q[BKĿ]6cngpEUOe)>1,^ULHW8<'%Mj$k*/.|#c-R58qޫL]Z|dE% 9䑌voBKW-m E 0Iy 7{ԟO*͞ep_Z!|sp|\ݡdI/p|E1~A|IF1]HC bW&h(#Q@AR7ep5Lm-W( ((Cm,u[M)U/.O1ɉ1˷l i H{ P^[OuKQ$ ԺNq-s΢KGr DO^of #vJDԝ7| YCT=%HZ9săkяբzsN/ꝶIh>kɶuRmi X} $VxEhUת8 d+kqĊO}zaW:- Gatϟ![b:E[;DS>|w\zoqa#&kդWeg'͜L $=^7pԽi2Qm4:b4 _}*k귬r x5/aзh\Pb;@dzxzOk2xGvBiَi\|Y:+O1w4*nm"N$N|NiV@m4ԁ!h<2J <+m$hkD+$y# 8>1Z')5~K_.< ki~$} CCtMEۼSd#$+z5Xגʷb`Ì帜:CݭV==%TvXcJx@ޭ,|V2gZo|#MkwLVX淕9H?TZk |نyԷ% uooshLG΢'mI"{;#g0v:d蔽KJOmokN?E|bVŦFoRiKť&7A^+ygEs:h2hھ+֊2l1EW *Zf&+,,Gժgfu; rncJғC5mm5m$I7׽ؓ5|$uoZijs0Kxeo\w{KmވJOCslM+FW`R]l%Yʑe$ (r 4mw@xp[9 < |d3PUQY] !5±w}*$:^_>AO 򮑡.uScHX$!݃qwpx.YzTU*!-uG3 ,vesڝZ6(FFG- GҺuװޒ;ynt;dzOH'=U`~6ø"<8Wc2xN;v/o]x)v >[Qƻr Yߪu+"m| |4~GLN 5مx_]gH1ɮ5=cӺwp=/g}UrqyTGymσY?K4w=?U_ϡ^z]X8හEϧKKı)8 FwZ_s|ɢG'+3Q__:J5y{]>w;{Os6q:OrL#ߴϯ.}=i]uLm#;>u@G0 @FX֗ <1&p@~BQ@PhZ?}kΞӺyM܅sd=O^mc9\{[gOۃZ⛄hE(cJɐ0A5(LN@# w(/&dL\.H㏮?ZB;XJoK6}FIDĬt󽈚dLcқ_*9PH>j8)ť,勫(sH]^kI6+0SGu}6 5UVߝy>}"NOa@TM'b0I?S@QBop=hQ\EyPMq|qjuU]I~B?;H%|!;Oi"NI4 tQEETOAխe{:;pI~G&JAHEk>Ln*0+4QC ( }nOvgњ(x(=IyE}Hg 9Qs1(=Pc9QE`s((aX z (3…Q(< (