Brain–computer interfaces (BCIs) have the potential to restore communication for people who have lost the ability to speak owing to a neurological disease or injury. BCIs have been used to translate the neural correlates of attempted speech into text1,2,3. However, text communication fails to capture the nuances of human speech, such as prosody and immediately hearing one’s own voice. Here we demonstrate a brain-to-voice neuroprosthesis that instantaneously synthesizes voice with closed-loop audio feedback by decoding neural activity from 256 microelectrodes implanted into the ventral precentral gyrus of a man with amyotrophic lateral sclerosis and severe dysarthria. We overcame the challenge of lacking ground-truth speech for training the neural decoder and were able to accurately synthesize his voice. Along with phonemic content, we were also able to decode paralinguistic features from intracortical activity, enabling the participant to modulate his BCI-synthesized voice in real time to change intonation and sing short melodies. These results demonstrate the feasibility of enabling people with paralysis to speak intelligibly and expressively through a BCI.
Wairagkar, M., Card, N.S., Singer-Clark, T. et al. An instantaneous voice-synthesis neuroprosthesis.
Nature (2025).
.adsslot_r5d8WYNjnI{ width:728px !important; height:90px !important; }
@media (max-width:1199px) { .adsslot_r5d8WYNjnI{ width:468px !important; height:60px !important; } }
@media (max-width:767px) { .adsslot_r5d8WYNjnI{ width:320px !important; height:50px !important; } }
ADVERTISEMENT
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:
Subject of Research:
Article Title:
Article References:
Wairagkar, M., Card, N.S., Singer-Clark, T. et al. An instantaneous voice-synthesis neuroprosthesis.
Nature (2025). https://doi.org/10.1038/s41586-025-09127-3
Image Credits: AI Generated
DOI:
Keywords
Tags: amyotrophic lateral sclerosis innovationsassistive technology for speech restorationbrain-computer interfacesclosed-loop audio feedback technologydecoding neural activity for speechenhancing expressiveness in synthetic voicesintracortical activity decodingneuroscience advancements in communicationparalinguistic features in speechreal-time voice modulationrestoring communication for paralysisvoice synthesis neuroprosthesis
