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Tangential Flow Filtration (TFF) is a crucial technology for manufacturing monoclonal antibodies (mAb), adeno-associated viruses (AAVs), and other biopharmaceuticals. However, challenges with separation efficiency and performance issues can lead to inconsistent outcomes from biomanufacturing workflows that waste time and resources. Newer TFF designs address these issues, helping modern manufacturers work more efficiently, mitigate the risks of product loss, and obtain consistent results from multiple runs.
In this GEN webinar, Mark Perreault will share case studies showcasing TFF design innovations for handling mAb and AAV production workflows. He will introduce a novel flat sheet design that eliminates the need for traditional cassette holders and ensures uniform flow distribution across the membrane surface, enabling consistent performance, and enhanced product recovery. He will also demonstrate the design’s multi-use processing capabilities. Attendees will learn how this design reduces process set-up time by up to 80% while minimizing torquing and product loss. Key takeaways from the webinar include:
- How a holder-less design improves process reliability by eliminating installation issues and reducing operational complexity.
- How the design offers seamless scalability, as the device maintains consistent channel path lengths and pressure drop profiles across cassette formats.
- How uniform flow distribution enhances product yield and reduces variability in performance.
- Results that show that separation efficiency, flux rates, and fouling resistance are equivalent to traditional cassettes.
- Practical applications, including mAb and AAV process applications, and demonstrating the device’s suitability for multi-use bioprocessing workflows.
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.
Senior Director of Research & Development
Repligen
