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The development of effective therapies for diseases affecting longevity and quality of life has significantly advanced with the use of sophisticated animal models. One of the most notable advancements in this field is the severely immunodeficient NOG mouse, first introduced in 2006. The NOG mouse lacks functional T cells, B cells, and NK cells, exhibits dysfunctional macrophages and dendritic cells, and has impaired cytokine production and reduced complement activity. These features enable the engraftment of human immune cells (including CD34+ hematopoietic stem cells and peripheral blood mononuclear cells (PBMCs), making it a highly valuable platform for studying immunology, oncology, autoimmune diseases, inflammation, infectious diseases, and regenerative medicine.
Refining Disease Modeling and Reducing Study Complexity
The NOG platform provides a robust model for studying human disease mechanisms, disease progression, and therapeutic response. By closely replicating human immune system interactions, these models facilitate a more precise understanding of disease biology, ultimately reducing the number of animals required per study. This aligns with the 3Rs principle (Replacement, Reduction, and Refinement) in animal research by enhancing study efficiency while maintaining scientific rigor.
Further genetic refinements to the NOG platform enable more tailored disease modeling. The NOG portfolio offers several variants of human cytokine transgenics to tailor to researcher needs. These include human transgenes of several interleukins, myeloid compartment, and even an Fc gamma receptor knockout portfolio for antibody drug development. Taconic Biosciences offers custom model generation capabilities that allow for additional precise genomic modifications, depending on individual needs. These innovations provide researchers with highly controlled experimental conditions to investigate the complex interplay between human immune components and disease pathology.
Streamlined Access and Cost-Effective Solutions
Taconic Biosciences prioritizes accessibility and efficiency in preclinical research. Unlike other providers, Taconic does not charge access fees for the use of NOG mice, which can otherwise range between $15,000 and $30,000. Additionally, all mice are produced domestically, reducing logistical costs and ensuring a reliable supply chain.
Solutions for Every Study
A dedicated team of experts is on hand to discuss specific research needs from study conception to delivery and beyond. Rather than offering a one-size-fits-all approach, Taconic Biosciences offers a spectrum of solutions tailored to scientists’ unique project needs. If additional gene modifications of our NOG lines is of interest, our Custom Model Generation Solutions team can assess the feasibility of your needs. With this broad range of targeted solutions, finding the right mouse at the right time saves research resources and speeds up timelines.
Taconic Biosciences is committed to advancing drug discovery by providing researchers with access to cutting-edge genetically engineered mouse models. Through rigorous genetic, health, and quality standards, Taconic ensures that scientists have the tools necessary to drive breakthrough discoveries in immunology, oncology, and beyond.
For more information, visit taconic.com/gen.
